Abstract
Urinary incontinence (UI) is one of the most common conditions that cause a significant psychosocial and hygienic problem in an aging female population. In this article we focus on the sphincteric type of stress UI in women, review the anatomy of the urethral sphincter and its support mechanism, and discuss methods of the evaluation of urethral function. Stress UI is the functional consequence of an anatomical abnormality, urethral hypermobility (UH) and intrinsic sphincter deficiency (ISD). Imaging plays an adjunct role to urodynamics in the assessment of women with UI. MR imaging due to its superior soft tissue contrast resolution contributes many findings that are predictive of UH, such as abnormal descent of the bladder neck, disruption of periurethral ligaments and vaginal attachments, and defects within the levator ani muscle. In ISD, MR imaging may show foreshortening or thinning of the sphincter muscle and bladder neck insufficiency manifested by funneling. MR imaging is ideal to evaluate the anatomy of the bladder neck and urethra; functional implications correlate well with functional studies and make MR imaging central to understanding the causes of stress UI and its thorough evaluation.
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Urinary incontinence (UI) is the involuntary loss of urine. In a female population, UI is one of the most common conditions that cause a significant psychosocial and hygienic problem [1]. UI can be caused by urinary bladder abnormalities, such as detrussor overactivity and low bladder compliance, and urethral sphincter abnormalities. The primary types of UI include: (a) stress incontinence, urine loss during physical activity that increases abdominal pressure (e.g., coughing, sneezing, laughing); (b) urge incontinence, urine loss with urgent need to void and involuntary bladder contraction (detrusor instability); (c) mixed—both stress and urge incontinence, (d) overflow incontinence, with constant dribbling of urine and bladder incompletely emptying. Of the several types of UI, stress UI is the most common in women. Some of the causes include loss of urethral compression and support after previous pelvic surgery, childbirth, or trauma, reduced sphincteric function in lumbosacral neurologic conditions, and because of aging with hypoestrogenic state. Urge incontinence is most common in the elderly and may be a sign of bladder infection. Overflow incontinence is more common in people with neurogenic disorders and older men with bladder outlet obstruction because of benign prostatic hypertrophy. In this article we focus on the sphincteric type of stress UI in women. Sphincteric incontinence is related to urethral hypermobility (UH) and intrinsic sphincter deficiency (ISD) [2]. The basic abnormality in UH is a weakness of pelvic floor support that results in a rotational descent of the vesical neck and urethra during increases in abdominal pressure. When the poorly supported posterior urethra continues its excursion away from the better supported anterior urethra, the urethrovesical junction opens concomitantly with its descent and UI ensues. In ISD, there is malfunction of the urethral sphincter, rather than pelvic floor defect, which leads to low urethra closure pressures. As a result of weakening of the sphincter, the vesical neck opens at rest or strain leading to UI symptoms [3]. The normal female urethra remains closed no matter what degree of stress (increase in intraabdominal pressure) or rotational descent is present.
Traditionally, studying the urethra and its supporting structures has been possible with procedures that indirectly evaluate urethral anatomy and function. Cystourethroscopy assesses the urethral coaptation, which is the ability to close the urethral lumen, and the status of the mucosa. Neural control can be assessed with bladder and urethral sphincter electromyography (EMG). Videourodynamics combining urethral pressure measurements and urethrocystography have been used to assess the process of bladder filling and compliance, micturition, and urethral closure. Direct visualization of the urethral wall can be performed with ultrasound, using the transabdominal, translabial, transperineal, endovaginal, transrectal, or intraurethral approach [4–9], and with MR imaging. With its excellent soft tissue contrast and multiplanar acquisition, MR imaging enhances the ability to visualize the female urethra and periurethral tissues relevant to UI. Standard evaluation of the female urethra with MR involves the use of pelvic surface coils; however, endocavitary MR coils, endovaginal [10], endorectal [11], and intraurethral [12] have subsequently allowed MR imaging of the urethra with increased spatial resolution and high signal-to-noise ratio (SNR). With the increasing anatomical detail of urethral anatomy that can be visualized on MR imaging, our understanding of the morphological changes related to stress UI should improve, and it is expected that new methods for diagnosis and staging of urethral dysfunction will be devised.
In this article we review the anatomy of the female urethral sphincter and periurethral attachments that promote continence, and discuss methods of the evaluation of urethral morphology and function. We also illustrate the MR imaging findings in stress urinary incontinence related to UH and ISD in women.
Anatomy of urethra
The female urethra is about 3.5–4.5 cm long, with at least 2/3 of the proximal urethra positioned above the levator ani (pelvic diaphragm) level. The proximal 1/3 of the urethra is lined with transitional cell epithelium. The mid and distal urethra is lined with pseudo-stratified columnar epithelium. Infoldings of urothelial tissue with rich submucosal vascular plexuses, mucosal secretions, and urethral smooth muscle contribute to passive urethral closure (urethral coaptation and mucosal seal). The urethral sphincter muscle comprises involuntary inner smooth muscle, and the voluntary external sphincter (rhabdosphincter) comprises striated muscle. In the histologic study of paraurethral anatomy, DeLancey defined four segments along the urethral length between the internal urethral meatus and the external meatus [13]. MR imaging with its high soft tissue contrast resolution allows visualization of the urethra and supporting structures with great detail, and these four distinct portions of the urethra can be seen on imaging. The proximal 20% of the urethra is the intramural urethra which traverses the urinary bladder wall. As the urethra passes through the wall of the bladder, the muscle fibers (low intensity on T2-weighted imaging) of the detrusor extend as far as 20% of the urethral length below the internal urethral meatus (Fig. 1). The mid-40% of the urethra shows the smooth and striated muscles of the urethral sphincter. The striated urethral sphincter is divided into three components: (a) the urethral sphincter surrounding circularly the proximal and midurethra where the urethra is separable from the adjacent vaginal wall, (b) the urethrovaginal sphincter with fibers surrounding both the urethra and the vagina (Fig. 1), and (c) the compressor urethrae with fibers running from the ischiopubic rami and also originating from the perineal membrane itself to the anterior urethra, where they meet fibers from the opposite side forming a broad arcing muscle [14]. In the axial plane, T2-weighted images of the midurethra show a multilayered target appearance (Fig. 2). The inner smooth muscle layer (longitudinal and circumferential) [15] in a loose connective tissue matrix shows high signal intensity. The smooth muscle layer is thickest at the midurethral level and on the ventral side of the urethra. The outer layer of low-intensity tissue encircling the smooth muscle represents the striated urogenital sphincter muscle (rhabdosphincter) within a dense connective tissue layer (Fig. 2). The striated muscle is thicker on the ventral and lateral side of the urethra, and thinner on the dorsal side. On the transverse sections, the target-like appearance of the midurethra differs slightly at the upper, mid, and lower midurethra segments. The thickness of the smooth and striated muscle layers differs along the midurethral length, with the upper and midsegments thicker than the lower segment [12]. Urethral sphincteric function depends on the integrity of the mucosa, submucosa, and smooth urethra muscle layers as well as the striated urethral sphincter responsible for compressing the urethra directly via its circular fibers (urethral and urethrovaginal portions) and for pulling it deeper into the anterior wall of the vagina through its arcing fibers of the compressor urethrae portion. In combination with the action of the pelvic diaphragm that elevates the bladder, the urethral sphincter assists in the elongation of the urethra. The urethral elongation has been found important in providing continence [14]. About 20% of the distal urethral length is embedded in the urogenital diaphragm supported by the compressor urethrae muscle and the urethrovaginal sphincter muscle [13]. The most distal 20% of the urethra below the pelvic floor level where the urethra passes between the vestibular bulbs and the bulbocavernosus muscle, is composed only of the fibrous tissue without any skeletal and smooth muscle component (Fig. 1).
Both pelvic muscles and fasciae determine the support of the urethra. The fascial attachments of the urethra connect the periurethral tissues and anterior vaginal wall to the arcus tendineus fascia pelvis and have been called the paravaginal fascial attachments.
Vesicopelvic and urethropelvic fascia provide anterior and lateral support to the bladder neck and urethra by means of attachment to the pubic bone and arcus tendineus fascia pelvis. The endopelvic fascia has condensations forming ligaments of the supporting system of the urethra. MR imaging allows visualization of those ligaments [16–18]. Three groups of ligaments supporting the urethra have been described. The anterior support ligaments include the periurethral ligament (PEL), a thin hypointense structure originating from the medial aspects of the puborectalis muscle and coursing ventrally to the urethra (Fig. 1), and the anterior pubourethral ligaments, paired ligaments extending from the pubis to the anterior aspect of PEL, best seen on axial or sagittal MR images (Fig. 1). The lateral ligamentous support is provided by the paraurethral ligaments which are slightly oblique hypointense thin structures connecting the lateral wall of urethra to the periurethral ligament [18]. The posterior support of the urethra is provided mainly by the vagina. There are fibers that connect the vagina to the puborectalis portion of the levator ani muscle (Fig. 1), the vaginolevator attachment. The vaginolevator attachment is formed by the fibrous tissue and smooth muscle of the vaginal wall which is inserted into the body of the puborectalis muscle. The urethra is inseparable from the anterior vaginal wall for the distal half of its course. Along the proximal half of the urethra, the dorsal support is also provided by a ligamentous hypointense structure traversing between the vagina and posterior wall of the proximal urethra and connecting to the levator ani at vaginolevator attachment point. This posterior periurethral ligament provides an additional hammock structure for the posterior support of urethra and is best seen on high-resolution axial endovaginal MR images (Fig. 1). Increases in abdominal pressure compress the urethra against the vaginal wall, which acts as a supporting hammock [19]. Lateral detachment of the paravaginal fascial connections from the pelvic wall is associated with stress incontinence and anterior prolapse (cystocele resulting from the abnormal bladder descent) when the firm vaginal support is lost and the compressive force from the vagina on the urethra diminishes.
Functional evaluation of the urethra—urodynamics
Urodynamic tests are the most important functional tests in urinary dysfunction. The purpose of urodynamic assessment is to determine the etiology of incontinence and to evaluate detrusor function. The parameters that are measured during an urodynamic procedure include: pressures (in the bladder and urethra), urine flow, and electromyography (EMG) of the pelvic floor muscle. The cystometrogram is performed to evaluate the compliance and stability of the detrusor muscle. Compliance is simply the elastic property of the detrusor muscles. An evaluation of compliance is an evaluation of the ability of the bladder to “stretch” to “normal” capacity while maintaining low pressures. Stability is evaluated by observing the detrusor while filling the bladder to normal capacity. The evaluation determines the presence or absence of detrusor instability. Vesical pressure is the pressure that is measured with a catheter placed inside the bladder. The pressure is a combination of the pressure being exerted on the bladder by the abdominal contents, the weight or pressure of any urine in the bladder and the force that the detrusor muscle is exerting on that fluid. Abdominal pressure is measured by placing a catheter either in the rectum or the vagina. Abdominal pressure is significant because the bladder is contained by the floor of the abdominal cavity, and it is important to isolate pressures occurring in the bladder itself. For the patient to remain dry, the pressure in the urethra should be equal or greater than the vesical pressure, during bladder filling. The maximum urethral closure pressure for women under the age of 50 is on average 70 cm H2O, whereas for women aged over 80 it is 24 cm H2O [20]. When the bladder and urethra are in their proper anatomical location above the pelvic floor level, any pressure increases in the abdominal cavity, from strain or any other cause, will be reflected in both the vesical and urethral pressures, keeping the pressures in the urethra greater than the pressure in the bladder. With aging, chronically increased intraabdominal pressures with coughing, or after childbearing, pelvic surgeries, the female pelvic floor defects can cause the bladder neck and urethra to fall below the pelvic floor level. Increase in abdominal pressures during a Valsalva will lead to pressures in the bladder being higher than in the urethra. This results in urine leakage with increasing abdominal pressures or stress incontinence [21]. Video-urodynamics by simultaneous registration of pressure in the bladder and rectum, and visualizing on fluoroscopy the bladder cycle through the filling and emptying phases provide additional information by generating radiographs representative of functional states during voiding that can be directly correlated with pressure changes.
Cystourethrography and ultrasound
Voiding cystourethrography (Fig. 3) is used to evaluate the anatomical integrity and relationships of the bladder and urethra. It allows the evaluation of the bladder neck and urethral mobility during voiding, and detects cystoceles (bladder prolapse) related to support defects. The exam involves catheterization of the bladder and retrograde filling of the bladder with contrast, and subsequent monitoring and documentation of bladder descent and urethra mobility during voiding.
Ultrasonography is inexpensive, easy to apply and non-invasive technique free of radiation exposure that has been successfully utilized in the evaluation of the urethrovesical junction in stress urinary incontinence. Ultrasound allows direct visualization of the urethra (Fig. 4) and can be used to assess urethral muscle thickness [22] and volume, bladder neck mobility and competence at rest and during strain [23, 24]. Ultrasound may help in documenting bladder prolapse, urethral hypermobility and bladder neck insufficiency—funneling [23]. High-resolution intraurethral ultrasound was investigated [22] and provided excellent cross-sectional images that allow for real-time visualization of the urethral rhabdosphincter. Urethra support mechanism, however, can only be evaluated indirectly with ultrasound based on the urethral motion, as the ligaments supporting the urethra cannot be visualized with ultrasound.
MR imaging of urethra
MR imaging with its high soft tissue contrast resolution allows the visualization of the urethra and its supporting structures with great detail, and also permits the evaluation of urethral mobility and bladder neck competence during strain and Valsalva. The position and mobility of the anterior vagina, bladder, and urethra are important to urinary continence and anterior prolapse. At rest the urethral axis is vertical and in continent women positioned above the level of pelvic diaphragm. With increasing abdominal pressure and laxity of the pelvic floor and urethral attachments, there is rotational descent of the urethra (Fig. 5). When the urethral axis rotates over 30°, it is defined as UH. Urethral mobility is tested clinically with the Q-tip test [25]. The Q-tip test is performed by inserting a lubricated sterile cotton-tipped applicator into the bladder to the level of vesical neck; the resting angle is recorded. The patient is asked to strain, and the degree of rotation is assessed. UH is defined clinically as a resting or straining angle of greater than 30° from the horizontal, in a patient in lithotomy position. MR imaging is able to demonstrate not only the hypermobility of urethra, but also other associated findings. UH of the urethra is often accompanied by moderate to severe bladder descent with anterior bulging of the vagina (anterior prolapse—cystocele). In severe cases, the anterior vagina can even protrude through the introitus.
On MR imaging, urethral and bladder descent are assessed in reference to the level of the pelvic floor which can be defined by a pubococcygeal line (PCL) extending from the most inferior portion of the symphysis pubis to the sacrococcygeal joint [26, 27]. The pubococcygeal line can also be drawn from the inferior pubic symphysis to the last coccygeal joint or the junction of the first and second coccygeal segments on a midsagittal image [28, 29] (Fig. 6). Components of the pelvic floor support, such as the pubo-coccygeus muscle attach along this line. The advantage of this reference line is that it can be reproduced easily in all patients, and it is independent of the pelvic tilt. The degree of descent of the pelvic organs within the three pelvic compartments can be evaluated in reference to PCL as the vertical distance between the resting and strain positions of the urinary bladder neck, the cervix or vaginal apex, and the anorectal junction. Cystocele is defined as a descent of the bladder base below inferior margin of the pubic bone or below PCL, either at rest or during strain (Fig. 6). Cystocele is measured as a vertical distance between the PCL and the most inferior portion of the bladder. Yang et al. [26] demonstrated that the normal vertical distance from PCL to the bladder base at strain should be not more than 1 cm below the line.
Other findings associated with UH that can be detected on MR imaging are distortion of urethral support ligaments, either partial or complete. Partial defects include laxity, fluttering or focal attenuation of ligaments. Complete disruption shows a discontinuity of ligamentous fibers [17, 18]; mostly affected and reproducibly visualized on imaging is PEL. Findings are frequently accompanied by the abnormal vaginal configuration (loss of normal H-shape vaginal contour, or dropping vaginal fornix), best seen on axial images, and widening of para-vaginal attachments (Figs. 7, 8).
The levator ani muscle signal and integrity can be well evaluated on MR images, on axial and coronal T2-weighted images. Levator ani should be symmetric without defects or fraying. Abnormal signal in the levator muscle, when compared to the obturator internus, and thinning can be observed in patients with stress incontinence and can be a result of fatty infiltration and atrophy as well as direct muscle injury [29]. The normal thickness of the puborectalis muscle is 5–6 mm [30]. Interruption of the muscle fibers, lateral deviation of the muscle that is frequently associated with vaginal shape distortion on the affected side, can be observed (Fig. 8).
In patients with UI who do not show signs of pelvic floor laxity, ISD may be responsible for symptoms. There are some imaging findings that are more likely to be associated with ISD, such as a short urethra, urethral muscle thinning or defect (e.g., diverticulum) or bladder neck weakness demonstrated by funneling. The average length of the urethra in continent patients as evaluated with MR imaging is 3.8 cm (SD 0.3 cm) [12]. When the urethra is shorter than 3.0 cm, or when the segment of the urethra above the pelvic floor level is less than 3.0 cm in length, urethral sphincter weakening can lead to incontinence (Fig. 9). Thinning of the urethral striated muscle has been reported in patients with stress incontinence [18]. It has been shown that ISD can be related to decreasing sphincter muscle volume (Fig. 10); however, the quantity of striated muscle also decreases with normal aging. Diverticulum may cause incontinence by weakening the sphincter wall. Urethral diverticulum occurs due to infection of the paraurethral glands, and may or may not communicate with the urethral lumen. Diverticulum in the midurethra usually does not cause UI if the proximal sphincter is intact (Fig. 11). Funneling at the bladder neck, which is the opening of the urethrovesical junction at rest or during strain, can be seen on MR imaging in patients with UI (Fig. 10). An open bladder neck and proximal urethra at rest or strain was shown to indicate an ISD [21]; however, funneling can be also found in some postmenopausal continent women.
MR imaging protocol
Urethral anatomy is best evaluated on T2-weighted images obtained in three orthogonal planes. To achieve the highest resolution and SNR, endocavitary coils can be used [17]. Endovaginal or endorectal coil used with the small field of view, thin slices, and high imaging matrix allow detailed assessment of periurethral anatomy (e.g., periurethral ligament PEL) that can be obscured because of a partial volume averaging effect when imaged with a standard pelvic phased array coil or when imaged in the plane that is not perpendicular to the urethra. The intraurethral coil allows the assessment of the urethral sphincter muscle integrity, as both the smooth and striated muscles are well seen [12]; however, because of its limited anatomical coverage with significant signal drop within 2–3 cm from the coil placed in the urethra lumen, only a small portion of the anatomy can be evaluated with the intraurethral approach. To assess the urethral function during strain, to detect cystocele and to evaluate the levator ani muscles, imaging with the pelvic phased array coil proves to be optimal. Single shot fast spin echo techniques (SSFSE/HASTE) can be used for dynamic pelvic floor imaging when the bladder neck and urethral motion can be registered and subsequently reviewed using a cine display. An example of the imaging protocol for the evaluation of the female urethra is presented in Table 1.
Summary
Sphincteric urinary incontinence is related to urethral hypermobility (UH) and intrinsic sphincter deficiency (ISD). Imaging plays an adjunct role to urodynamics in the assessment of women with UI. MR imaging due to its superior soft tissue contrast resolution contributes many findings that are predictive of UH, where the basic abnormality is weakness of pelvic floor support, such as abnormal descent of the bladder neck, disruption of periurethral ligaments and vaginal attachments, and defects within the levator ani muscle. In ISD, where there is weakness and malfunction of urethral sphincter itself, MR imaging may show foreshortening or thinning of the sphincter muscle and bladder neck insufficiency manifested by funneling. Some patients may demonstrate imaging findings of both UH and ISD, as the ISD with bladder neck funneling may represent a secondary deficiency related to abnormal proximal urethral wall traction and shearing that can overcome urethral coaptation in chronic hepermobility [31]. Currently, MR imaging is considered in the diagnostic work-up of women who failed prior surgeries for incontinence or who have severe and complex pelvic organ prolapse. As we learn more about specific anatomical defects related to UI that can be observed on MR images, the role of MR imaging in primary diagnosis of patient with stress UI is expected to increase.
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Acknowledgment
Work presented in this article was partially supported by the Seed Grant from the Radiological Society of North America and the Young Investigator Award from the Society of Computed Body Tomography and Magnetic Resonance received by KJM.
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Macura, K.J., Genadry, R.R. Female urinary incontinence: pathophysiology, methods of evaluation and role of MR imaging. Abdom Imaging 33, 371–380 (2008). https://doi.org/10.1007/s00261-007-9257-6
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DOI: https://doi.org/10.1007/s00261-007-9257-6