Abstract
Previously, we identified a parathyroid hormone-related high-turnover bone disease after gastrectomy in mini pigs. Dynamic [18F]fluoride ion positron emission tomography (PET) revealed that bone metabolism was significantly increased, but that bone blood flow derived from permeability-surface area product (PS product)-corrected K 1 values was not. Since bone blood flow and metabolism are coupled in normal bone tissues, we hypothesised that the capillary permeability and/or surface area might be altered in high-turnover bone disease. The "true" bone blood flow (f H2O) was measured in vertebral bodies by dynamic [15O]H2O PET, followed by a 120-min dynamic [18F]fluoride ion PET study, 6 months after total gastrectomy (n=5) and compared with results in sham-operated animals (n=5). Estimates for bone blood flow based on PS-corrected K 1 values (f) and the net uptake of fluoride in bone tissue (K i), representing the bone metabolic activity, were calculated using standard compartmental modelling and non-linear fitting. Gastrectomy was followed by a significant elevation of K i and k 3 (P<0.05), which was mainly caused by an increase of the fraction of bound tracer in tissue (P<0.01). In contrast, f H2O, f, the single-pass extraction fraction of [18F]fluoride (E) and the volume of distribution (DV) of [18F]fluoride were not significantly different between groups. In both groups, a coupling of the mean f H2O and K i values was found, but the intercept with the y-axis was higher in high-turnover bone disease. It is concluded that in high-turnover bone disease following gastrectomy, the PS product for [18F]fluoride remains unchanged. Therefore, even in high-turnover bone diseases, [18F]fluoride ion PET can provide reliable blood flow estimates (f), as long as a proper PS product correction is applied. The increased bone metabolism in high-turnover bone disease after gastrectomy is mainly related to an up-regulation of the amount of ionic exchange of [18F]fluoride with the bone matrix, while tracer delivery remains unchanged.
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Received 24 November 2001 and in revised form 9 February 2002
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Piert, M., Machulla, HJ., Jahn, M. et al. Coupling of porcine bone blood flow and metabolism in high-turnover bone disease measured by [15O]H2O and [18F]fluoride ion positron emission tomography. Eur J Nucl Med 29, 907–914 (2002). https://doi.org/10.1007/s00259-002-0797-2
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DOI: https://doi.org/10.1007/s00259-002-0797-2