Abstract
The knee is a complex joint with its function dependent on a combination of osseous and soft tissue structures. Alteration in the relationship of these tissues, due to either acute or chronic repetitive injury with possible underlying congenital predisposing factors, can result in impingement between the structures resulting in pain, particularly on activity. The purpose of this article is to provide a comprehensive review of the MRI features of various impingement syndromes around the knee.
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Introduction
The knee is a complex joint with movements occurring in different planes and in several different axes. The inside of the joint has an intricate arrangement of soft tissues, which facilitate these movements and enable the knee to withstand varying degrees of stress. These soft tissues may be injured, inflamed, or impinged due to strenuous repetitive activity, or if congenitally predisposed from routine daily activity. Patients with impingement problems present with poorly defined knee pain and without clear physical signs. Static imaging is often reported as normal, making it very difficult to establish a diagnosis. Meticulous interpretation of MRI based on a detailed understanding of the structures and pathology is essential for planning appropriate treatment.
Lower limb impingement syndromes in adults and in children have been previously reviewed, without emphasis on the knee joint [1, 2]. Faletti et al. reported their experience of knee impingement syndromes in a sporting population aged 16–55 years in an article which is now over 20 years old and did not emphasize the role of MRI, while more recently Grando et al. reviewed the MRI findings of common intra-articular extra-synovial impingement syndromes but did not consider extra-articular causes of knee impingement [3, 4]. The aim of this article is to provide a comprehensive update of the commoner impingement syndromes around the knee, and to also describe new and rarer knee impingement syndromes. Conditions which are termed ‘friction syndromes’ are also included, as are syndromes which can result in pain from repetitive trauma to various intra-articular structures such as the synovial plicae although the terms ‘impingement’ and ‘friction’ have not been specifically used to describe them. We have classified knee impingement syndromes into the 4 quadrants of the knee joint (anterior, medial, posterior, and lateral) as previously described, with further subdivision according to intra-capsular or extra-capsular sources of knee pain as shown in Table 1 [3].
Anterior
Extra-capsular: pre-patellar friction syndrome
In 2003, Dye et al. described the tri-laminar structures of the pre-patellar soft tissues [5]. The superficial layer was orientated transverse to the patella. The intermediate layer, arising from the expansion of the vastus medialis and lateralis with some contribution from the superficial fibres of rectus femoris, was orientated oblique to the patella, while the deep layer was formed by the continuation of the deep fibres of the rectus femoris and was adherent to the underlying bone in a longitudinal orientation. This layer continued inferiorly to become part of the patellar tendon. A small amount of bursal fluid was noted between all three layers, helping to reduce friction. This tri-laminar anatomy is evident on MRI [6].
In 2015, Claes et al. described pre-patellar friction syndrome, an entity observed in a series of 29 surgically operated patients brought on by repetitive motion causing the superficial and intermediate layers to rub against the fixed deep layer [7]. The pathology was seen exclusively in young professional cyclists with anterior knee pain during physical exertion, with or without a history of preceding trauma. There was point tenderness over the superior pole of the patella, mostly at the medial aspect. At surgery, all patients had a defect in the thinnest superficial layer, with or without a further defect in the more robust intermediate layer. The deepest layer only demonstrated inflammation, but no tears. Ultrasound was able to demonstrate the fascial defects, and although the MRI features have not been formally reported, oedematous swelling of the pre-patellar soft tissues would be expected (Fig. 1). It is important to identify this condition on MRI as opposed to simple pre-patellar bursitis, since the condition responds well to partial pre-patellar fasciectomy [7].
Intra-capsular: fat pad impingement
Three distinct areas of adipose tissue called ‘fat pads’ have been defined in the anterior aspect of the knee joint: the infrapatellar (Hoffa’s), the suprapatellar (quadriceps), and the pre-femoral fat pads. These intra-capsular, extra-synovial structures act as protective cushions that accommodate the changing shape and volume of the spaces they occupy during movements of the knee joint [8, 9].
Hoffa’s fat pad
Hoffa’s fat pad is limited anteriorly by the patellar tendon and joint capsule, superiorly by the inferior pole of the patella, inferiorly by the proximal tibia and the deep infrapatellar bursa, and posteriorly by the joint synovium [10]. It is made up of fat lobules with multiple septa. Hoffa’s fat pad is richly innervated via branches of the femoral, common peroneal and saphenous nerves, and therefore, pathology of the fat pad can be a source of anterior knee pain. It is an important structure, as evident by altered patellar biomechanics following its resection [11]. The infrapatellar plica, a remnant of the synovial membranes also known as the ligamentum mucosum, runs through the fat pad between the anterior aspect of the femur and the inferior pole of the patella. It is the most common plica identified on arthroscopy [12]. Pain arising from Hoffa’s fat pad is usually secondary to other knee pathology, and may also occur after knee arthroscopy. However, three types of impingement have been described.
The commonest type occurs in the superolateral aspect of the fat pad and is termed patellar tendon-lateral femoral condyle friction syndrome [13, 14]. It is typically seen in young patients with a higher incidence in females, although it can also occur in older individuals [15]. Patients typically present with anterior or anterolateral knee pain which is commonly exacerbated by hyperextension. Physical examination may demonstrate focal point tenderness at the inferior pole of the patella [9]. MRI demonstrates increased signal on T2-weighted fast spin-echo (T2W FSE) or fat-suppressed proton density–weighted fast spin-echo (PDW FSE) images, with corresponding reduced signal on T1-weighted spin-echo (T1W SE) or PDW FSE images (Fig. 2) [14]. The abnormal signal may extend into the central superior aspect of the fat pad, and injection of contrast medium always results in enhancement [16, 17]. A minority of patients may demonstrate appearances of a lobular lesion with fluid/cystic signal change (Fig. 3), and abnormality of the adjacent patellar tendon is not uncommon [14, 18].
Multiple studies have correlated superolateral Hoffa’s fat pad oedema with various parameters of patellofemoral maltracking, including patella alta (Insall-Salvati index > 1.3), lateral patellar subluxation (increased tibial tubercle-trochlear groove distance), shallow trochlear depth, sulcus angle, lateral trochlear inclination angle, lateral patellofemoral angle, lateral patellar translation, and the distance between the patellar tendon and the most anterior margin of the adjacent femoral condyle [14, 15, 18,19,20,21,22,23]. It is important to highlight that while the studies have shown statistically significant differences regarding the various measurements of patellofemoral maltracking between patients with and without oedema in the superolateral aspect of the fat pad, these measurements do not always fall outside the normal range of values described in the literature [21]. Similar signal abnormality can also be seen in asymptomatic patients, particularly in athletes when it may be bilateral. This may still be due to subtle patellofemoral maltracking, but will not require any treatment [17, 24].
The second type of impingement is called Hoffa’s disease and is related to injury which may be either acute, or chronic and repetitive in nature. First described by Albert Hoffa in 1904, the injury causes haemorrhage and inflammation resulting in hypertrophy of the fat pad and impingement between the tibia and femur during knee extension [13, 25]. Impingement causes further trauma to the fat pad resulting in a continuous cycle of inflammatory response. In the chronic stage, there is fibrosis within the fat pad, with occasional metaplasia resulting in ossification. Patients typically present with pain in the infrapatellar or retro-patellar region, loss of normal hyperextension, and positive Hoffa’s test (tenderness on palpation of the fat pad on either side of the patellar tendon as the knee moves from 90° flexion to full extension) [26]. On MRI, acute changes result in hyperintensity within Hoffa’s fat pad on fat-suppressed PDW FSE or T2W FSE images, with corresponding hypointensity on T1W SE images [27]. The oedema is more common in the superior or posterior region of the fat pad (Fig. 4), and other MRI features include a fluid-filled deep infrapatellar bursa, non-visualization of vertical and/or horizontal clefts, fibrosis, and calcifications [28]. The fat pad may be enlarged with anterior bowing of the patellar tendon due to mass effect [16]. Chronic cases may show fibrosis with low signal on T1 and T2W images, while radiographs can demonstrate calcification within the fat pad (Fig. 5) [29]. Oedema and scarring of Hoffa’s fat pad may also be seen in association with acute and chronic anterior cruciate ligament injury, the resulting knee instability potentially resulting in fat pad impingement which typically involves the region around the ligamentum mucosum [30].
The third type of impingement that may affect Hoffa’s fat pad is related to the infrapatellar plica and is termed posterior Hoffa’s fat pad impingement. Plicae are normal folds of synovial tissue found in the lining of the knee joint and are (in order of decreasing frequency) the infrapatellar plica (ligamentum mucosum), the suprapatellar plica, the medial (mediopatellar) plica, and the lateral plica [31]. The suprapatellar plica is considered to be a septal remnant between the suprapatellar bursa and patellofemoral cavitation, which is the precursor for the patellofemoral joint space. The infrapatellar plica is a remnant of the septum between the medial and lateral tibiofemoral compartments, but the medial plica is not associated with any distinct compartment [32]. The reported incidence of plica is variable, ranging from 21% for various types of plica to as high as 80% for medial plica, while 11% of the knees may have all 3 main types of plicae and 10% do not have any plicae at all [33, 34]. On MRI, a normal plica is seen as a thin band of low signal intensity within the hyperintense joint fluid, optimally demonstrated on fat-suppressed T2W FSE, PDW FSE, or T2W gradient-echo (GRE) sequences [35]. Plica syndrome is defined as painful knee impairment when the only imaging finding to explain the symptoms is the presence of an abnormal plica [36]. It may be caused by direct injury, repetitive/overuse injury, or a variety of inflammatory conditions. However, most cases of plica syndrome are idiopathic [37].
The infra-patellar plica may undergo thickening and fibrosis and become symptomatic, causing anterior knee pain and restriction of movement by impinging at the intercondylar notch and trochlea [38]. On MRI, there is high signal on fat-suppressed PDW FSE or T2W FSE images along the expected course of the infrapatellar plica, with chondromalacia occurring at the superior aspect of the intercondylar notch and on the patellofemoral sulcus [39, 40]. Similar to Hoffa’s disease, the abnormality is related to either acute injury or repetitive trauma, and there may be clinical and imaging overlap with Hoffa’s disease [13, 41, 42]. It is therefore considered a diagnosis of exclusion.
Pre-femoral fat pad
The pre-femoral fat pad, also known as the posterior suprapatellar fat pad, is located anterior to the distal femur and superior to the trochlea, being separated from the quadriceps fat pad by the suprapatellar bursa [43]. Two different patterns of oedema have been described within the pre-femoral fat pad. One occurs at the superior aspect close to the midline and is believed to be caused by impingement of the fat pad due to a prominent suprapatellar osteophyte. Scalloping of the anterior femur and fibrous or cartilaginous metaplasia may also be seen (Fig. 6) [43]. The second occurs in the inferolateral part of the fat pad and is found to be associated with patellar tendon-lateral femoral condyle friction syndrome, with impingement of the fat pad occurring between the superior aspect of the patella and the distal femur [9, 14, 19]. MRI shows oedema and enlargement of the fat pad with high signal on fat-suppressed PDW FSE or T2W FSE images and low signal intensity on T1W SE images (Fig. 7) [44]. Some consider the association between pre-femoral fat pad oedema and anterior knee pain to be controversial, as it can also be an asymptomatic finding in high-level athletes [9, 45].
Quadriceps fat pad
The quadriceps (suprapatellar) fat pad is a small triangular structure located superior to the patella, deep to the quadriceps tendon, and separated from the pre-femoral fat pad by the suprapatellar bursa [43]. Oedema within the suprapatellar fat pad is a common finding on MRI, although its association with anterior knee pain is controversial. Enlargement of the quadriceps fat pad has been demonstrated in 12% of knee MRI studies (Fig. 8a, b), with signal alteration in 54%. A significant association with anterior knee pain and an enlarged fat pad has been suggested [46]. However, a larger retrospective review of 879 knee MRI studies reported an incidence of suprapatellar fat pad enlargement of 13.8% of cases which was rarely associated with anterior knee pain, and there was also no association with patellofemoral malalignment [8]. Finally, Shabshin et al. identified quadriceps fat pad oedema with mass effect in 4.2% of 770 consecutive knee MRI examinations, also demonstrating that symmetrical oedema may be seen in the contralateral knee and that the fat pad enhances following contrast (Fig. 8c) [47].
While the term impingement has been used for suprapatellar fat pad oedema, based on histological changes and the higher incidence in young males, it is considered to be similar to Hoffa’s disease representing an overuse injury causing oedema and haemorrhage in the suprapatellar fat pad, rather than being due to impingement [8, 47]. More recently, an association between suprapatellar fat pad oedema and mass effect with subsequent knee osteoarthritis, particularly at the patellofemoral joint, has been identified [48, 49].
Intra-capsular: suprapatellar plica
The suprapatellar plica has also been described as the superior plica, plica synovialis suprapatellaris, superomedial plica, or medial suprapatellar plica [31]. It is located in the suprapatellar region and runs from the synovium at the anterior aspect of the femoral metaphysis to the posterior aspect of the quadriceps tendon, inserting above the patella. It is the most common type of plica, being found in approximately 90% of knees, with various classifications ranging from 4 to 10 different morphological appearances [31, 50,51,52]. The plica may not demonstrate a septum, but if present, the septum can be complete or incomplete. When complete, the intact septum separates the knee joint cavity from the suprapatellar bursa.
A symptomatic suprapatellar plica is a rare occurrence, associated with inflammation which may be triggered by either acute or repetitive injury [53]. Patients present with dull knee pain aggravated by prolonged standing and/or squatting, with point tenderness at the superior pole of the patella [50, 54]. A plica with a complete septum is typically symptomatic. MRI shows a low signal intensity band-like structure in the retro-patellar space, optimally seen on sagittal images (Fig. 9). The abnormal plica can become compressed between the quadriceps tendon and femoral condyle during flexion, resulting in impingement with secondary chondromalacia at the patellofemoral joint [55]. MRI is helpful in identifying the abnormal plica, as well as excluding other underlying causes.
Medial
Extra-capsular: medial tibial crest friction
Medial tibial crest friction was first described in 2013, the condition being seen predominantly in young adults with a high level of physical activity, particularly athletes [56]. Patients typically complained of pain and tenderness approximately 2.5 cm below the medial joint line. It is suggested that prominence of the medial tibial crest due to a reduced medial tibial crest angle results in friction between the tibial collateral ligament and the adjacent bone, causing bone and soft tissue oedema. MRI demonstrates hyperintense signal on fat-suppressed PDW FSE images at the medial tibial crest and adjacent soft tissue in all patients, the oedema occurring where the tibial collateral ligament contacts the proximal tibia (Fig. 10). The medial tibial crest angle calculated on the coronal images demonstrated a difference of 8.1° between patients (151.3° ± 9/3°) and controls (159.4° ± 7.2°) [56].
Extra-capsular: posteromedial friction syndrome
Posteromedial friction syndrome is thought to be due to approximation of the posteromedial femoral condyle and the adjacent sartorius and gracilis tendons, although other factors such as concomitant lateral friction syndromes may contribute [57]. Patients complain of medial joint pain which may mimic a meniscal tear, with positive McMurray’s test reported in 21% of cases. MRI demonstrates a significantly reduced space between the posteromedial femoral condyle and the adjacent sartorius and gracilis tendons, and a varying degree of oedema of the fat between the condyle and the adjacent tendons (Fig. 11). The oedema is usually deep to both tendons, less commonly deep only to gracilis, and rarely deep only to sartorius. Bone marrow oedema may also be visible in the non-weight-bearing portion of the posteromedial femoral condyle. Lateral-sided friction syndrome is present in approximately 25% of cases, patellar tendon-lateral femoral condyle friction syndrome being the commonest. The condition may respond well to local anaesthetic and steroid injection [58].
Intra-capsular: medial plica syndrome
The medial plica is the most commonly symptomatic plica [31]. Four types of medial plica are described. Types A and B do not cover the medial patellofemoral articular surface, while types C and D extend to cover the articular surfaces and are therefore more likely to be symptomatic. Typically, pain is experienced medial to the patella with clinical signs such as crepitation, pseudo-locking, and effusion-mimicking symptoms of a meniscal tear or patellar maltracking. Oedema and inflammation result in loss of normal elasticity of the plica, causing it to become thickened and fibrotic [59]. Symptoms may be related to the thickened oedematous plica itself, or from impingement on the cartilage at the medial femoral condyle in extension and medial patellar facet in flexion [35]. MRI demonstrates a thickened irregular plica, covering the medial aspect of the patellofemoral joint (Fig. 12). Associated cartilage defects are seen in the medial patellofemoral joint in 30% of patients [60, 61].
Intra-capsular: meniscal impingement syndromes
Various types of meniscal impingement have been described, predominantly related to the medial meniscus. These are due to either variations of underlying bone morphology, increased joint mobility, or peripherally displaced meniscal tears. Some conditions described in the orthopaedic literature cannot be demonstrated on routine knee MRI, and are therefore not included.
Morphological factors may predispose to meniscal impingement and tears. In a retrospective analysis of 160 knee MRI studies of 150 patients, medial and lateral tibial slope, medial tibial plateau depth, and medial and lateral femoral condylar offset ratio were measured and correlated with the presence and location of meniscal tears. A significant association was shown between reduced medial tibial slope and tears in the posterior third of the medial meniscus, the combination of shallow medial tibial slope, and the relatively immobile posterior third likely contributing to meniscal impingement on knee flexion. A significant association was also identified between tears of the anterior third of the lateral meniscus and a shallow lateral tibial slope [62].
Osteomeniscal impingement, also termed osteomeniscal impact oedema (OIE), is a distinct entity manifest by a peripherally displaced flap tear of the medial meniscus with adjacent reactive bone marrow oedema [63, 64]. Patients typically complain of medial knee pain, particularly with knee flexion and valgus stress, as a result of impingement of the meniscal fragment against the bone under an intact medial collateral ligament [65]. Displacement into the inferior medial gutter (Fig. 13a) is more common compared with superior displacement (Fig. 13b). Apart from identifying the displaced meniscal fragment and adjacent oedema, MR may also demonstrate focal bone depression. It is important to identify flap tears with osteomeniscal impingement, as patients may respond well to arthroscopic debridement of the displaced meniscal fragment [63, 66].
Posterior
Intra-capsular: peri-cruciate fat pad inflammation
The peri-cruciate fat pad is a triangular-shaped structure located in the intercondylar fossa above the posterior cruciate ligament and posterior fibres of the anterior cruciate ligament. It is an intra-capsular, extra-synovial structure which is best identified on sagittal MR images [67].
Peri-cruciate fat pad inflammation presents as non-specific posterior knee pain, predominantly in young patients with a high level of physical activity. Impingement of the fat pad in knee flexion has been proposed as a possible mechanism of injury/inflammation. MRI demonstrates a poorly defined oedema in the peri-cruciate fat pad on fluid-sensitive fat-suppressed sequences, best appreciated on sagittal and axial images (Fig. 14). The oedematous fat pad will enhance following contrast. The condition is a diagnosis of exclusion, which can be suggested when no other pathology is demonstrated to account for the patient’s symptoms.
Lateral
Extra-capsular: iliotibial band friction syndrome
The iliotibial band is a tri-laminar structure consisting of superficial, intermediate, and deep layers which merge together at the level of the greater trochanter receiving fibres from the gluteus maximus and tensor fascia lata muscles [68, 69]. In the distal thigh, it runs close to the lateral femoral condyle, attaching to the intermuscular septum and supracondylar tubercle of the femur proximal to the knee joint. Distally, it inserts into Gerdy’s tubercle on anterolateral tibia. The space between the iliotibial band and the lateral femoral condyle contains fatty and vascular connective tissue [70]. Contrary to the earlier suggestion of the band moving forwards and backwards in flexion and extension respectively, Fairclough et al. have shown that the band is compressed against the epicondyle in 30° of flexion and moves laterally on extension [71].
Iliotibial band friction syndrome was first described in 1975 in military personnel presenting with lateral knee pain, being subsequently reported in athletes a few years later [72, 73]. The incidence of iliotibial band friction syndrome ranges from 1.6 to 12% [74]. Various aetiologies have been proposed, including friction induced by the band as it moves over the lateral epicondyle of the femur, and compression of the fat and connective tissue between the band and adjacent condyle [74]. Structural abnormalities have also been implicated, including gait abnormality, leg length discrepancy, and varus deformity of the knees [74, 75].
The diagnosis of iliotibial band friction syndrome is based on history and clinical symptoms, with tenderness over the lateral aspect of the knee, inferior to femoral condyle but above the joint line [76]. However, other conditions such as lateral meniscal tears, lateral collateral ligament sprain, and popliteus tendon strain may mimic symptoms of iliotibial band friction syndrome [77]. Therefore, MRI is helpful in making the appropriate diagnosis. The most common MRI finding is an ill-defined area of hyperintense signal on fat-suppressed PDW FSE/T2W FSE coronal and axial images deep to the iliotibial band and lateral, proximal, or distal to the femoral condyle (Fig. 15). The signal abnormality can also be seen posterolaterally between by the femur and the anterior margin of biceps femoris. Oedema superficial to the iliotibial band is uncommon in friction syndrome being typically associated with acute trauma, and there is usually no thickening of the band itself [75, 78]. Rarely, oedema-like marrow signal may be seen in the adjacent lateral femoral condyle (Fig. 16) [79]. A circumscribed fluid collection may be observed deep to the iliotibial band and separate from the suprapatellar pouch in approximately 30% of patients, which can be as large as 5 cm in keeping with adventitial bursitis as a result of chronic inflammation [70].
Intra-capsular: popliteus tendon impingement
The popliteus musculotendinous unit is a major stabilizer of the posterolateral knee [80]. The muscle originates from a strong intra-capsular tendon at the lateral condyle of the femur, coursing inferomedially within the popliteal fossa and inserting into the posterior surface of the tibia above the soleal line. The popliteofibular ligament anchors the popliteus to the fibular head, and the tendon has variable attachments to the lateral meniscus.
Impingement of the popliteus tendon is an extremely rare cause of lateral knee pain, typically occurring secondary to osteophyte formation at the lateral femoral condyle [81]. The pain is typically related to physical activity causing an abnormal movement of the popliteus tendon against the osteophyte. The tendon may appear thickened and inflamed at arthroscopy, which also allows direct visualization of the tendon impinging on the osteophyte. MRI demonstrates swelling and hyperintensity of the tendon to its insertion at the lateral femoral condyle consistent with tendinosis, and oedema of the surrounding soft tissues (Fig. 17).
Summary
A wide variety of impingement and friction syndromes can occur around the knee, mimicking meniscal and ligamentous conditions in the setting of acute and chronic sports injuries. Knowledge of the MRI appearances is essential to allow correct diagnosis and management.
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Khan, I., Ashraf, T. & Saifuddin, A. Magnetic resonance imaging of impingement and friction syndromes around the knee. Skeletal Radiol 49, 823–836 (2020). https://doi.org/10.1007/s00256-020-03379-y
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DOI: https://doi.org/10.1007/s00256-020-03379-y