Abstract
Calvarial lesions often present themselves as clinically silent findings on skull radiographs or as palpable masses that may cause localized pain or soreness. This review aims to explore the radiographic, computed tomography (CT), and magnetic resonance imaging (MRI) characteristics of calvarial neoplastic, inflammatory, and congenital lesions that are common in adults in order to facilitate a structured approach to their diagnosis and limit the differential diagnosis. In addition to reviewing the literature, we reviewed the records of 141 patients of the Montreal Neurological Institute and Hospital with radiologically documented calvarial lesions between 2001 and June 2009. CT is ideal for detecting bony lesions and is helpful in precisely localizing a lesion pre-surgically. MRI is best at identifying intradiploic lesions before they affect the cortical tables and is able to establish extraosseous involvement, especially when paramagnetic contrast is employed.
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Calvarial lesions often present themselves as clinically silent findings on skull radiographs or as palpable masses that may cause localized pain or soreness. Since a variety of neoplastic, inflammatory, congenital, and traumatic etiologies can give rise to such lesions, an organized approach to their diagnosis is essential. To achieve an accurate diagnosis is important because although most calvarial lesions are benign, those that are malignant require adequate therapy [1].
Radiography is often the first imaging modality used to evaluate a calvarial lesion and can often suggest a diagnosis [2]. Computed tomography (CT) and/or magnetic resonance imaging (MRI) commonly follow. CT is ideal for detecting bone lysis and sclerosis, determining the involvement of each of the two skull tables and the diploë, and is helpful in precisely localizing and delineating a lesion pre-surgically. CT can also demonstrate calcification within a lesion and the presence of sclerotic margins. MRI is able to show intradiploic lesions before they erode the cortical tables; moreover, if the radiographs suggest soft tissue or intraaxial involvement, then MRI is preferable due to its ability to establish extraosseous involvement, especially when paramagnetic contrast is employed [3].
This review explores the radiographic, CT, and MRI imaging characteristics of neoplastic, inflammatory, and congenital lesions that are common in adults (18 years and older) in order to facilitate a structured approach to their diagnosis.
For this review, we reviewed the images of all the patients of the Montreal Neurological Institute and Hospital (MNI) with radiologically documented calvarial lesions between 2001 and June 2009. We reviewed 141 lesions that either directly affected or secondarily affected the calvaria. Of these, 54 lesions (38%) had surgical or pathologic correlation and are herein used to illustrate the imaging qualities of the various lesions. The most common lesions encountered were: 32 osteomas (23%); 22 eosinophilic granulomas or Langerhans cell histiocytoses (16%); 18 hemangiomas and meningiomas each (13% each); 14 fibrous dysplasias and metastases each (10% each); six squamous or basal cell carcinomas (4%); five multiple myelomas (4%); and 12 other lesions (9%). Other lesions include: epidermoid cyst (four), lipoma (two), dermoid cyst (one), ossifying fibroma (one), hemangiopericytoma (one), lymphoma (one), and aneurysmal bone cyst (one). Eleven cases of Paget’s disease, none of which featured sarcomatous transformation, were also encountered. Meningiomas, hemangiopericytomas, and squamous or basal cell carcinomas typically invade the calvaria secondarily, whereas all of the other aforementioned lesions originate from within the calvaria.
Radiological approach to the evaluation of calvarial lesions
Anatomy and imaging
The calvaria comprise the frontal bone, parietal bones, occipital bone, squamous and zygomatic portions of the temporal bones, and the tips of the greater wings of the sphenoid bones [4]. In terms of layers, the inner and outer tables of cortical bone sandwich the diploë, which contains cancellous bone and bone marrow. Some lesions may extend beyond these three layers into the scalp or the meninges. Other lesions originate in the scalp or meninges and invade the adjacent bone. Some calvarial lesions have a partiality towards particular bones, and many have a tendency to involve extraosseous components.
On CT, the calvaria is best evaluated using a bone algorithm or at least when viewed using bone windows. On MRI, the cortical tables appear as signal void on both T1-weighted images (T1WI) and T2-weighted images (T2WI). In adults, the marrow has high signal intensity on T1WI due to the high fat content. In adolescents, the marrow signal is more heterogeneous because the marrow is not yet completely replaced with fat; nonetheless, the signal tends to be bilaterally symmetrical [4]. Except for diploic veins and meninges adjacent to Pacchionian granulations, the diploë does not normally enhance with contrast [5].
Certain imaging signs indicate that a lesion is extraaxial (i.e., lies outside the brain parenchyma). Typically, extraaxial masses cause local bony changes [6]. The next most reliable sign is the displacement of pial arteries or veins away from the bone or dura. White matter buckling, which describes the process whereby the white matter is compressed while the edema-resistant grey matter is spared, is unique to extraaxial lesions [7]. Furthermore, on MRI, a CSF cleft, which is hypointense on T1WI and hyperintense on T2WI, can be found between the lesion and the brain.
Borders of the lesion and types of bone destruction
A lesion’s borders and its type of bone destruction are indicative of its growth rate and consequently its benignity or malignancy. A clearly demarcated lesion with a narrow zone of transition and a uniform area of destruction suggests slow growth, whereas an ill-defined margin with a wide zone of transition and permeative destruction suggests a more aggressive lesion [8]. The development of a sclerotic margin suggests a long-standing lesion with “remodeling” behavior while the absence of a sclerotic border is more consistent with an aggressive process.
Periosteal response
The outer table is covered by periosteum and the periosteum of the inner table is included in the dura. Calvarial lesions are not typically associated with a periosteal reaction because the periosteum cannot be identified on CT or MRI [4].
Soft tissue and dural extension
The cortical tables may contain slow-growing lesions; however, aggressive lesions may extend through destroyed bone into soft tissue, dura mater, and/or brain parenchyma [8]. On MRI, the dura mater adjacent to malignant lesions is often thickened and often enhances after contrast administration, reflecting the lesion’s tendency to invade or inflame it [9, 10]. Dural enhancement can also reflect a benign lesion or even normal meninges [11]. Nodular, discontinuous enhancement is associated with invasion, whereas continuous, linear enhancement is typically an expression of a reactive change. A thin hypointense line between the lesion and the enhanced dura implies the persistence of the potential epidural space, which itself suggests that the dura mater remains uninvaded [12].
Calvarial lesions
Eosinophilic granuloma
Langerhans cell histiocytosis (LCH) encompasses three idiopathic diseases that are characterized by proliferation of Langerhans cells [13]. When it is solitary and monostotic, as is most often the case, the lesion is referred to as an eosinophilic granuloma. LCH occurs most commonly in children and adolescents and its severity is inversely related to the age of onset. The lesion’s quick progression and rapid regression are salient features. The calvaria is the most common site for LCH, with the parietal bones most frequently affected.
The lesion is usually lytic with well-defined non-sclerotic borders and involves all three layers of the skull (Fig. 1). A sclerotic margin may appear if the lesion begins to regress, as normal bone replaces the inflammatory cell infiltrate [14]. The beveled edge or double-contoured appearance of the lesion, which is caused by uneven destruction of the two cortical tables, is highly suggestive of LCH on skull radiographs [4]. The granulomas are slightly denser than grey matter on CT [15]. Residual bone, referred to as a “button sequestrum,” may be present in the osteolytic lesion but is a relatively uncommon finding in our experience. On MRI, the lesion appears hypo-isointense to grey matter on T1WI and heterogeneously hyperintense on T2WI. It enhances markedly. The adjacent dura usually enhances as well, but is rarely penetrated [16, 17]. As opposed to eosinophilic granuloma of the appendicular skeleton, that of the calvaria does not appear to be associated with edema of the surrounding marrow and soft tissue, as none of the nine eosinophilic granulomas imaged with MRI herein reviewed featured surrounding edema. In our experience, when the diagnosis of eosinophilic granuloma is suspected but tentative, a follow-up CT is helpful in affirming the diagnosis because spontaneous resolution is common.
Epidermoid and dermoid
Both epidermoids and dermoids are congenital unilocular ectodermal inclusion cysts lined by an epithelium. Epidermoid cysts are filled with debris (keratin and cholesterol) from the desquamation of their thin squamous epithelial lining whereas dermoid cysts are lined by a thicker epithelium and filled with sebaceous, sweat and apocrine glands, hair, and less commonly, teeth. Epidermoids tend to present more laterally and during the third and fourth decades of life while dermoids usually present closer to the midline or around the orbit and during the second and third decades of life [18].
Radiographically, intradiploic epidermoid and dermoid cysts erode and may expand both the inner and outer tables of the calvaria and typically feature a smooth sclerotic rim pursuant to bone remodeling (Fig. 2). On CT, epidermoids are homogeneous and are similar in density to cerebrospinal fluid. Dermoids differ in that they are more heterogeneous and may display calcification along their wall or internally [19, 20]. On MRI, epidermoids are invariably hyperintense on T2WI and of variable intensity on T1WI. In contrast, most dermoids have the signal intensity characteristics of fat on MRI due to their oily sebaceous secretions (Fig. 3). As such, they are often hyperintense on both T1 and T2WI. Neither the wall nor the interior of the epidermoid enhance upon contrast administration on CT or MRI. The wall of the dermoid, however, may enhance, as it is often somewhat vascularized [21].
Hemangioma
Hemangiomas are benign blood vessel tumors with a higher predilection for women in the middle decades of life [22]. They are most often seen solitarily in the frontal and parietal bones but can affect any region of the calvaria. Most calvarial hemangiomas are histologically classified as cavernous, meaning that they are composed of dilated blood vessels contained within the bony trabeculae.
The calvarial hemangioma is radiographically characterized by a lytic lesion with a “sunburst” or “honeycomb” trabecular matrix radiating from a common center (Fig. 4). The trabecular pattern, which is not invariably present, may be the result of osteoclastic activity pursuant to the stress caused by vascular neoplasia and the ensuing osteoblastic remodeling [23]. Originating intradiploically, the lesion usually expands the outer table, thus often eroding it and leaving the inner table intact. As it grows further, the inner table can be displaced as well, and may also become eroded. It is usually sharply separated from normal bone and a reactive sclerosis is present in approximately 30% of cases. MRI T1WI shows a mottled isointense lesion within the diploic space with scattered hypo-and hyperintensities corresponding to iron storage complexes and fatty tissue, respectively. T2WI reveals a hyperintense lesion, indicating the presence of the aforementioned iron storage complexes [24]. A larger lesion may show more hypointense foci secondary to thickened trabeculae. During rapid serial MRI, hemangiomas show a characteristic imaging enhancement pattern in that they enhance in focal areas during the early phase and enhance diffusely during the later phase. The adjacent meninges may also enhance [25]. In our experience, smaller hemangiomas may be more difficult to distinguish from eosinophilic granulomas, probably because the lesion’s sunburst matrix seems to be less apparent when the lesion is relatively small.
Meningioma
Meningioma represents the most common benign intracranial neoplasm. This tumor arises from the meningothelial cells and usually forms a unilobular mass with a broad-based dural attachment [26]. Meningiomas are less commonly malignant. The parasagittal region is a common site. It may cause surrounding edema by pressuring the subjacent parenchyma. Bony changes occur in approximately one-quarter of meningiomas [27]. Hyperostosis (bone formation) is the most common bony change, but bone destruction sometimes also occurs. Plaque meningiomas coat the inner table and are more likely to cause hyperostosis than the more pedunculated globular sort. These plaque meningiomas are relatively prone to infiltrating the underlying dura and overlying bone. About 1% of meningiomas originate ectopically within the diploë. These are commonly referred to as intraosseous meningiomas [28].
CT typically shows a round or smoothly lobulated mass that appears hyperdense to brain parenchyma in 75% of cases and isodense in the rest (Fig. 5). Focal, diffuse, rim-like or punctate calcification is seen in 20% of cases [27]. Contrast-enhanced CT generally shows intense, uniform enhancement, but 10–15% of cases show an atypical pattern [29]. On T1WI, it is usually hypo-isointense, while on T2WI it is usually iso-hyperintense, and sometimes heterogeneous. It enhances homogeneously and often exhibits a dural tail. Enhanced MR images are particularly able to detect small meningiomas that appear isointense on other MR images. The dural tail sign, which describes peritumoral-enhanced dura, is suggestive of, but not specific to, meningiomas [9]. Intraosseous meningiomas usually extend through the cortical tables into the adjacent soft tissues. The intraosseous meningioma can be radiologically indistinguishable from the plaque variety if by the time of presentation, the intraosseous meningioma has already infiltrated the dura. In these cases, the true origins of the tumor cannot be stated with certainty [30]. Nonetheless, prominent hyperostosis and minimal intracranial presence are more suggestive of the intraosseous sort while associated edema is more suggestive of the plaque variety.
Hemangiopericytoma
Hemangiopericytomas, which can arise from pericytes around the meninges, are low-grade malignant tumors that typically present in young people [31]. The pericytes around the meninges are particularly prone to neoplastic changes and as such, calvarial hemangiopericytomas are often misdiagnosed as malignant meningiomas. Moreover, they have a predilection for the same sites as meningiomas, such as the parasagittal region. Hemangiopericytomas have a particular tendency towards delayed extraneural metastasis, with an average period of 99 months before metastasis. About three-quarters of them metastasize by 15 years post-resection [32]. The same biologic behavior can apply to those lesions mistakenly labeled as malignant meningiomas, which may be rediagnosed as hemangiopericytomas following a skeletal metastasis [33].
Meningeal hemangiopericytomas, in contrast to meningiomas, do not exhibit calcification, frequently cause bony erosion, and almost never cause hyperostosis (Fig. 6). Their irregular or lobulated borders and heterogeneous enhancement pattern reflect their aggressive nature. There is less often peritumoral edema in hemangiopericytomas. Furthermore, although meningiomas may have internal vascular signal voids, this finding is more common in hemangiopericytomas [34].
Fibrous dysplasia
Fibrous dysplasia is a genetically based sporadic disorder haracterized by the replacement of normal cancellous bone with abnormal fibrous tissue containing immature woven bone [8]. This benign lesion typically occurs in adolescents and young adults and may involve a single bone (monostotic) or multiple bones (polyostotic). Fibrous dysplasia of the calvaria usually affects the frontal or temporal bones [35].
The woven bone component of the lesion results in the characteristic radiographic “ground glass” appearance (Fig. 7). All cases described in the literature demonstrate some degree of this hazy, intradiploic density on CT, making CT the investigation of choice and the most useful diagnostic tool for fibrous dysplasia in our experience. The radiographic density corresponds to the degree of mineralization of the lesion. The lesion usually causes the outer table to bulge outward while conserving the shape of the inner table [17]. Moreover, it is usually bound by a prominent sclerotic margin [36]. It is hypointense on T1WI, but more fibrous areas tend to relatively isointense. The T2WI appearance is heterogeneous and variable, with more fibrous areas that include fewer bony trabeculae and less cellularity showing high signal and low signal indicating a more osseous and cellular matrix. A peripheral black ring representing the sclerotic border is typically seen on MRI. Contrast enhancement is also variable: it can be homogeneous, central, or affect only the periphery [37]. In this pathology, MRI is most valuable in delineating the full extent of the lesion.
Osteoma
Osteoma is a benign, painless, slow-growing tumor comprising mature bone. It represents the most frequent calvarial tumor, and in our series, was almost invariably discovered incidentally [4]. It most commonly grows from the outer table of the calvaria, but can also originate from the inner table.
Osteomas appear as intensely homogeneous dense round (or oval) lesions on radiographs and CT, with the density being dependent upon the proportion of compact to cancellous bone. They emanate from one of the cortical tables and a bony stalk is usually observed (Fig. 8) [38]. They are homogeneously hypointense on T1WI and heterogeneously hypointense on T2WI and show no contrast enhancement. They do not disturb the diploë.
Metastases
In contrast to those of the skull base, metastases to the skull vault are usually asymptomatic, but may still cause pain by irritating the pain-sensitive periosteum [39]. In adults, breast, lung, prostate, renal, and thyroid cancers and melanoma are the primary tumors that most commonly metastasize to the calvaria (in descending order) [40]. Calvarial metastases are usually diagnosed in the setting of a known malignancy. We encountered 14 cases of calvarial metastases, of which seven were the initial location of skeletal metastasis and three were the first evidence of an undiagnosed primary.
On radiographs and CT, metastatic deposits are most often osteolytic with ill-defined margins and an associated soft-tissue extension (Fig. 9). Metastases secondary to prostate cancer and osteosarcoma, in contrast, are predominantly osteoblastic, albeit with less hyperostosis than a meningioma [41]. Lung metastases demonstrate both a lytic and a blastic response, with the latter more prominent in response to effective chemotherapy [42]. Although calvarial metastases are sometimes solitary, there are usually multiple infiltrations. MRI, importantly, more clearly identifies small lesions, especially when contrast-enhanced. On T1WI, metastatic infiltrations appear hypointense to the background marrow in adults. Moreover, all areas of diploic enhancement (other than diploic veins and arachnoid granulations) can be interpreted as possible metastases. These areas of enhancement are most readily seen on fat-suppressed T1WI [5]. Osteolytic metastases appear as hyperintense to the background marrow on T2WI, whereas osteoblastic metastases appear as hypointense on both pulse sequences and may not enhance [4].
Multiple myeloma
Multiple myeloma (MM) is a malignant bone marrow neoplasm characterized by abnormal proliferation of monoclonal plasma cells. It usually disseminates throughout the axial skeleton, either multifocally or diffusely, and rarely does it present as a solitary lesion termed a plasmacytoma. The presenting symptom is usually bone pain [43].
Radiography is the primary diagnostic study for MM. Multifocal multiple myeloma, referred to as myelomatosis, results in a stippled pattern caused by multiple small, roundish osteolytic (“punched out”) lesions with sharp, non-sclerotic margins of uniform size (Fig. 10). They may coalesce into larger segments of osteolysis. CT can demonstrate a fuller extent of the disease and in some cases can show lesions not appreciated on radiography [44]. The signal intensities on MRI are similar to those of metastases; however, signal intensity abnormalities are not always present in myelomatous nodules [45]. MM may less commonly manifest in the calvaria as diffuse skeletal osteopenia where myeloma cells are intimately admixed with the hematopoietic cells without well-defined lytic lesions. This form is difficult to detect with CT and is best appreciated with MRI [46]. In contrast to metastases, which invariably involve secondary bone formation in response to the bone destruction, MM evolves as a purely lytic lesion [47]. As such, barring a skeletal complication such as bone fracture, it will not be detected with technetium 99-m based bone scans.
Squamous and basal cell carcinomas
Primary skin cancers of the scalp can secondarily invade the calvaria. These tumors predominate in men. A significant proportion of these tumors exhibit this tendency, partly because the subgaleal plane offers little resistance [48]. CT may show extremely ill defined osteolysis that begins at the outer table and can extend to the dura (Fig. 11) [49]. The solitary lesion shows the same intensities as metastasis on MRI. Occasionally, a calvarial metastasis that invades the skin secondarily can mimic a primary carcinoma of the scalp. All of the skin carcinomas in our series showed more extracranial involvement than intracranial involvement, a feature that can be helpful in distinguishing these tumors from metastasis.
Osteosarcoma
Osteosarcomas include a family of malignant neoplasms in which the malignant cells have the capacity to produce immature bone. These tumors rarely affect the skull vault and usually present in adolescents and young adults. When they arise in the calvaria later in life, they usually develop in the setting of pre-existing benign disease, such as Paget’s disease or less commonly fibrous dysplasia, or previous radiation [50]. Only two calvarial osteosarcomas have presented at the MNI since 1970: one was osteoblastic and of primary origin (Fig. 12) and the other was secondary to Paget’s disease.
As in the more commonly affected long bones, the osteosarcoma of the skull vault can be a lytic, blastic, or mixed-type [51]. Moreover, it usually presents with a wide zone of transition. CT helps identify the malignant nature of the lesion, shows the presence of new bone formation in the soft tissue component, and allows for accurate evaluation of intracranial extension [50]. MRI does not effectively show tumor calcification but can show soft-tissue involvement more clearly [52]. The lesion has low signal intensity on T1WI and a heterogeneous intensity on T2WI that depends on the matrix. For example, osteoblastic osteosarcoma has a relatively low signal appearance [53]. They enhance heterogeneously after contrast administration [21].
Paget’s disease and Paget’s sarcoma
Paget’s disease, also known as osteitis deformans, is an incompletely understood, albeit most likely genetically based condition that entails abnormal and excessive bone remodeling [54]. It is typically discovered incidentally and affects 3% of the population over 40 years of age. When the skull is involved, as it is in about half the cases, the entire thickness of the bone is affected. The disease progresses through three phases: an osteolytic phase, followed by a mixed phase characterized by the development of cortical and trabecular coarsening and thickening, and finally followed by a blastic phase characterized by marked bone sclerosis and thickening of the skull (Fig. 13) [55]. During the osteolytic phase, a lucent rim often surrounds the lesion on CT [56]. The MRI appearance varies with the stage of the disease. On both T1 and T2WI, the mixed phase is heterogeneously hyperintense due to the repopulation of intratrabecular spaces by fat cells whereas the blastic phase is hypointense as bone replaces these fat cells [55].
Sarcomatous transformation of Paget’s disease is a rare complication that has not presented at the MNI since the 1970s. The incidence of Pagetic sarcoma, which is most often an osteosarcoma, has declined to about 0.3% of patients [57]. It usually presents later in the course of the disease. Relative to most other Pagetic bones, the Pagetic skull rarely develops a sarcomatous neoplasm [58]. Interestingly, over half of the reported cases of benign giant-cell tumors associated with Paget’s disease have been observed in patients whose ancestry traces to Campania, Italy. They preferentially involve the skull [59]. We have not encountered such a case.
Conclusions
Arriving at a definitive diagnosis for calvarial lesions based solely on imaging can be tricky. Nonetheless, radiographic, CT, and MRI imaging studies and evaluation of the adult patient’s clinical history can help narrow the differential diagnosis.
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Acknowledgements
JG was supported by a McGill University Faculty of Medicine summer studentship.
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The authors declare that they have no conflicts of interest.
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Garfinkle, J., Melançon, D., Cortes, M. et al. Imaging pattern of calvarial lesions in adults. Skeletal Radiol 40, 1261–1273 (2011). https://doi.org/10.1007/s00256-010-0971-8
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DOI: https://doi.org/10.1007/s00256-010-0971-8