Abstract.
The H2-D and -Q regions of the mouse major histocompatibility complex (Mhc or H2) have been sequenced from strain 129/SvJ (haplotype bc), revealing a D/Q region different from all other investigated haplotypes, including the closely related b haplotype. The 300-kb class I-rich region consists of the classical class I, H2-D, and 11 non-classical class I genes. The Q region was formed by two series of tandem duplications. Comparison of the segment between the D and Q1 genes with the H2-K region provides evidence that class I genes were translocated from the K region to the D region, and gives a new explanation for the weak locus specificity of the H-K and H2-D alleles.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Author information
Authors and Affiliations
Additional information
Electronic Publication
Rights and permissions
About this article
Cite this article
Kumánovics, A., Madan, A., Qin, S. et al. Quod erat faciendum: sequence analysis of the H2-D and H2-Q regions of 129/SvJ mice. Immunogenetics 54, 479–489 (2002). https://doi.org/10.1007/s00251-002-0494-0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s00251-002-0494-0