Abstract
Background. Only ten cases of the rare occurrence of a malignant peripheral nerve-sheath tumor (MPNST) arising in a ganglioneuroma either de novo or at a site of previous irradiation have been reported.
Patients and methods. We present two children who at the age of 19 months and 6 months were diagnosed with a cervicothoracic ganglioneuroblastoma and a retroperitoneal neuroblastoma, respectively. They both received radiation therapy as part of the treatment of their disease.
Results. Following a 12-year interval, MPNST arose inside a benign ganglioneuroma in both patients. We illustrate the imaging findings in these two cases and review the cases reported in the literature to increase awareness of this association among radiologists.
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Received: 4 May 1999/Accepted: 7 September 1999
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Navarro, O., Nunez-Santos, E., Daneman, A. et al. Malignant peripheral nerve-sheath tumor arising in a previously irradiated neuroblastoma: report of 2 cases and a review of the literature. Pediatric Radiology 30, 176–180 (2000). https://doi.org/10.1007/s002470050040
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DOI: https://doi.org/10.1007/s002470050040