Abstract.
Preventive effects by traditional Chinese (Kampo) medicines, Unkei-to, Hachimi-jio-gan, and Juzen-taiho-to, on the progress of bone loss induced by ovariectomy in rats were investigated for a period of 49 days. The bone mineral density (BMD) of tibia in ovariectomized (OVX) rats decreased by 20% from those in sham-operated (Sham) rats, with the decrease completely inhibited by the administration of any one of these Kampo medicines or 17β-estradiol. From scanning electron microscopic (SEM) analyses, the surface of a trabecular bone of tibia in OVX rats had a porous or erosive appearance, whereas that of the same bone in Sham rats was composed of fine particles. The administration of three Kampo medicines and 17β-estradiol to OVX rats preserved the fine particle surface of the trabecular bone. These results strongly suggest that any of these three gynecological Kampo medicines is as effective as 17β-estradiol in preventing the development of bone loss induced by ovariectomy in rats.
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Received: 18 December 1995 / Accepted: 24 September 1996
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Hidaka, S., Okamoto, Y., Nakajima, K. et al. Preventive Effects of Traditional Chinese (Kampo) Medicines on Experimental Osteoporosis Induced by Ovariectomy in Rats . Calcif Tissue Int 61 , 239 –246 (1997). https://doi.org/10.1007/s002239900329
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DOI: https://doi.org/10.1007/s002239900329