Abstract.
Recently we found that the carboxyl-terminal propeptide of type I collagen (c-propeptide) is a major secretory protein of osteoblasts. Mature osteoblasts secreted 64 nM c-propeptide, and it was reported that 40 nM c-propeptide inhibited collagen synthesis at 80% of the control level. In this study, we investigated the effect of c-propeptide on collagen synthesis of preosteoblasts and osteoblasts, and found that preosteoblasts downregulated collagen synthesis by 40 nM c-propeptide, but osteoblasts were not affected by the same condition. When the binding activities of c-propeptide for preosteoblasts and osteoblasts were compared, osteoblasts showed weak affinity to c-propeptide compared with preosteoblasts, and the number of receptors for c-propeptide decreased in osteoblasts. These results imply that a decrease of receptors in osteoblasts might reduce the sensitivity of osteoblasts to c-propeptide.
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Received: 6 August 1999 / Accepted: 9 May 2000 / Online publication: 22 September 2000
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Mizuno, M., Fujisawa, R. & Kuboki, Y. The Effect of Carboxyl-Terminal Propeptide of Type I Collagen (c-Propeptide) on Collagen Synthesis of Preosteoblasts and Osteoblasts. Calcif Tissue Int 67, 391–399 (2000). https://doi.org/10.1007/s002230001150
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DOI: https://doi.org/10.1007/s002230001150