Abstract
Resolution of the enantiomers of (±)-econazole, (±)-miconazole, and (±)-sulconazole has been achieved on different normal-phase chiral amylose columns, Chiralpak AD, AS, and AR. The mobile phase used was hexane–2-propanol–diethylamine, 400:99:1 (v/v). The flow rates of the mobile phase used were 0.50 and 1.00 mL min–1. The α values for the resolved enantiomers of econazole, miconazole, and sulconazole on the chiral phases were in the range 1.63 to 1.04; the Rs values varied from 5.68 to 0.32.
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Received: 3 February 2001 / Revised: 2 April 2001 / Accepted: 10 April 2001
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Aboul-Enein, H., Ali, I. Comparison of the chiral resolution of econazole, miconazole, and sulconazole by HPLC using normal-phase amylose CSPs. Fresenius J Anal Chem 370, 951–955 (2001). https://doi.org/10.1007/s002160100884
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DOI: https://doi.org/10.1007/s002160100884