Abstract.
A simple, rapid and sensitive chemiluminescence (CL) method was proposed for the determination of lomefloxacin (LFX). This method is based on the fact that the weak CL from the redox reaction of Ce4+-Na2SO3 can be greatly enhanced by the complex of Tb3+-LFX. The CL intensity is directly proportional to the concentration of LFX in the range 2.0×10–9 to 1.0×10–5 mol L–1, and the detection limit (S/N=3) is 1.1×10–9 mol L–1. This method has been applied to the detection of LFX in pharmaceutical preparation, urine and serum samples. Recoveries were in the range 95–105%. The CL mechanism of Ce4+-Na2SO3-Tb3+-LFX system was proposed to be an intermolecular energy transfer from excited SO2 * to LFX and an intramolecular energy transfer from LFX to Tb3+.
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Nie, LH., Zhao, HC., Wang, X. et al. Determination of lomefloxacin by terbium sensitized chemiluminescence method. Anal Bioanal Chem 374, 1187–1190 (2002). https://doi.org/10.1007/s00216-002-1553-y
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DOI: https://doi.org/10.1007/s00216-002-1553-y