Avoid common mistakes on your manuscript.
In patients with cardiac arrest (CA) cerebral oximetry has emerged as a real-time indicator of oxygen delivery to the brain which could be used to optimise cerebral oxygenation during and after cardiopulmonary resuscitation (CPR) (Table 1). Near-infrared spectroscopy (NIRS) emits infrared light (700–950 nm wavelength), which is not absorbed significantly by melanin in the skin and enables non-invasive monitoring of the regional haemoglobin oxygen saturation in the brain (rSO2). NIRS electrodes are placed on the scalp above the frontal cortex and the sampling volume is located about 2 cm underneath the skull [1]. Since about 70% of the sampled blood is venous, normal rSO2 is approximately 60–80%. Unlike arterial pulse oximetry, rSO2 can still be measured when blood flow is nonpulsatile or even absent, enabling NIRS to be used during CA. Unlike the electroencephalogram, NIRS is not susceptible to motion artefact generated by CPR.
Use of cerebral oximetry during cardiac arrest
Higher rSO2 values during CPR are associated with significantly higher rates of return of spontaneous circulation (ROSC). In a review of 26 observational studies (1995–2016), the averaged mean rSO2 in patients achieving ROSC was 41 ± 12% vs. 30 ± 12% for those without ROSC (p = 0.009) [2]. However, there was wide overlap of rSO2 values between the two groups. Among 183 in-hospital CA (IHCA) patients [3], a 25% rSO2 cut-off predicted no ROSC with 100 [94–100]% specificity, while a 65% rSO2 cut-off predicted ROSC with 99 [95–100]% specificity. However, these values corresponded to the extremes of the distribution, so that the relevant sensitivities were low (13 [8–21]% and 21 [12–33]%, respectively).
During CPR, rSO2 trends appear to be better predictors of ROSC than mean values or values recorded at single time points. In a study on 329 out-of-hospital CA (OHCA) [4] rSO2 increased steadily during resuscitation in both ROSC and non-ROSC patients, but the increase was twice as high in the ROSC group [median 17% (IQR 6–29) vs. 8% (IQR 2–13); p < 0.001]. After adjustment for major confounders, a greater than 15% increase in rSO2 during CPR was the best predictor of ROSC (odds ratio [OR] 4.88 [2.79–8.54]).
As has been observed for end-tidal carbon dioxide (ETCO2), an abrupt increase in rSO2 values during CPR indicates that ROSC has occurred [5]. In a study on 53 OHCA patients, 22 (42%) had ROSC after a mean of 22.5 min of CPR; when ROSC occurred, the median rSO2 increased from 22.5% [16–35] to 51% [39–55] in 3 min [6]. A potential advantage of rSO2 compared with ETCO2 for monitoring during CPR is that detection of the rSO2 signal does not require advanced airway management.
In a study on IHCA [3], time with rSO2 > 50% during CPR best predicted favourable neurological outcome after resuscitation (cerebral performance category 1–2), suggesting that rSO2 may reflect the quality of cerebral oxygenation and perfusion during CPR. In another study, among 92 OHCA patients who arrived at the emergency department with ongoing CPR, the rate of neurological recovery was 50% in those with rSO2 > 40%, 22% in those with rSO2 26–40%, and 0% in those with rSO2 25% or less [7].
Cerebral oximetry in post-resuscitation care
Optimising cerebral oxygenation and perfusion is one of the mainstays of post-resuscitation care. Autoregulation of cerebral blood flow (CBF) is lost in about one third of comatose CA survivors [8], while in others the zone of autoregulation is narrowed and right-shifted [9] so that CBF is maintained consistent and independent from mean arterial pressure (MAP) only within a narrower and higher MAP range. In clinical studies the optimal MAP has been identified as that where the correlation coefficient between rSO2 and MAP (termed as COX) is minimal in the individual patient [9]. In children resuscitated from CA, deviations from optimal MAP have been associated with worse neurological outcome [8, 10]. In a study on 51 resuscitated comatose adults [9], the time spent below the optimal MAP was associated with a lower likelihood of survival (OR 0.97 [0.96–0.99], p = 0.02).
Cerebrovascular reactivity to CO2 is generally preserved after CA and manipulating arterial partial pressure of carbon dioxide (PaCO2) may be used in order to optimise CBF and brain oxygenation. In the recent COMACARE randomised pilot trial [11], a high-normal (5.8–6.0 kPa) PaCO2 was associated with higher rSO2 than low-normal (4.5–4.7 kPa) PaCO2 in comatose resuscitated patients. A larger randomised trial (NCT03114033) comparing mild hypercarbia (6.7–7.3 kPa) with normocarbia after CA is currently ongoing.
Current limitations and future perspectives
The association between higher rSO2 values during CPR and the rates of ROSC or neurological recovery suggests that rSO2 could be used as a physiological target to optimise CPR quality. However, the nature of this association is not completely clear. In fact, since NIRS signals can be contaminated from extracerebral circulation [12], rSO2 values during CPR may reflect whole-body rather than brain perfusion. In addition, patients who achieve ROSC usually show higher rSO2 values from the beginning of the resuscitation attempt [2], so that it is not clear whether a higher rSO2 in these patients reflects more effective CPR or, instead, other favourable factors, such as witnessed status or a shorter no-flow time.
Although lower nadir rSO2 levels have been associated with worse neurological outcome in resuscitated comatose patients [13], observational studies did not show an association between mean rSO2 in the early post-resuscitation phase and neurological outcome. In the COMACARE trial, changes in mean rSO2 were not associated with differences in the levels of neuron-specific enolase, a marker of neuronal ischaemia. However, rSO2 values were within normal values in all study groups. A limitation of this and other investigational models, such as the ones based on COX, is that the relationship between rSO2 and CBF is not well known, although a recent study has shown that rSO2 is positively correlated with cerebral perfusion pressure evaluated noninvasively using transcranial Doppler [14]. Further research is required to determine if cerebral oximetry is of real value in resuscitation, but based on current evidence it is not ready for routine clinical use.
References
Skhirtladze-Dworschak K, Dworschak M (2013) Cerebral oximetry and cardiac arrest. Semin Cardiothorac Vasc Anesth 17:269–275
Schnaubelt S, Sulzgruber P, Menger J, Skhirtladze-Dworschak K, Sterz F, Dworschak M (2018) Regional cerebral oxygen saturation during cardiopulmonary resuscitation as a predictor of return of spontaneous circulation and favourable neurological outcome—a review of the current literature. Resuscitation 125:39–47
Parnia S, Yang J, Nguyen R, Ahn A, Zhu J, Inigo-Santiago L, Nasir A, Golder K, Ravishankar S, Bartlett P, Xu J, Pogson D, Cooke S, Walker C, Spearpoint K, Kitson D, Melody T, Chilwan M, Schoenfeld E, Richman P, Mills B, Wichtendahl N, Nolan J, Singer A, Brett S, Perkins GD, Deakin CD (2016) Cerebral oximetry during cardiac arrest: a multicenter study of neurologic outcomes and survival. Crit Care Med 44:1663–1674
Genbrugge C, De Deyne C, Eertmans W, Anseeuw K, Voet D, Mertens I, Sabbe M, Stroobants J, Bruckers L, Mesotten D, Jans F, Boer W, Dens J (2018) Cerebral saturation in cardiac arrest patients measured with near-infrared technology during pre-hospital advanced life support. Results from Copernicus I cohort study. Resuscitation 129:107–113
Sandroni C, De Santis P, D'Arrigo S (2018) Capnography during cardiac arrest. Resuscitation 132:72–77
Prosen G, Strnad M, Doniger SJ, Markota A, Stozer A, Borovnik-Lesjak V, Mekis D (2018) Cerebral tissue oximetry levels during prehospital management of cardiac arrest—a prospective observational study. Resuscitation 129:141–145
Ito N, Nanto S, Nagao K, Hatanaka T, Nishiyama K, Kai T (2012) Regional cerebral oxygen saturation on hospital arrival is a potential novel predictor of neurological outcomes at hospital discharge in patients with out-of-hospital cardiac arrest. Resuscitation 83:46–50
Sekhon MS, Griesdale DE (2017) Individualized perfusion targets in hypoxic ischemic brain injury after cardiac arrest. Crit Care 21:259
Ameloot K, Genbrugge C, Meex I, Jans F, Boer W, Vander Laenen M, Ferdinande B, Mullens W, Dupont M, Dens J, DeDeyne C (2015) An observational near-infrared spectroscopy study on cerebral autoregulation in post-cardiac arrest patients: time to drop 'one-size-fits-all' hemodynamic targets? Resuscitation 90:121–126
Lee JK, Brady KM, Chung SE, Jennings JM, Whitaker EE, Aganga D, Easley RB, Heitmiller K, Jamrogowicz JL, Larson AC, Lee JH, Jordan LC, Hogue CW, Lehmann CU, Bembea MM, Hunt EA, Koehler RC, Shaffner DH (2014) A pilot study of cerebrovascular reactivity autoregulation after pediatric cardiac arrest. Resuscitation 85:1387–1393
Jakkula P, Reinikainen M, Hastbacka J, Loisa P, Tiainen M, Pettila V, Toppila J, Lahde M, Backlund M, Okkonen M, Bendel S, Birkelund T, Pulkkinen A, Heinonen J, Tikka T, Skrifvars MB, COMACARE study group (2018) Targeting two different levels of both arterial carbon dioxide and arterial oxygen after cardiac arrest and resuscitation: a randomised pilot trial. Intensive Care Med 44:2112–2121
Caccioppola A, Carbonara M, Macri M, Longhi L, Magnoni S, Ortolano F, Triulzi F, Zanier ER, Zoerle T, Stocchetti N (2018) Ultrasound-tagged near-infrared spectroscopy does not disclose absent cerebral circulation in brain-dead adults. Br J Anaesth 121:588–594
Bougle A, Daviaud F, Bougouin W, Rodrigues A, Geri G, Morichau-Beauchant T, Lamhaut L, Dumas F, Cariou A (2016) Determinants and significance of cerebral oximetry after cardiac arrest: a prospective cohort study. Resuscitation 99:1–6
Taccone FS, Crippa IA, Creteur J, Rasulo F (2018) Estimated cerebral perfusion pressure among post-cardiac arrest survivors. Intensive Care Med 44:966–967
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflicts of interest
Sandroni: none to declare. Parnia: none to declare. Nolan: Editor-in-Chief of Resuscitation.
Ethical approval
An approval by an ethics committee was not applicable.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Sandroni, C., Parnia, S. & Nolan, J.P. Cerebral oximetry in cardiac arrest: a potential role but with limitations. Intensive Care Med 45, 904–906 (2019). https://doi.org/10.1007/s00134-019-05572-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00134-019-05572-7