Article PDF
Avoid common mistakes on your manuscript.
Quellenverzeichnis
Wadey BL (2003) An innovative plasticizer for sensitive applications. J Vinyl Addit Techn 9(4):172–176. http://onlinelibrary.wiley.com/doi/10.1002/vnl.10080/abstract
BASF (2012) Hexamoll® DINCH® – der zuverlässige Nicht-Phthalatweichmacher. http://www.weichmacher.basf.com/portal/5/de/dt.jsp?setCursor=1_222675&seite=einsatzgebiete_hexamoll_dinch, http://www.weichmacher.basf.com/portal/5/de/dt.jsp?setCursor=1_230801
Janssen PJCM, Bremmer HJ (National Institute for Public Health and the Environment RIVM, Centre for Substances and Integrated Risk Assessment (SIR)) (2009) Risk assessment non-phthalate plasticizers in toys.1–27. https://www.vwa.nl/txmpub/files/?p_file_id=2000547
Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR) (2008) Opinion on the safety of medical devices containing DEHP-plasticized PVC or other plasticizers on neonates and other groups possibly at risk. http://ec.europa.eu/health/archive/ph_risk/committees/04_scenihr/docs/scenihr_o_014.pdf
Europäisches Parlament und Rat (2004) Verordnung (EG) Nr. 1935/2004 über Materialien und Gegenstände, die dazu bestimmt sind, mit Lebensmitteln in Berührung zu kommen 27. Oktober 2004 und zur Aufhebung der Richtlinien 80/590/EWG und 89/109/EWG. http://europa.eu/legislation_summaries/consumers/product_labelling_and_packaging/l21082a_de.htm
EU VERORDNUNG (EU) (2011) Nr. 10/2011 DER KOMMISSION vom 14. Januar 2011 über Materialien und Gegenstände aus Kunststoff, die dazu bestimmt sind, mit Lebensmitteln in Berührung zu kommen. Amtsblatt der Europäischen Union L 12/1–89. http://eur-lex.europa.eu/legal-content/EN/TXT/?qid=1400498090801&uri=CELEX:32011R0010
Badina J (2008) Base chemicals. Intermediates. BASF reinforces its presence in China [Chimie de base. Intermédiaires. BASF renforce sa présence en Chine] Info Chimie Magazine 45(484):20
Nagorka R, Conrad A, Scheller C, Süßenbach B, Moriske HJ (2011) Weichmacher und Flammschutzmittel im Hausstaub. Teil 2. Gefahrstoffe – Reinh. Luft 71(6): 286–292. http://www.gefahrstoffe.de/gest/article.php?data[article_id]=61206
BASF Pressemitteilung P-14-231 (2014) BASF verdoppelt Produktionskapazität für Hexamoll® DINCH® auf 200.000 Jahrestonnen. http://basf.com/group/pressemitteilung/P-14-231
BASF (2011) Technisches Merkblatt, Hexamoll® DINCH®, M 6168 d, Juni 2011 Ludwigshafen. http://www.weichmacher.basf.com/portal/5/de/dt.jsp?setCursor=1_222592
BASF (2000) Physico-chemical properties of 1,2-Cyclohexane dicarboxylic acid, di(isononyl)ester. Analytical report 99L00403. Ludwigshafen*
BASF (1999) Physico-chemical properties of 1,2-Cyclohexane dicarboxylic acid, di(isononyl)ester. Analytical report: 99L00403. ZAX Analytik BASF, Ludwigshafen
Bhaskaran Nair CS, Vidya R, Ashalatha PM (2011) Hexamoll DINCH plasticised PVC containers for the storage of platelets. Asian J Transfus Sci 5(1):18–22. http://dx.doi.org/10.4103%2F0973-6247.75972
Nussbaumer W, Schennach H, Mayersbach P, Nussbaumer O, Amann E, Herman M, Mayer W (2010) Suitability of a New Phthalate Free Plasticizer (Di-Isononyl-Cyclohexan-1,2-Dicarboxylat; Dinch) for Blood Bags. Vox sanguinis 99: Issue supplement S1, 116, P-0311, The XXXIst International Congress of the ISBT is organised in joint cooperation with the 43rd Congress of the DGTI Berlin, Germany, June 26–July 1. www.isbtweb.org/uploads/tx_isbtarchive/pdfs/2010_Berlin.pdf
IVLV (2011) Merkblätter für die Prüfung von Packmitteln, Merkblatt No. 107/2011: Leitfaden zur Bewertung von Phthalaten in Lebensmittelkontaktmaterialien. Industrievereinigung für Lebensmitteltechnologie und Verpackung e. V. (IVLV), herausgegeben von dem IVLV Arbeitskreis „Bewertung von Bedarfsgegenständen“ der Arbeitsgruppe „Qualität und Sicherheit verpackter Lebensmittel – QSVL“ – V1, Sept. 2011
EFSA (2006) Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request related to a 12th list of substances for food contact materials. EFSA J 395–401, 1–21. http://www.pvch.ch/docs/PDF/Hexamoll_DINCH_afc_op_ej_12thlist_op_en.pdf
Bopp K, Kuch B, Roth M (2010) Hormonelle Aktivität in natürlichen Mineralwässern? Deutsche Lebensmittel-Rundschau 106:489–500
Schossler P, Schripp T, Salthammer T, Bahadir M (2011) Beyond phthalates: gas phase concentrations and modeled gas/particle distribution of modern plasticizers. Sci Total Environ 409(19):4031–4038. http://www.sciencedirect.com/science/article/pii/S0048969711006334
National Industrial Chemicals Notification and Assessment Scheme (NICNAS) (2008) 1,2-Cyclohexanedicarboxylic acid, 1,2-diisononyl ester (‚Hexamoll DINCH‘) Full Public Report: STD/1259. http://www.nicnas.gov.au/publications/car/new/std/stdfullr/std1000fr/std1259fr.pdf
Bhat VS, Durham JL, Ball GL, English JC (2014) Derivation of an oral reference dose (RfD) for the nonphthalate alternative plasticizer 1,2-cyclohexane dicarboxylic acid, di-isononyl ester (DINCH). J Toxicol Environ Health B Crit Rev 17(2):63–94
Bundesinstitut für Risikobewertung (BfR) (2004) Bekanntmachung des Bundesinstituts für Risikobewertung: Gesundheitliche Beurteilung von Kunststoffen im Rahmen des Lebensmittel- und Bedarfsgegenständegesetzes. 207. Mitteilung. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 47(6):602–604. http://springerlink.bibliotecabuap.elogim.com/article/10.1007/s00103-004-0850-3
Bundesinstituts für Risikobewertung (BfR) (2011) BfR bewertet Untersuchungen zu hormonähnlichen Wirkungen von in natürlichen Mineralwässern vorkommenden Substanzen. Stellungnahme Nr. 007/2011 des BfR vom 2. Feb. 2011, Berlin. http://www.bfr.bund.de/cm/343/bfr_bewertet_untersuchungen_zu_hormonaehnlichen_wirkungen_von_in_natuerlichen_mineralwaessern_vorkommenden_substanzen.pdf
OECD (Organisation for Economic Cooperation and Development) OECD GUIDELINE FOR THE TESTING OF CHEMICALS Test No. 417 Toxicokinetics. 23 July 2010. http://www.oecd-ilibrary.org/environment/test-no-417-toxicokinetics_9789264070882-en
BASF (2003) 14C-1,2-Cyclohexanedicarboxylic acid, diisononyl ester – study of the biokinetics in rats. Project no.: 02B0608/016021. Ludwigshafen*
BASF (2005) 14C-1,2-Cyclohexanedicarboxylic acid, diisononyl ester – Study of the Biokinetics in Rats. Amendment No. 1 to the Report. Project No.: 02B0608/016021. Ludwigshafen*
BASF (2005) Investigations on the metabolism of 14C-1,2-Cyclohexane dicarboxylic acid diisononyl ester (DINCH) in rats. Project No.: 197662. Ludwigshafen*
Silva M, Calafat A, Furr J, Gray E, Preau J, Samandar E (2011) Biomarkers of Di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH). Abstract Number: 2010–3, PITTCON 2011, March 13–18, Atlanta. http://ca.pittcon.org/technical+program/tpabstra11.nsf/Agenda+Time
Silva MJ, Furr J, Preau J, Samandar E, Gray E, Calafat A (2012) Identification of potential biomarkers of exposure to di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH), an alternative for phthalate plasticizers. J Expo Sci Environ Epidemiol 22(2):204–211. http://www.nature.com/jes/journal/v22/n2/full/jes201143a.html
Koch HM, Schütze A, Pälmke C, Angerer J, Brüning T (2013) Metabolism of the plasticizer and phthalate substitute diisononyl-cyclohexane-1,2-dicarboxylate (DINCH(®)) in humans after single oral doses. Arch Toxicol 87(5):799–806. doi:10.1007/s00204-012-0990-4
BASF (1999) 1,2-Cyclohexane dicarboxylic acid, di(isononyl)ester, acute oral toxicity in rats. Project no.:10A0223/991059. Ludwigshafen
BASF (1999) 1,2-Cyclohexane dicarboxylic acid, di(isononyl)ester, acute dermal toxicity in rats. Project no.:11A0223/991060. Ludwigshafen*
BASF (2004) Hexamoll* DINCH – Acute dermal irritation/ corrosion in rabbits. Project No.: 18H0010/042033. Ludwigshafen*
BASF (1999) 1,2-Cyclohexane dicarboxylic acid, di(isononyl)ester – acute eye irritation in rabbits. Project No.: 11H0223/992126. Ludwigshafen
BASF (1999) 1,2-Cyclohexane dicarboxylic acid, di(isononyl)ester -maximization test in guinea pigs. Project no.: 30H0223/992127. Ludwigshafen*
BASF (2000) 1,2-Cyclohexane dicarboxylic acid, di(isononyl) ester. Repeated dose oral toxicity study in Wistar rats. Administration in the diet for 4 weeks and recovery period of 2 weeks. Project no.: 37S0223/99062. Ludwigshafen*
BASF (2002) 1,2 Cyclohexane dicarboxylic acid, di(isononyl)ester – Subchronic oral toxicity study in Wistar rats. Administration in the diet for 3 months. Project No.: 50S0107/01009. Ludwigshafen*
BASF (2005) 1,2-Cyclohexane dicarboxylic acid, di(isononyl) ester. Liver enzyme induction study in Wistar rats. Administration in the diet over 2 weeks. Project No.: 48C0107/01181. Ludwigshafen*
BASF (2005) 1,2-Cyclohexane dicarboxylic acid, di(isononyl) ester. Thyroid function study in male Wistar rats using perchlorate discharge as a diagnostic test. Administration in the diet over 4 weeks. Project no.: 48C0107/01180. Ludwigshafen*
Boas M, Feldt-Rasmussen U, Skakkebæk NE, Main KM (2006) Environmental chemicals and thyroid function. Eur J Endocrinol 154(5):599–611. http://eje-online.org/content/154/5/599.long
Capen CC (1997) Mechanistic data and risk assessment of selected toxic end points of the thyroid gland. Toxicol Pathol 25(1):39–48. http://tpx.sagepub.com/content/25/1/39.full.pdf
Klaassen CD, Hood AM (2001) Effects of microsomal enzyme inducers on thyroid follicular cell proliferation and thyroid hormone metabolism. Toxicol Pathol 29(1):34–40. http://tpx.sagepub.com/content/29/1/34.full.pdf
Kronenberg HM, Melmed S, Polonsky KS, Larsen PR (2007) Williams textbook of endocrinology, 11th revised edition, Saunders,1936 p. ISBN: 978-1-4160-2911-3. http://www.us.elsevierhealth.com/category/williams-textbook-of-endocrinology-expert-consult/9781416029113/
International Agency for Research on Cancer (IARC) (1999) Species differences in thyroid, kidney and urinary bladder carcinogenesis. In: Capen CC, Dybing E, Rice JM & Wilbourn JD (Hrsg) IARC Sci. Pub. no. 147, ISBN 92 832 2147 8. http://monographs.iarc.fr/ENG/Publications/index0.php
Haschek WM, Rousseaux CG, Wallig MA (2010) Endocrine system (Chap. 17). In: Fundamentals of toxicologic pathology (2nd ed). Academic Press, San Diego, 2010, 513–551. ISBN: 978-0-12-370469-6. http://www.sciencedirect.com/science/article/pii/B9780123704696000179
BASF (2005) 1,2 Cyclohexane dicarboxylic acid, di(isononyl) ester. S-Phase response study in the liver of Wistar rats. Administration in the diet for 1, 4 and 13 weeks. Project no.: 99S0107/01082. Ludwigshafen*
BASF (2000) Salmonella typhimurium/Escherichia coli reverse mutation assay (standard plate test and preincubation test) with 1,2-Cyclohexane dicarboxylic acid, di (isononyl)ester. Project no.: 40MO223/994088. Ludwigshafen*
BASF (2000d) In vitro Chromosome Aberration Assay in Chinese Hamster V79 Cells with 1,2-Cyclohexane dicarboxylic acid, di(isononyl)ester. RCC-CCR Project no. 651400. BASF Project no.: 32MO223/999040. Roßdorf*
BASF (2001) In vitro gene mutation test with 1,2 Cyclohexane dicarboxylic acid, di(isononyl)ester in CHO cells (HPRT Locus assay). Project no.: 50MO107/014031. Ludwigshafen*
BASF (2001) Micronucleus assay in bone marrow cells of the mouse with cyclohexane dicarboxylic acid, di(isononyl)ester. Study conducted by RCC Cytotest Cell Research. Sponsored by BASF AG, Ludwigshafen, Germany*
BASF (2005) 1,2-Cyclohexane dicarboxylic acid, di(isononyl) ester – Combined Chronic Toxicity/ Carcinogenicity study in CrlGlxBrlHan:WI-rats; Administration in the diet up to 24 months. Project no.: 82S0107/01094. Ludwigshafen*
BASF (2003) 1,2-Cyclohexane dicarboxylic acid, di(isononyl) ester. Two-generation reproduction toxicity study in Wistar rats. Continuous dietary administration. Project no.: 70 R01 07/01021. Ludwigshafen*
BASF (2002) 1,2-Cyclohexane dicarboxylic acid, di(isononyl) ester. Prenatal developmental toxicity study in Wistar rats. Oral administration (Gavage). Project no.: 30 R0223/99124. Ludwigshafen*
BASF (2004) 1,2-CYCLOHEXANE DICARBOXYLIC ACID, DI(ISONONYL)ESTER – Prenatal developmental toxicity study in Himalayan rabbits. Administration in the diet Project no.: 42R0107/01135. Ludwigshafen*
BASF (2002) 1,2-Cyclohexane dicarboxylic acid, di(isononyl) ester. Pre-/postnatal developmental toxicity study in Wistar rats. Oral administration (gavage). Project no.: 60R0223/99095. Ludwigshafen*
Furr JR, Lambright CS, Wilson VS, Foster PM, Gray LE Jr (2014) A short-term in vivo screen using fetal testosterone production, a key event in the phthalate adverse outcome pathway, to predict disruption of sexual differentiation. Toxicol Sci 140(2):403–424. doi:10.1093/toxsci/kfu081. http://toxsci.oxfordjournals.org/content/140/2/403.abstract
Hannas BR, Lambright CS, Furr J, Howdeshell KL, Wilson VS, Gray LE (2011) Dose-response assessment of fetal testosterone production and gene expression levels in rat testes following in utero exposure to diethylhexyl phthalate, diisobutyl phthalate, diisoheptyl phthalate, and diisononyl phthalate. Toxicol Sci 123(1):206–216. http://toxsci.oxfordjournals.org/content/123/1/206.abstract
Gray LE (2011) Additive effects of compounds with different modes of action: effects of mixtures of phthalates and other toxicants on sexual differentiation in rats: a risk assessment framework based upon disruption of common developing systems. Environmental health decision meeting: mixtures and cumulative risk assessment: new approaches using the latest science and thinking about pathways, July 27–28, 2011, Conference Center Washington, DC. http://nas-sites.org/emergingscience/files/2011/06/Mixtures_July2011_agenda3.pdf; http://nas-sites.org/emergingscience/files/2011/08/Gray.pdf; http://nas-sites.org/emergingscience/meetings/mixtures/
U.S. Environmental Protection Agency (1998) Assessment of thyroid follicular cell tumors. U.S. Environmental Protection Agency, Washington, DC, EPA/630/R-97/002
CPSC (2010) Review of exposure and toxicity data of phthalate substitutes. Bethesda. http://www.cpsc.gov/about/cpsia/phthalsub.pdf, http://www.cpsc.gov/PageFiles/126546/phthalsub.pdf
Schütze A, Pälmke C, Angerer J, Weiss T, Brüning T, Koch HM (2012) Quantification of biomarkers of environmental exposure to di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) in urine via HPLC– MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci 895–896:123–130. http://www.sciencedirect.com/science/article/pii/S1570023212001900
HBM Kommission (2007) Ableitung von Human-Biomonitoring-(HBM-)Werten auf der Basis tolerabler Aufnahmemengen –Teil II: Grundlagen und Ableitungsweg. Stellungnahme der Kommission Human-Biomonitoring des Umweltbundesamtes. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 50(2):251–254. http://springerlink.bibliotecabuap.elogim.com/article/10.1007%2Fs00103-007-0146-5
Schütze A, Kolossa-Gehring M, Apel P, Brüning T, Koch HM (2014) Entering markets and bodies: increasing levels of the novel plasticizer Hexamoll® DINCH® in 24 h urine samples from the German Environmental Specimen Bank. Int J Hyg Environ Health 217(2–3):421–426. doi:10.1016/j.ijheh.2013.08.004. http://www.sciencedirect.com/science/article/pii/S1438463913001168
Danksagung.
Die HBM-Kommission dankt Dr. Ulrich Wahnschaffe, Dr. Oliver Licht und Dr. Inge Mangelsdorf (Hannover) für die Erstellung des Textentwurfes,Dr. Rainer Otter (Ludwigshafen), Petra Apel (Berlin), Dr. Holger M. Koch (Bochum) und Prof. Dr. Jürgen Angerer (Uttenreuth) für die ergänzenden Beiträgesowie Angela Lehmann (Berlin) für die Unterstützung bei der redaktionellen Bearbeitung.
Author information
Consortia
Ethics declarations
Interessenkonflikt
Es besteht kein Interessenkonflikt.
Rights and permissions
About this article
Cite this article
Bekanntmachung des Umweltbundesamtes. Stoffmonographie für 1,2-Cyclohexandicarbonsäure-di-isononylester (Hexamoll® DINCH®) – HBM-Werte für die Summe der Metabolite Cyclohexan-1,2-dicarbonsäure-mono-hydroxyisononylester (OH-MINCH) und Cyclohexan-1,2-dicarbonsäure-mono-carboxyisooctylester (cx-MINCH) im Urin von Erwachsenen und Kindern. Bundesgesundheitsbl. 57, 1451–1461 (2014). https://doi.org/10.1007/s00103-014-2069-2
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00103-014-2069-2