Abstract
Purpose:
To retrospectively report the outcome of head and neck cancer patients following re-irradiation.
Patients and Methods:
A total of 51 patients with recurrent or second primary head and neck cancer received re-irradiation at Leuven University Hospital. Survival and locoregional control were calculated. Doses to organs at risk were retrieved from dose–volume histograms. Radiation-related toxicities were reported.
Results:
The 2-year actuarial overall survival rate was 30%. On univariate analysis, surgery before re-irradiation and high radiation dose were associated with superior survival. Grade 3 acute and grade 3 or more late toxicity occurred in respectively 29.4% and 35.3% of the patients.
Conclusion:
Re-irradiation in head and neck cancer patients is feasible with acceptable late toxicity, although the survival remains poor.
Zusammenfassung
Ziel:
Retrospektive Auswertung von Patienten mit Kopf-Hals-Tumoren nach Re-Bestrahlung.
Patienten und Methodik:
51 Patienten mit rezidivierten oder sekundären primären Kopf-Hals-Tumoren erhielten eine Re- Bestrahlung an der Universitätsklinik Leuven (Löwen). Das Überleben und die lokoregionale Kontrolle wurden ermittelt. Die Dosen für die Risiko-Organe wurden den Dosis-Volumen-Histogrammen entnommen. Die mit Re-Bestrahlung verbundenen Toxizitäten wurden ausgewertet.
Ergebnisse:
Die 2-Jahres-Überlebensrate betrug 30% (Abbildung 2). In einer univariaten Analyse waren eine Operation vor der erneuten Bestrahlung und eine hohe Strahlendosis mit höheren Ûberlebensraten assoziiert (Tabelle 3). Akuttoxizität Grad 3 oder Spättoxizität Grad 3 und höher traten bei 29.4% bzw. 35.3% der Patienten auf.
Schlussfolgerung:
Eine Re-Bestrahlung bei Patienten mit Kopf-Hals-Tumoren ist durchführbar mit akzeptabler Spättoxizität; das Gesamt-Überleben ist gering.
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Platteaux, N., Dirix, P., Vanstraelen, B. et al. Outcome after Re-Irradiation of Head and Neck Cancer Patients. Strahlenther Onkol 187, 23–31 (2011). https://doi.org/10.1007/s00066-010-2139-9
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DOI: https://doi.org/10.1007/s00066-010-2139-9