Abstract.
Olfactory receptors typically exhibit poor plasma membrane localization and functionality when heterologously expressed in most cell types. It has therefore proven difficult to effectively study olfactory receptor pharmacology and signaling mechanisms using traditional cell culture systems. Over the past few years, a variety of distinct proteins have been reported to interact with olfactory receptors and facilitate olfactory receptor trafficking to the plasma membrane in heterologous cells. Advances in this area have shed significant light on the fundamental factors governing the cell-specific control of olfactory receptor trafficking.
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Received 16 January 2008; received after revision 19 February 2008; accepted 22 February 2008
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Bush, C.F., Hall, R.A. Olfactory receptor trafficking to the plasma membrane. Cell. Mol. Life Sci. 65, 2289–2295 (2008). https://doi.org/10.1007/s00018-008-8028-z
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DOI: https://doi.org/10.1007/s00018-008-8028-z