Abstract.
Telomeres were first recognized as a bona fide constituent of the chromosome based on their inability to rejoin with broken chromosome ends produced by radiation. Today, we recognize two essential and interrelated properties of telomeres. They circumvent the so-called end-replication problem faced by genomes composed of linear chromosomes, which erode from their termini with each successive cell division. Equally vital is the end-capping function that telomeres provide, which is necessary to deter chromosome ends from illicit recombination. This latter property is critical in facilitating the distinction between the naturally occurring DNA double-strand breaks (DSBs) found at chromosome ends (i.e., telomeres) and DSBs produced by exogenous agents. Here we discuss, in a brief historical narrative, key discoveries that led investigators to appreciate the unique properties of telomeres in protecting chromosome ends, and the consequences of telomere dysfunction, particularly as related to recombination involving radiation-induced DSBs.
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In appreciation of his heart-felt commitment to research and education, and the life-long influence he has had on the lives of students and colleagues, the authors wish to dedicate this paper to Professor Joel S. Bedford.
Received 21 May 2007; received after revision 28 June 2007; accepted 6 August 2007
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Bailey, S.M., Cornforth, M.N. Telomeres and DNA double-strand breaks: ever the twain shall meet?. Cell. Mol. Life Sci. 64, 2956–2964 (2007). https://doi.org/10.1007/s00018-007-7242-4
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DOI: https://doi.org/10.1007/s00018-007-7242-4