Abstract.
Objective and Design: The study was designed to elucidate whether cyclosporine A (Cy A) induces oxidative stress in heart, liver and kidney.¶Material and Treatment: Male Wistar rats were treated with NaCl (n = 7), cremophor (vehicle for Cy A; n = 7) and 30 mg/kg b.w. Cy A in cremophor (n = 7) daily for 4 weeks.¶Methods: Oxidized (GSSG) and reduced (GSH) glutathione, lipid peroxides and superoxide dismutase were measured in the organs.¶Results: Increases in GSSG [nmol/mg prot.] and a compensatory rise in total GSH [nmol/mg prot.] indicating Cy A-induced oxidative stress were found in kidney (0.39 ± 0.09 vs. 0.47 ± 0.14 vs. 0.64 ± 0.18; 20.71 ± 3.86 vs. 21.07 ± 3.86 vs. 28.14 ± 3.37) and liver (0.51 ± 0.11 vs. 0.51 ± 0.09 vs. 0.65 ± 0.25; 33.35 ± 5.06 vs. 32.88 ± 5.12 vs. 44.12 ± 6.06) but not in heart.¶Conclusion: Cy A-induced oxidative stress may contribute to the hepatotoxicity and nephrotoxicity of this drug. After heart transplantation, accelerated allograft atherosclerosis limits transplantation success. We did not find any evidence that Cy A induces oxidative stress in the heart which might favour atherogenesis.
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Received 11 March 1997; returned for revision 17 June 1997; returned for final revision 4 September 1997; accepted by E. Neugebauer 15 September 1997
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Haberland, A., Henke, W., Grune, T. et al. Differential response of oxygen radical metabolism in rat heart, liver and kidney to cyclosporine A treatment. Inflamm. res. 46, 452–454 (1997). https://doi.org/10.1007/s000110050223
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DOI: https://doi.org/10.1007/s000110050223