Abstract.
Objective and design:
To investigate the effect of experimental tumor bearing on acute inflammation models in rats.
Methods:
Four and 7 days after Walker tumor implantation in the right armpit, carrageenan or dextran– induced edema in the contralateral paw, carrageenan induced neutrophil migration into peritoneal cavities, cutaneous vascular permeability induced by bradykinin, histamine, serotonin, substance P, capsaicin or compound 48/80, and mesenteric mast cell degranulation induced by compound 48/80 were evaluated. The control group did not receive tumor implantation. Statistical analysis was performed using one way analysis of variance (ANOVA) followed by the Bonferroni test.
Results:
On the 7th day after tumor inoculation, there were significant decreases in both carrageenan and dextran- induced paw edema. Tumor bearing did not change the neutrophil infiltration induced by carrageenan. There were decreases in cutaneous vascular permeability induced by compound 48/80, serotonin or bradykinin, but not that induced by histamine, substance P. A significant inhibition of mesenteric mast cell degranulation induced by compound 48/80 was observed, on the 4th and 7th days after tumor inoculation.
Conclusion:
Tumor bearing can limit mast cell function and vascular events in acute systemic inflammation in rats, without changes in neutrophil migration.
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Received 20 July 2008; returned for revision 27 August 2008; received from final revision 4 November 2008; accepted by A. Falus 6 November 2008
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Barbosa, A.L.R., Pinheiro, C.A., Oliveira, G.J. et al. Tumor bearing decreases systemic acute inflammation in rats – role of mast cell degranulation. Inflamm. Res. 58, 235–240 (2009). https://doi.org/10.1007/s00011-008-8226-z
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DOI: https://doi.org/10.1007/s00011-008-8226-z