Abstract.
Objective
Cardiac mast cell numbers increase significantly within 12 h following the creation of an aortocaval (AV) fistula in rats and play a central role in mediating adverse left ventricular remodeling. We studied whether this increase was related to maturation of resident immature mast cells.
Methods
We measured percentages of immature and mature cardiac mast cells at 1, 2 and 7 days following AV-fistula or sham surgery and in non-surgical control rats using the alcian-blue safranin reaction.
Results
Relative to sham-operated and control rats, there was a significant shift from immature to a greater percentage of mature cardiac mast cells at 1 day and 2 days post-fistula that returned to a normal distribution by 7 days.
Conclusions
We conclude that the acute increase in mast cell density following volume overload is due to a paracrine response in the heart that stimulates the maturation and differentiation of resident immature cardiac mast cells.
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Received 10 June 2005; returned for revision 14 July 2005; accepted by A. Falus 29 March 2006
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Forman, M.F., Brower, G.L. & Janicki, J.S. Rat cardiac mast cell maturation and differentiation following acute ventricular volume overload. Inflamm. res. 55, 408–415 (2006). https://doi.org/10.1007/s00011-006-6016-z
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DOI: https://doi.org/10.1007/s00011-006-6016-z