Abstract.
Immunoregulatory T cells play a key role in modifying the immune responses to self antigens, tumor antigens, and pathogenic organisms. This review summarizes recent data on naturally occurring CD4+ regulatory T cells that constitutively express CD25 (CD25+Treg). We examine the markers that can be used to differentiate these cells from effector T cells, what is known about their mode of action in controlling the activity of effector T cells, the antigenic specificity of CD25+Treg, and their ability to survive and to be selected in vivo. We also summarize specific information on the role of CD25+Treg in controlling anti-tumor responses, an area were manipulation of this subset holds particular clinical promise.
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Abbreviations
- CD25+Treg:
-
CD4+CD25+Foxp3+ regulatory T cells
- TGF-β:
-
transforming growth factor β
- CTLA-4:
-
cytotoxic T lymphocyte antigen-4
- DC:
-
dendritic cell
- TCR:
-
T cell antigen receptor
- GITR:
-
glucocorticoid-induced tumor necrosis factor receptor family-related
- Rag:
-
recombinase activating gene
- NOD:
-
non-obese diabetic
- IBD:
-
inflammatory bowel disease
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Rudge, G., Gleeson, P.A. & van Driel, I.R. Control of immune responses by immunoregulatory T cells. Arch. Immunol. Ther. Exp. 54, 381–391 (2006). https://doi.org/10.1007/s00005-006-0045-8
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DOI: https://doi.org/10.1007/s00005-006-0045-8