Abstract
Extremozymes that function in the extreme environmental conditions of temperature, pressure, pH, and salinity are of great importance for industrial processes and scientific research. Apart from understanding the principle behind the stability of such enzymes, there has been considerable effort to isolate enzymes from extremophiles (organisms that live in extreme environmental conditions) as well as modify enzymes from mesophiles (organisms that live in normal environmental conditions) to convert them into extremozymes.
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Rainer J. Enzymes under extremes of physical conditions.Ann. Rev. Biophys. Bioeng. 10. pp. 1–67, 1981.
Shami E Y, Rotherstein A and Ramjee Singh M. Stabilization of biologically active proteins.Trends in Biotechnology. 7.pp. 186–190, 1989.
Faye F. The chemistry of life at the Margins.Science. 265. pp. 471–472, 1994.
Gokhale R S, Agarwalla S, Francis V S and Balaram P. Thermal stabilization of Thymidylate synthase by engineering disulfide bridges across the dimer interface.J. Mol. Biol. 235. pp. 89–94, 1994.
Dym O, Mevarech M and Sussman J L. Structural features that stabilize halophilic malate dehydrogenase from anarchaebacterium.Science. 267.pp. 1344–1346, 1995.
Ker R A. Life goes to extreme in the deep earth-and elsewhere.Science. 276. pp. 703–704, 1995.
Korolev S, Nayal M, Barnes W M, DiCera E and Waksman G. Crystal structure of the large fragment ofThermits aquaticus DNA polymerase 1 at 2.5 A° resolution: Structural basis for thermostability.Proc. Natl Acad. Sci. 92.pp. 9264–9268, 1995.
Madigan M T and Mans B L. Extremophiles.Sci. Am. pp. 66–71, 1997.
Pennisi E. In Industry, extremophiles begin to make their mark.Science. 226. pp. 705–706, 1997.
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Kumar, S. Enzyme vs. extremozyme. Reson 3, 32–40 (1998). https://doi.org/10.1007/BF02837612
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DOI: https://doi.org/10.1007/BF02837612