Abstract
To determine the psychophysiological correlates of hormonal response during sexual activity, systolic blood pressure (SBP), anal electromyography (EMG), and anal photoplethysmography (APG) were monitored continuously throughout testing in 13 women and 10 men. Each subject completed two or more tests of self-stimulation to 5 min beyond orgasm. Blood samples were obtained continuously for measurement of oxytocin (OT) levels. In both men and women, very high positive correlations were observed between the percentage change in levels from baseline through orgasm of: OT and SBP; OT and EMG intensity prior to and during orgasm; APG and EMG. The number of anal contractions and duration of orgasm were also highly correlated. Two patterns of orgasm were defined by the presence or absence of a quiescent period between orgasmic contractions. EMG and APG amplitudes correlated with the pattern of orgasm. Subjective orgasm intensity correlated significantly with increased levels of OT in multiorgasmic women only. The positive correlations between measures are consistent with a possible functional role for OT in human sexual response.
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Abramson, P. R., and Mosher, D. L. (1975). Development of a measure of negative attitudes toward masturbation.J. Consult. Clin. Psychol. 43: 485–490.
Altura, B. M., and Altura, B. T. (1984). Actions of vasopressin, oxytocin, and synthetic analogs on vascular smooth muscle.Fed. Proc. 43: 80–86.
Arletti, R., Benelli, A., and Bertolini, A. (1990). Sexual behavior of aging male rats is stimulated by oxytocin.Eur. J. Pharmacol. 179: 377–381
Beck, A. T., and Beamesderfer, A. (1974). Assessment of depression: The depression inventory. In Pichot, P. (ed.),Psychological Measurements in Psychopharmacology: Modern Problems in Pharmacopsychiatry, Vol. 7 Karger, Basel, pp. 151–169.
Bohlen, J. G., Held, J. P., and Sanderson, M. O. (1980). The male orgasm: Pelvic contractions measured by anal probe.Arch Sex. Behav. 9: 503–521.
Bohlen, J. G., Held, J. P., Sanderson, M. O., and Ahlgren, A. (1982). The female orgasm: Pelvic contractions.Arch. Sex. Behav. 11: 367–386.
Bohus, B. (1980). Effects of neuropeptides on adaptive autonomic processes. In deWied, D., and van Keep, P. A. (eds.),Hormones and the Brain MTP Press, Lancaster.
Caldwell, J. D. (1991, May). Central oxytocin and female sexual receptivity. Paper presented atOxytocin in Maternal, Sexual and Social Behaviors. N.Y.A.S., Arlington, VA.
Carmichael, M. S., Humbert, R., Dixen, J., Palmisano, G., Greenleaf, W., and Davidson, J.M. (1987). Plasma oxytocin increases in the human sexual response.J. Endocrinol. Metab. 64: 27–31.
Carter, C. S. (1992). Oxytocin and sexual behavior.Neurosci. Biobehav. Rev. 16: 131–144.
Davidson, J. M. (1980). The psychobiology of sexual experience. In Davidson, J. M., and Davidson, R. J. (eds.),Psychobiology of Consciousness Plenum Press, New York, pp. 271–332.
Fox, C. A. (1976). Some aspects and implications of coital physiology.J. Sex Marital Ther. 2: 205–213.
Fox, C. A., and Fox, B. (1969). Blood pressure and respiratory patterns during human coitus.J. Reprod. Fertil. 19: 405–415.
Fox, C. A,. and Fox, B.A. (1971). A comparative study of coital physiology with special reference to the sexual climax.J. Reprod. Fertil. 24: 319–336.
Gebhard, P. (1970). Factors in marital orgasm. In Shiloh, A. (ed.),Studies in Human Sexual Behavior: The American Scene Charles C. Thomas, Springfield, IL, pp. 267–274.
Gibson, A., Bern, H. A., Ginsburg, M., and Botting, J. H. (1984). Neuropeptide-induced contraction and relaxation of the mouse anococcygeus muscle.Proc. Natl. Acad. Sci. U.S. 81: 625–629.
Gillan, P., and Brindley, G. S. (1979). Vaginal and pelvic floor responses to sexual stimulation.Psychophysiology 16: 471–481.
Hathaway, S. R., and McKinley, J. C. (1943).Manual for the Minnesota Multiphasic Personality Inventory Psychological Corporation, New York.
Hib, J. (1974). The contractility of the cauda epididymis of the mouse, its spontaneous activity in vitro and the effects of oxytocin.J. Reprod. Fertil. 36: 191–193.
Kadefors, R., and Petersen, I. (1970). Spectral analysis of myo-electric signals from muscles of the pelvic floor during voluntary contraction and during reflex contractions connected with ejaculation.Electromyography 1: 45–68.
Kaplan, H. S. (1974).The New Sex Therapy Brunner/Mazel, New York.
Knight, T. W. (1972). In vivo effects of oxytocin on the contractile activity of the cannulated epididymis and vas deferens in rams.J. Reprod. Fertil. 28: 141.
Lapides, J., and Bobbitt, J. M. (1956). Diagnostic value of the bulbocavernosus reflex.J. Am. Med. Assoc. 162: 971–972.
Levin, R. J. (1981). The female orgasm—A current appraisal.J. Psychosom. Res. 25: 119–133.
Littler, W. A., Honour, A. J., and Sleight, P. (1974). Direct arterial pressure, heart rate and electrocardiogram during human coitus.J. Reprod. Fertil. 40: 321–331.
Masters, W. H., and Johnson, V. E. (1966).Human Sexual Response Little, Brown, Boston.
Melin, P. (1970). Effects in vivo of neurohypophysial hormones on the contractile activity of accessory sex organs in male rabbits.J. Reprod. Fertil. 22: 283–292.
Mishra, S. K., and Raviprakash, V. (1982). Alpha-thioglycerol sensitive excitatory oxytocin receptors in fowl rectum.Experientia 38: 136–137.
Montastruc, J. L., Tran, L. D., and Montastruc, P. (1983). Peptides neuro-hypophysaires et controle central cardiovasculaire.Arch. Mal. Coeur 76: 9–12.
Morris, M., and Keller, M. (1982). A specific deficiency in paraventricular vasopressin and oxytocin in the spontaneously hypertensive rat.Brain Res. 249: 173–176.
Murphy, M. R., Checkley, S. A., Seckl, J. R., Burton, S., and Lightman, S. L. (1990). Naloxone inhibits oxytocin release at orgasm in man.J. Clin. Endocrinol. Metab. 71: 1056–1058.
Murphy, M. R., Seckl, J. R., Burton, S., Checkley, S. A., and Lightman, S. L. (1987). Changes in oxytocin and vasopressin secretion during sexual activity in men.J. Clin. Endocrinol. Metab. 65: 738–741.
Newton, N. (1978). The role of the oxytocin reflexes in three interpersonal reproductive acts: Coitus, birth and breast feeding. In Carenza, L., Pancheri, P., and Zichella, L. (eds.),Clinical Psychoneuroendocrinology in Reproduction, Proceedings of the Serono Symposium, Vol. 22, Academic Press, London, pp. 411–418.
Ogawa, S., Kudo, S., Kitsunai, Y. and Fukuchi, S. (1980). Increase in oxytocin secretion at ejaculation in male.Clin. Endocrinol. 13: 95–97.
Peeters, G., and Houvenaghel, A. (1973). Reflex release of milk-ejection activity by stimulation of organs in the pelvic region in sheep as studied by cross-circulation experiments.J. Endocrinol. 58: 53–66.
Peeters, G., Legros, J. J., Piron-Bossuyt, C., Reynaert, R., Vanden Driessche, R., and Vannieuwenhuyse, E. (1983). Release of neurophysin I and oxytocin by stimulation of genital organs in bulls.J. Endocrinol. 99: 161–171.
Petersen, I., and Stener, I. (1970). An electromyographical study of the striated urethral sphincter, the striated anal sphincter and the levator ani during ejaculation.Electromyography 1: 23–44.
Robbins, M. B., and Jensen, G. D. (1978). Multiple orgasm in males.J. Sex Res. 14: 21–26.
Schams, D., Baumann, G., and Leidl, W. (1982). Oxytocin determination by radioimmunoassay in cattle. II. Effect of mating and stimulation of the genital tract in bulls, cows and heifers.Acta Endocrinol. 99: 218–223.
Sharma, O. P., and Hays, R. L. (1973). Release of an oxytocic substance following genital stimulation in bulls.J. Reprod. Fertil. 35: 359–362.
Sofroniew, M. V. (1983). Morphology of vasopressin and oxytocin neurones and their central and vascular projections. In Leng, B. A., and Leng, G. (eds.),The Neurohypophysis: Structure, Function and Control, Progress in Brain Research, Vol. 60, Elsevier, Amsterdam, pp. 101–114.
Spielberger, C. D., Gorsuch, R. L., and Lushene, R. E. (1970).STAI Manual for the State-Trait Anxiety Inventory Consulting Psychologists Press, Palo Alto, CA.
Stoneham, M. D., Everitt, B. J., Hansen, S., Lightman, S. L., and Todd, K. (1985). Oxytocin and sexual behavior in the male rat and rabbit.J. Endocrinol. 107: 97–106.
Swieczkowski, J. B., and Walter, C. E. (1978). Sexual behavior correlates of female orgasm and marital happiness.J. Nerv. Ment. Dis. 166: 335–342.
Wikland, M., Lindblom B., Wilhelmsson, L., and Wiqvist, N. (1982). Oxytocin, prostaglandins and contractility of the human uterus at term pregnancy.Acta Obstet. Gynecol. Scand. 61: 467–472.
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This research was supported by National Institutes of Health postdoctoral scholarship 5F332HD to M.S.C. and grant AG01437 to J.M.D.
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Carmichael, M.S., Warburton, V.L., Dixen, J. et al. Relationships among cardiovascular, muscular, and oxytocin responses during human sexual activity. Arch Sex Behav 23, 59–79 (1994). https://doi.org/10.1007/BF01541618
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DOI: https://doi.org/10.1007/BF01541618