Abstract.
Calcineurin is a Ca2+- and calmodulin-regulated protein phosphatase that is important in Ca2+-mediated signal transduction. Recent application of the powerful techniques of molecular genetics has demonstrated that calcineurin is involved in the regulation of critical biological processes such as T cell activation, muscle hypertrophy, memory development, glucan synthesis, ion homeostasis, and cell cycle control. Notably, specific transcription factors have been shown to play a key role in regulating these functions, and their calcineurin-mediated dephosphorylation and nuclear translocation appear to be a central event in the signal transduction pathways. This review focuses on recent progress in these areas and discusses the evidence for cross-talk between calcineurin and other signaling pathways.
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Received 5 July 2000; revised 8 September 2000; accepted 8 September 2000
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Sugiura, R., Sio, S., Shuntoh, H. et al. Molecular genetic analysis of the calcineurin signaling pathways . CMLS, Cell. Mol. Life Sci. 58, 278–288 (2001). https://doi.org/10.1007/PL00000855
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DOI: https://doi.org/10.1007/PL00000855