Abstract
In recent years, temporal control of drug delivery has been of interest in basic and applied fields as a new approach to achieve improved drug therapies. This new drug delivery may be achieved by utilization of “intelligent” polymeric materials having the functions of sensing, processing and acting. Stimuli-responsive polymers have been investigated as potential molecular devices to achieve intelligent drug delivery systems such as self-regulating and externally nodulated drug delivery systems.
In this chapter, temperature responsive swelling-shrinking changes in hydrogels were reviewed from the view point of polymer-water interaction and polymer-polymer interaction. In particular, characteristics of interpenetrating polymer networks (IPN) constructed of two distinct polymers which lead to novel temperature-responsive swelling changes were discussed.
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Abbreviations
- PIPAAm:
-
poly(N-isopropyl acrylamide)
- RMA:
-
alkyl methacrylate
- PEO:
-
poly(ethylene oxide)
- APy:
-
poly(acryloylpyrrolidine)
- PMAA:
-
poly(methacrylic acid)
- PAAm:
-
polyacrylamide
- PAAc:
-
poly(acrylic acid)
- IPN-X:
-
Interpenetrating polymer networks of poly(AAm-co-BMA) (BMA X wt%) and PAAc (AAm:AAc=1:1)
- NVP:
-
N-vinyl-2-pyrrolidone
- PBA:
-
m-aminophenyl-boric acid
- PVA:
-
poly(vinyl alcohol)
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© 1993 Springer-Verlag
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Okano, T. (1993). Molecular design of temperature-responsive polymers as intelligent materials. In: Dušek, K. (eds) Responsive Gels: Volume Transitions II. Advances in Polymer Science, vol 110. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0021133
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DOI: https://doi.org/10.1007/BFb0021133
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