Abstract
Aims: We evaluated the prevalence of Helicobacter pylori (HP) in Type 2 diabetic patients and its relationship with dyspeptic symptoms and complications of diabetes. Materials and methods: Seventy-eight Type 2 diabetic patients (54 females, 24 males, mean age: 51.9±10.6 yr) and 71 non-diabetic control subjects were involved in the study. Patients were questioned for dyspeptic symptoms. Cardiovascular autonomic neuropathy, nephropathy and retinopathy were investigated in diabetic patients. Upper gastrointestinal tract endoscopy was performed for all patients and gastric biopsies were obtained and searched for HP. Results: Helicobacter pylori prevalence was significantly higher in diabetic patients than in control subjects (75.6 vs 46%, p<0.05). No differences were found between women and men with regard to HP infection status in diabetic patients. There was no relation between HP and diabetic complications, nephropathy and retinopathy. Helicobacter pylori prevalence was significantly higher in diabetic patients with cardiovascular autonomic neuropathy than in diabetic patients without cardiovascular autonomic neuropathy (90.6 vs 44.0%, p<0.02). Forty-seven subjects with diabetes had symptoms of dyspepsia (60.3%) and the prevalence of HP was higher in these patients (p<0.002). Conclusion: There is a high prevalence of HP infection in diabetic patients and it is correlated with dyspeptic symptoms. Diabetic subjects complicated with cardiovascular autonomic neuropathy and dyspepsia are at high risk of HP infection and should be carefully investigated and considered for eradication therapy.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Xia HH-X, Talley N, Kam E, et al. Helicobacter infection is not associated with diabetes mellitus, nor with gastrointestinal symptoms in diabetes mellitus. Am J Gastroenterol 2001, 96: 1039–46.
Kuipers EJ, Thijis JC, Festen HPM. The prevalence of Heli-cobacter in peptic ulcer disease. Aliment Pharmacol Ther 1996, 1 (Suppl 10): 57–64.
Talley N. The role of Helicobacter pylori in non-ulcer dyspepsia: a debate—against. Gastroenterol Clin North Am 1993, 22: 153–67.
Qvist N, Rasmussen L, Axelsson CK. Helicobacter pylori-associated gastritis and dyspepsia. The influence of migrating complex. Scand J Gastroenterol 1994, 29: 133–7.
Quadri R, Rossi C, Catalfamo E, et al. Helicobacter infection in type 2 diabetic patients. Nutr Metab Cardiovasc Dis 2000, 10: 263–6.
Daniel A. De Luıs, Marcos Lahera, Rafael Cantón, et al. Association of Helicobacter pylori Infection With Cardiovascular and Cerebrovascular Disease in Diabetic Patients. Diabetes Care 1998, 21: 1129–32.
Ewing DJ, Clarke BF: Diagnosis and management of diabetic autonomic neuropathy. Br Med J 1982, 285: 916–8.
Simon L, Tornoczky J, Toth M, et al. The significance of Camplyobacter pylori infection in gastroenterologic and diabetic practice. Orv Hetil 1989, 130: 1325–9.
Malecki M, Bien AI, Galicka-Latala D, et al. The prevalence of Helicobacter pylori infection and types of gastritis in diabetic patients. The Krakow Study. Exp Clin Endocrinol Diabetes 1996, 104: 365–9.
Quatrini M, Valentina B, Ghidoni A, et al. Helicobacter pylori prevalence in patients with diabetes and its relationship to dyspeptic symptoms. J Clin Gastroenterol 2001, 32: 215–7.
Oldenburg B, Diepersloot RJA, Hoekstra JBL High seroprevalence of Helicobacter pylori infection in diabetes mellitus patients. Dig Dis Sci 1996, 41: 458–61.
Persico M, Suozzo R, De Sata M, et al. Non ulcer dyspepsia and helicobacter pylori in type 2 diabetic patients: association with autonomic neuropathy. Diabetes Res Clin Pract 1996, 31: 87–92.
Feldman M, Corbett DB, Ramsey J, Walsh JH, Richardson CT. Abnormal gastric function in longstanding, insulin-dependent diabetic patients. Gastroenterology 1979, 77: 12–7.
Horowitz M, Harding PE, Maddox AF, et al. Gastric and oesophageal emptying in patients with type II diabetes mellitus. Diabetologia 1989; 32: 151–6.
Mearin F, Camilleri A, Malagelada JR. Pyloric dysfunction in diabetes with recurrent nausea and vomiting. Gastroenterology 1986, 90: 1912–6.
Thomas JE, Gibson GR, Darboe MK, et al. Isolation of Helicobacter pylori from human faeces. Lancet 1992, 340: 1194–5.
Shames B, Krajden S, Fuksa M, et al. Evidence for the occurrence of the same strain of Campylobacter pylori in the stomach and dental plaque. J Clin Microbiol 1989, 27: 2849–50.
Bohmer CJ, Klinkenberg-Knol EC, Kuipers EJ, et al. The prevalence of Helicobacter pylori infection among inhabitants and healthy employees of institutes for the intellectually disabled. Am J Gastroenterol 1997, 92: 1000–4.
Drumm B, Perez GI, Blaser MG, et al. Intrafamilial clustering of Helicobacter pylori infection. N Engl J Med 1990, 322: 359–63.
Vaira D, Holton J, Ricci C, et al. The transmission of Helicobacterpylori from stomach to stomach. Aliment Pharmacol Ther 2001, 15 (Suppl 1): 33–42.
Leung WK, Siu KL, Kwok CK, et al. Isolation of Helicobacter pylori from vomitus in children and its implication in gastrooral transmission. Am J Gastroenterol 1999, 94: 2881–4.
Mendall MA, Northfield TC. Transmission of Helicobacter pylori infection. Gut 1995, 37: 1–3.
Kristensson K, Nordborg O, Olsson Y, Saurander P. Changes in the vagus nerve in diabetes mellitus. Acta Pathol Microbiol Scand, 1971, 79: 684–7.
Zitomer BR, Gramm HF, Zozak GP. Gastric neuropathy in diabetes mellitus: clinical and radiological observations. Metabolism 1968, 17: 199–202.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Gulcelik, N.E., Kaya, E., Demirbas, B. et al. Helicobacter pylori prevalence in diabetic patients and its relationship with dyspepsia and autonomic neuropathy. J Endocrinol Invest 28, 214–217 (2005). https://doi.org/10.1007/BF03345375
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03345375