Abstract
The significance of indium-111 antimyosin antibody and thallium-201 dual nuclide single photon emission computed tomography (SPECT) was evaluated in 7 patients with acute myocardial infarction (AMI) who underwent emergency coronary angiography with successful revascularization by intracoronary thrombolysis. Indium-111 antimyosin antibody and thallium-201 dual nuclide SPECT was performed 11 to 36 days after the onset of AMI Antimyosin SPECT images delineated areas of myocardial necrosis in all 7 patients (100%), but planar images detected necrotic areas in only 4 of 7 patients (57 %). Peak CPK-MBs of the 3 patients in which no necrotic area was detected by indium-111 planar image showed a tendency to be smaller. Indium-111 antimyosin antibody/thallium-201 overlap was observed in all patients. The area of overlap was at the center of necrosis in 4 patients (2 anterior infarction, 1 inferior infarction, 1 inferolateral infarction) and at the peripheral portion in 3 patients (all 3 had inferior infarction). Indium-111 antimyosin antibody and thallium-201 dual nuclide SPECT is useful in identifying the localization of myocardial infarction and the overlap of these tracers might reflect the presence of salvaged myocardium adjacent to the necrotic myocardium.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Johnson LL, Seldin DW: The role of antimyosin antibodies in acute myocardial infarction.Semin Nucl Med 19: 238–246, 1989
Johnson LL, Seldin DW, Becker LC, et al: Antimyosin imaging in acute transmural myocardial in- farction: results of a multicenter clinical trial.J Am Coll Cardiol 13: 27–35, 1989
Hashimoto T, Kambara H, Fodo T, et al: Significance of technetium-99m/thallium-201 overlap on simultaneous dual emission computed tomography in acute myocardial infarction.Am J Cardiol 61: 1181–1186, 1988
Beller GA, Khaw BA, Haber E, et al: Localization of radiolabeled cardiac myosin-specific antibody in myocardial infarcts. Comparison with technetium- 99m stannous pyrophosphate.Circulation 55: 74–78, 1977
Zaret BL, DiCola VC, Donabedian RK, et al: Dual radionuclide study of myocardial infarction. Relationships between myocardial uptake of pottasium-43, technetium-99m stannous pyrophosphate, regional myocardial blood flow and creatine phosphokinase depletion.Circulation 53: 422–428, 1976
Khaw BA, Gold HK, Yasuda T, et al: Scintigraphic quantification of myocardial necrosis in patients after intravenous injection of myosin-specific antibody.Circulation 74: 501–508, 1986
Khaw BA, Beller GA, Haber E: Experimental myocardial infarct imaging following intravenous administration of iodine-131 labeled antibody (Fab’)2 fragments specific for cardiac myosin.Circulation 57: 743–750, 1978
Berger H, Lahiri A, Leppo J, et al: Antimyosin imaging in patients with ischemic chest pain: Initial results of Phase III multicenter trial.J Nucl Med 29: 805–806, 1988
Johnson LL, Lerrick KS, Colomilas J, et al: Measurement of infarct size and percentage myocardium infarcted in a dog preparation with single photon emmission computed tomography, thallium-201 and indium-111 monoclonal antimyosin Fab.Circulation 76: 180–190, 1987
Johnson LL, Seidin DW, Keller AM, et al: Dual isotope thallium and indium antimyosin SPECT imaging to identify acute infarct patients at further ischemic risk.Circulation 81: 37–45, 1990
Kondo M, Takahashi M, Matsuda T, et al: Clinical significance of early myocardial99mTc-pyrophosphate uptake in patients with acute myocardial infarction.Am Heart J 113: 250–256, 1987
Khaw BA, Scott J, Fallon JT, et al: Myocardial injury: Quantitation by cell sorting initiated with antimyosin fluorescent spheres.Science 217: 1050–1053, 1982
Reimer KA, Lowe JE, Rasmussen MM, et al: The wave front phenomenon of ischemic cell death 1. Myocardial infarct size vs duration of coronary occlusion in dogs.Circulation 56: 786–794, 1977
Forman R, Cho S, Factor SM, et al: Acute myocardial infarct extension into a previously preserved subendocardial region at risk in dogs and patients.Circulation 67: 117–124, 1983
Schofer J, Spielmann RS, Bromel T, et al: Thallium- 201/technetium-99m pyrophosphate overlap in patients with acute myocardial infarction after thrombolysis: Prediction of depressed wall motion despite thallium uptake.Am Heart J 112: 291–295, 1986
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yoshida, H., Mochizuki, M., Kainouchi, M. et al. Clinical application of Indium-111 antimyosin antibody and Thallium-201 dual nuclide single photon emission computed tomography in acute myocardial infarction. Ann Nucl Med 5, 41–46 (1991). https://doi.org/10.1007/BF03164612
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF03164612