Abstract
Brugada syndrome is an inherited cardiac disease and is associated with a peculiar pattern on the electrocardiogram and an increased risk of sudden death. Electrical storm is a malignant but rare phenomenon in symptomatic patients with Brugada syndrome. We describe a patient who presented with repetitive ICD discharges during two episodes of recurrent VF. After the initiation of isoproterenol infusion and oral quinidine, the ventricular tachyarrhythmias were successfully suppressed. (Neth Heart J 2007;15:151-4.)
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Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. J Am Coll Cardiol 1992;20:1391-6.
Antzelevitch C. The Brugada syndrome: ionic basis and arrhythmia mechanisms. J Cardiovasc Electrophysiol 2001;12:268-72.
Meregalli P, Wilde A, Tan H. Pathophysiological mechanisms of Brugada syndrome: Depolarization disorder, repolarization disorder, or more ? Cardiovasc Res 2005;67:367-78.
Coronel R, Casini S, Koopmann TT, Wilms-Schopman FJG, Verkerk AO, de Groot JR, et al. Right ventricular fibrosis and conduction delay in a patient with clinical signs of Brugada syndrome: a combined electrophysiological, genetic, histopathologic, and computational study. Circulation 2005;112:2769-77.
Brugada J, Brugada R, Antzelevitch C, Towbin J, Nademanee K, Brugada P. Long-term follow-up of individuals with the electrocardiographic pattern of right bundle-branch block and ST-segment elevation in precordial leads V1 to V3. Circulation 2002;105: 173-8.
Eckardt L, Probst V, Smits JPP, Schulze Bahr E, Wolpert C, Schimpf R, et al. Long-term prognosis of individuals with right precordial ST-segment-elevation Brugada syndrome. Circulation 2005;111:257-63.
Brugada J, Brugada R, Brugada P. Natural history of Brugada syndrome: the prognostic value of programmed electrical stimulation of the heart. J Cardiovasc Electrophysiol 2003;14:455-7.
Belhassen B, Glick A, Viskin S. Efficacy of quinidine in high-risk patients with Brugada syndrome. Circulation 2004;110:1731-7.
Maury P, Couderc P, Delay M, Boveda S, Brugada J. Electrical storm in Brugada syndrome successfully treated using isoprenaline. Europace 2004;6:130-3.
Mok NS, Chan NY, Chiu AC. Successful use of quinidine in treatment of electrical storm in Brugada syndrome. Pacing Clin Electrophysiol 2004;27:821-3.
Bettiol K, Gianfranchi L, Scarfo S, Pacchioni F, Pedaci M, Alboni P. Successful treatment of electrical storm with oral quinidine in Brugada syndrome. Ital Heart J 2005;6:601-2.
Yan GC, Antzelevitch C. Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with STsegment elevation. Circulation 1999;100:1660-6.
Lukas A, Antzelevitch C. Phase 2 reentry as a mechanism of initiation of circus movement reentry in canine epicardium exposed to simulated ischemia. Cardiovasc Res 1996;32:593-603.
Kasanuki H, Ohnishi S, Ohtura M, Matsuda N, Nirei T, Isogai R, et al. Idiopathic ventricular fibrillation induced with vagal activity in patients without obvious heart disease. Circulation 1997;95: 2277-85.
Watanabe A, Fukushima Kusano F, Morita H, Miura D, Sumida W, Hiramatsu S, et al. Low-dose isoproterenol for repetitive ventricular arrhythmia in patients with Brugada syndrome. Eur Heart J 2006;27:1579-83.
Brugada P, Brugada R, Antzelevitch C, Brugada J. The Brugada Syndrome. Mal Coeur Vaiss 2005;98:115-22.
Alings M, Dekker L, Sadee A, Wilde A. Quinidine induced electrocardiographic normalization in two patients with Brugada syndrome. Pacing Clin Electrophysiol 2001;24:1420-2.
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Department of Cardiology, Isala Clinics, Zwolle, the Netherlands
A. Elvan Department of Cardiology, Isala Clinics, PO Box 10500, 8000 GM Zwolle, the Netherlands
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Jongman, J.K., Jepkes-Bruin, N., Misier, A.R.R. et al. Electrical storms in Brugada syndrome successfully treated with isoproterenol infusion and quinidine orally. NHJL 15, 151–154 (2007). https://doi.org/10.1007/BF03085972
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DOI: https://doi.org/10.1007/BF03085972