Abstract
Purpose: We tested the hypothesis that propofol, acting in the brain, would either enhance, or have no effect, on lumbar dorsal horn neuronal responses to a noxious mechanical stimulus applied to the hindlimb. We recorded the response of lumbar dorsal horn neurons during differential delivery of propofol to the brain and torso of goats.
Methods: Goats were anesthetized with isoflurane and neck dissections performed which permitted cranial bypass. A laminectomy was made to allow microelectrode recording of lumbar dorsal horn neuronal activity. Isoflurane was maintained at 0.8±0.1 % to both head and torso throughout the study. During cranial bypass propofol was separately administered to the torso (1 mg·kg−1, n=7; 3.75 mg·kg−1, n=8) or cranial (0.04 mg·kg−1, n=7; 0.14 mg·kg−1, n=8) circulations.
Results: Propofol administered to the torso depressed dorsal horn neuronal responses to noxious stimulation: low dose: 500±243 to 174±240 impulses·min−1 at one minute post-injection,P<0.001; high dose: 478 ± 204 to 91±138 impulses·min−1 at one minute post-injection,P<0.05). Propofol administered to the cranial circulation had no effect: low dose: 315±150 to 410±272 impulses·min−1,P>0.05; high dose: 462±261 to 371±196 impulses·min−1,P>0.05.
Conclusions: These data indicate that propofol has a direct depressant effect on dorsal horn neuronal responses to noxious stimulation, with little or no indirect supraspinal effect.
Résumé
Objectif: Vérifier si le propofol, qui agit sur le cerveau, stimulera les réponses neuronales de la corne supérieure lombaire, ou n’aura aucun effet, après l’application d’un stimulus mécanique nocif aux pattes arrières des chèvres. Les réponses ont été enregistrées pendant l’administration différentielle de propofol au cerveau et à la région thoracique.
Méthode: Les chèvres ont été anesthésiées avec de l’isoflurane et la dissection du cou a été réalisée pour permettre une dérivation crânienne. Une laminectomie a été faite pour faciliter l’enregistrement de l’activité neuronale de la corne supérieure lombaire par microélectrode. L’isoflurane a été maintenu à 0,8±0,1 % à la tête et au tronc tout au long de l’étude. Pendant la dérivation crânienne, le propofol a été administré séparément dans la circulation thoracique (l mg·kg−1, n=7; 3,75 mg·kg−1, n=8) ou à la tête (0,04 mg·kg−1, n=7; 0,14 mg·kg−1, n=8).
Résultats: Le propofol administré au niveau thoracique a réduit les réponses neuronales à un stimulus nocif: faible dose: 500±243 à 174±240 impulsions·min−1 à une minute postinjection,P<0.001; forte dose: 478±204 à 91±138 impulsions·min−1 à une minute postinjection,P<0,05). Le propofol dans la circulation crânienne n’a pas eu d’effet: faible dose: 315±150 à 410±272 impulsions·min−1,P>0.05; forte dose: 462±261 à 371±196 impulsions·min−1,P>0,05.
Conclusion: Ces données indiquent que le propofol a un effet dépresseur direct sur les réponses neuronales de la corne supérieure à une stimulation nocive, avec un léger effet supraspinal indirect ou sans effet supraspinal.
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Antognini, J.F., Wang, X.W., Piercy, M. et al. Propofol directly depresses lumbar dorsal horn neuronal responses to noxious stimulation in goats. ja]Can J Anaesth 47, 273–279 (2000). https://doi.org/10.1007/BF03018926
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DOI: https://doi.org/10.1007/BF03018926