Abstract
Hydrostatic pressure antagonizes some, but not all, of the phenomena associated with general anaesthesia. For example, while unconsciousness produced by general anaesthesia in a wide variety of species is reversed by compression, anaesthetic-induced inhibition of synaptic transmission is potentiated by application of pressure. To date, the effect of pressure on analgesia has not been evaluated. In this study, hyperbaric pressure of 75 ata did not antagonize analgesia which had been produced by exposure of mice to 1.2 ata of nitrous oxide. However, the same hyperbaric pressure restored righting in animals which had been anaesthetized with Í .5 ata of nitrous oxide. These data add to the suggestion that the multiple effects of general anaesthetics may be mediated at different loci.
Résumé
La pression hydrostatique antagonise quelques-uns mais pas tous les phénomènes associés à ľanesthésie générale. Alors que ľétat ďinconscience par exemple produit par ľanesthésie générale chez une grande variété ďespèces est antagonisé par la compression, ľinhibition de la transmission synoptique induite par ľanesthésie est augmentée par ľapplication de la pression. A date, les effets de la pression sur ľanalgésie n’ont pas encore été évalués. Dans cette étude, la pression hyperbare de 75 ata n’a pas antagonisé ľanalgésie produite en exposant des souris à 1.2 ata de protoxyde ďazote. Cependant, la même pression hyperbare a restauré le “righting réflexe” chez les animaux qui ont été anesthésiés avec 1.5 ata de protoxyde ďazote. Ces données suggèrent que les effets multiples de ľanesthésie générale sont générés par des centres différents.
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Abbreviations
- ata =:
-
atmospheres absolute
- Ambient pressure is 1 ata =:
-
101.3 kPa (760 mmHg; 14.7 lb · in-2)
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Cohen, P.J. Hyperbaric pressure does not affect the analgesia produced by nitrous oxide in the mouse. Can J Anaesth 36, 40–43 (1989). https://doi.org/10.1007/BF03010885
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DOI: https://doi.org/10.1007/BF03010885