Abstract
The minimum alveolar concentration of sevoflurane necessary to prevent movement in 50 per cent of patients (MAC) was determined to be 2.05 per cent in 20 adult surgical patients. Because this value was higher than the only other experimentally determined human MAC value for sevoflurane (1.71 per cent), MAC was also determined in New Zealand white rabbits. Comparisons of the MAC ratios of sevoflurane to other volatile anaesthetics in both the human and the rabbit suggest that the human MAC value we obtained for sevoflurane is consistent with experimental determinations of MAC of other volatile anaesthetics in humans.
Résumé
La concentration alvéolaire minimale du sévoflurane nécessaire afin de prévenir les mouvements dans 50 per cent des patients (MAC) a été déterminée à 2.05 per cent chez 20 patients adultes subissant une chirurgie. Etant donné que cette valeur était plus élevée que celle obtenue expérimentalement chez les humains avec le sévoflurane (1.71 per cent), le MAC a aussi a été déterminé chez les lapins blanc de la Nouvelle-Zélande. Des comparaisons des rapports de MAC entre le sévoflurane et ďautres agents anesthésiques volatiles tant chez ľhumain que chez le lapin suggèrent que les valeurs du MA C qu’on a obtenues chez ľhumain avec le sévoflurane sont comparables avec celles déterminées expérimentalement pour ďautres agents anesthésiques volatiles chez ľhomme.
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Scheller, M.S., Saidman, L.J. & Partridge, B.L. MAC of sevoflurane in humans and the New Zealand white rabbit. Can J Anaesth 35, 153–156 (1988). https://doi.org/10.1007/BF03010656
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DOI: https://doi.org/10.1007/BF03010656