Summary
Plasma Cholinesterase activity was determined in 71 patients receiving echo-thiophate eyedrops. A twofold reduction in plasma Cholinesterase activity was found in one-third of the patients and a fourfold reduction in one of every seven patients on echothiophate eyedrops. No correlation was found between the duration of the treatment and the plasma Cholinesterase levels found in any of the age groups of patients. Special caution must be exercised with patients on echothiophate iodide eyedrops when succinylcholine or ester-type, hydrolysable local anaesthetics are administered in order to prevent prolonged apnoea and/or toxic reactions.
Résumé
Nous avons étudié l’activité cholinestérasique du plasma chez soixante-et-onze malades qui, durant des périodes allant de deux mois à sept ans, avaient été traités avec de l’iodure d’échothiophate en gouttes dans les yeux. Nous avons recherché les taux d’hydrolyse du chlorure de benzoylcholine et du chlorhydrate de procaïne. Parmi les soixante et onze malades étudiés, 37 pour cent avaient un taux d’hydrolyse inférieur a 50 pour cent de la normale. Les taux d’hydrolyse de la benzoylcholine des malades mâles et femelles, dont l’activité était normale, ont été de 104.5 ± et de 81.4 ± 23 et ceux de la procaine pour les hommes et les femmes étaient 1.12 ± 0.23 et 1.09 ± 0.34 micromole/1 hre./l ml. de plasma. Les taux d’hydrolyse des malades mâles et femelles, dont l’activité était réduite, étaient 44.0 ± 15.9 et 28.0 ± 16.1 pour la benzoylcholine et, pour la procaïne, ils étaient 0.551 ± 0.186 et 0.370 ± 0.138 micromoles/1 hre./l ml. de plasma. Etant donné que, un malade sur sept avait au delà de 75 pour cent de réduction de son activité enzymatique et quelques uns même avaient une réduction supérieure à 90 pour cent il s’impose d’être prudent dans l’usage, chez de tels malades traités par l’iodide d’échothiophate du chlorure de succinylcholine, de certains agents anesthésiques locaux du type ester, de façon à prévenir l’apnée et, respectivement, les réactions toxiques.
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Eilderton, T.E., Farmatt, O. & Zsigmond, E.K. Reduction in plasma cholinesterase levels after prolonged administration of echothiophate iodide eyedrops. Can. Anaesth. Soc. J. 15, 291–296 (1968). https://doi.org/10.1007/BF03008742
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DOI: https://doi.org/10.1007/BF03008742