Abstract
The majority of patients presenting for resection of phaeochromocytoma require some form of antihypertenive therapy during operation. Phentolamine and sodium nitroprusside have both been used successfully for this purpose, but each has disadvantages. This report describes the use of intravenous nitroglycerin, a rapidly acting venodilator with no appreciable toxicity, as the sole antihypertensive agent in two patients with phaeochromocytoma and partial alpha adrenergic blockade. Hypertensive episodes were quickly and effectively controlled in each case. There were no hypotensive periods and no side effects.
Résumé
La majorité des malades qui se présentent pour une résection de phéochromocytome a besoin d’une forme ou d’une autre de thérapie antihypertensive pendant la chirurgie. La phentolamine et le nitroprussiate de sodium ont été utilisés avec succès à cette fin mais ces deux médicaments ont des inconvénients. Les auteurs rapportent l’emploi de nitroglycérine intraveineuse, agent vasodilatateur à action rapide et non toxique, comme seul agent antihypertenseur chez deux patients porteurs de pheochromocytomes et chez qui on avait administré des alpha-bloqueurs. Les épisodes hypertensifs ont été rapidement et effectivement contrôlés et il n’y a pas eu d’épisodes hypotensifs, ni d’effets secondaires.
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McDonald, W.N., Doll, W.A., Schmidt, N. et al. Intravenous nitroglycerin control of blood pressure during resection of phaeochromocytoma. Canad. Anaesth. Soc. J. 29, 108–111 (1982). https://doi.org/10.1007/BF03007986
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DOI: https://doi.org/10.1007/BF03007986