Abstract
The Sr/Ca ratios in plasma, urine, bone, and soft tissues for various ages after weaning in male and female rats were determined to examine the effects of aging on the discrimination between strontium (Sr) and calcium (Ca) under physiological conditions. Age-related changes in the Sr/Ca ratios were similar in all tissues; the Sr/Ca ratios decreased rapidly until about 25-wk-old and then slowly, from that period on, reaching much lower values than in the diet. When the logarithm of the Sr/Ca ratio in each tissue was plotted against the logarithm of age, a linear relationship was observed with statistically significant (p<0.05) regression lines. The higher levels of Sr/Ca ratios in all tissues of the younger rats could be explained by the high efficiency of Sr absorption by the small intestine early in life. Parameters for the equations between age and Sr/Ca ratio differed with tissues, suggesting the existence of specific discrimination mechanisms in each tissue.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
W. Noll,Z. Anorg. Allg. Chem. 199, 193 (1931).
C. L. Comar and R. H. Wasserman,Mineral Metabolism: An Advanced Treatise, C. L. Comar and F. Bronner, eds., Academic, New York, 1964, pp. 523–572.
C. S. Marcus and R. H. Wasserman,Am. J. Physiol. 209, 973 (1965).
C. L. Comar,Strontium Metabolism, J. M. A. Lenihan, J. F. Loutit, and J. H. Martin, eds., Academic, New York, 1967, pp 17–31.
Biochemical Computer Program-P, University of California Press, Berkeley/Los Angeles, CA (1975).
D. G. Papworth and G. Patrick,J. Physiol. 210, 999 (1970).
R. C. Likins, H. G. McCann, A. S. Posner, and D. B. Scott,J. Biol. Chem. 235, 2152 (1960).
J. Samachson, and H. Lederer,Arch. Biochem. Biophys. 88, 355 (1960).
W. F. Neuman, R. Bjornerstedt, and B. J. Mulryan,Arch. Biochem. Biophys. 101, 215 (1963).
C. L. Comar, R. H. Wasserman, S. Ullberg, and G. A. Andrews,Proc. Soc. Exp. Biol. Med. 95, 386 (1957).
H. Spencer, D. Laszlo, and M. Brothers,J. Clin. Invest. 36, 680 (1957).
G. Mazzuoli, J. Samachson, and D. Laszlo,J. Lab. Clin. Med. 52, 522 (1958).
N. Sugihira and K. T. Suzuki,Biol. Trace Elem. Res. 22 (1989).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sugihira, N., Kobayashi, E. & Suzuki, K.T. Age-related changes in strontium to calcium ratios in rat tissues. Biol Trace Elem Res 25, 79–88 (1990). https://doi.org/10.1007/BF02990267
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02990267