Abstract
This review article describes a method for quantifying heterogeneous distribution on Technegas (99mTc-carbon particle radioaerosol) SPECT images by three-dimensional fractal analysis (3D-FA). Technegas SPECT was performed to quantify the severity of pulmonary emphysema. We delineated the SPECT images by using five cut-offs (15, 20, 25, 30 and 35% of the maximal voxel radioactivity), and measured the total number of voxels in the areas surrounded by the contours obtained with each cut-off level. We calculated fractal dimensions from the relationship between the total number of voxels and the cut-off levels transformed into natural logarithms. The fractal dimension derived from 3D-FA is the relative and objective measurement, which can assess the heterogeneous distribution on Technegas SPECT images. The fractal dimension strongly correlate pulmonary function in patients with emphysema and well documented the overall and regional severity of emphysema.
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References
Burch WM, Sullivan PJ, McLaren CJ. Technegas: a new ventilation agent for lung scanning.Nucl Med Commun 1986; 7: 865–871.
Pelitier P, Rimkus DS, Ashburn WL. Lung ventilation scanning with a new carbon particle radioaerosol (Technegas). Preliminary patients studies.Clin Nucl Med 1990; 15: 222–226.
Satoh K, Tanabe M, Takahashi K, Kobayashi T, Nishiyama Y, Yamamoto Y, et al. Assessment of technetium-99m Technegas scintigraphy for ventilatory impairment in pulmonary emphysema: comparison of planar and SPECT images.Ann Nucl Med 1997; 11: 109–113.
Satoh K, Takahashi K, Sasaki M, Kobayashi T, Honjo N, Ohkawa M, et al. Comparison of99mTc-Technegas SPECT with133Xe dynamic SPECT in pulmonary emphysema.Ann Nucl Med 1997; 11: 201–206.
Nagao M, Murase K, Yasuhara Y, Ikezoe J. Quantitative analysis of pulmonary emphysema: three-dimensional fractal analysis of single-photon emission computed tomography images obtained with a carbon particle radioaerosol.AJR 1998; 171: 1657–1663.
Nagao M, Murase K, Ichiki T, Sakai S, Yasuhara Y, Ikezoe J. Quantitative analysis of Technegas SPECT: evaluation of regional severity of emphysema.J Nucl Med 2000; 41: 590–595.
Mandelbrot B. How long is the coast of Britain? Statistical self-similarity and fractal dimension.Science 1967; 156: 636–638.
Mandelbrot B.Fractal Geometry of Nature. San Francisco; Freeman, 1982.
Sirr SA, Junenemann PJ, Tom H, Boudreau RJ, Chandler RP, Loken MK. Effect of ethanol on droplet size, efficiency of delivery, and clearance characteristics of technetium-99m DTPA aerosol.J Nucl Med 1985; 26: 643–646.
Peltier P, Bardies M, Chetanneau, A, Chatal JF. Comparison of technetium-99m C and phytate aerosol in ventilation studies.Eur J Nucl Med 1992; 19: 349–354.
Peltier P, Faucal P, Chetanneau, A, Chatal JF. Comparison of technetium-99m aerosol and krypton-81 m in ventilation studies for the diagnosis of pulmonary embolism.Nucl Med Commun 1990; 11: 631–638.
Nelson T. Fractal physiologic complexity, scaling, and opportunities for imaging.Invest Radiol 1990; 25: 1140–1148.
Zhang X, Hirano H, Yamamoto K, Kusaka Y, Sugimoto K, Kimoto T. Technegas ventilation SPECT for evaluating silicosis in comparison with computed tomography.Ann Nucl Med 1996; 10: 165–170.
Chung HW, Huang YH. Fractal analysis of nuclear medicine images for the diagnosis of pulmonary emphysema: interpretations, implications, and limitations.AJR 2000; 174: 1055–1059.
Nagao M, Murase K, Kikuchi T, Ikeda M, Nebu A, Fukuhara R, et al. Fractal analysis of cerebral blood flow distribution in Alzheimer's disease.J Nucl Med 2001; 42: 1446–1450.
Xu J, Moonen M, Johansson A, Gustafsson A, Bake B. Quantitative analysis of inhomogeneity in ventilation SPET.Eur J Nucl Med 2001; 28: 1795–1800.
Kuikka JT, Bassingthwaighte JB, Henrich MM. Mathematical modeling in nuclear medicine.Eur J Nucl Med 1991; 18: 351–361.
Kuikka JT. Effect of tissue heterogeneity on quantification in positron emission tomography.Eur J Nucl Med 1995; 22: 1457–1458.
Kuikka JT, Hartikainen P. Heterogeneity of cerebral blood flow: a fractal approach.Nuklearmedizin 2000; 39: 37–42.
American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma.Am Rev Respir Dis 1987; 136: 225–244.
Cooper J, Trulock E, Triantafillou A, Patterson G, Pohl M, Deloney P, et al. Bilateral pneumonectomy (volume reduction) for chronic obstructive pulmonary disease.J Thorac Cardiovasc Surg 1995; 109: 106–119.
Daniel TM, Chan BB, Bhaskar V, Parekh JS, Walters PE, Reeder J et al. Lung volume reduction surgery, case selection, operative technique, and clinical results.Ann Surg 1996; 223: 526–531.
Slone RM, Pilgram TK, Gierada DS, Sagel SS, Glazer HS, Yusen RD, et al. Lung volume reduction surgery: comparison of preoperative radiographic features and clinical outcome.Radiology 1997; 205: 685–693.
Suga K, Kume N, Matsunaga N, Ogasawara N, Motoyama K, Hara A, et al. Relative preservation of peripheral lung function in smoking-related pulmonary emphysema: assessment with99mTc-MAA perfusion and dynamic133Xe SPET.Eur J Nucl Med 2000; 27: 800–806.
Suga K, Tsukuda T, Awaya H, Matsunaga N, Sugi K, Esato K, et al. Interactions of regional respiratory mechanics and pulmonary ventilatory impairment in pulmonary emphysema: assessment with dynamic MRI and xenon-133 single-photon emission CT.Chest 2000; 117: 1646–1655.
Imai T, Sasaki Y, Shinkai T, Ohishi H, Nezu K, Nishimoto Y, et al. Clinical evaluation of99mTc-Technegas SPECT in thoracoscopic lung volume reduction surgery in patients with pulmonary emphysema.Ann Nucl Med 2000; 14: 263–269.
Thurlbeck WM, Muller NL. Emphysema: Definition, imaging, and quantitation.AJR 1994; 163: 1017–1025.
Stern EJ, Frank MS. CT of the lung in patients with pulmonary emphysema: diagnosis, quantitation, and correlation with pathologic and physiologic findings.AJR 1994; 162: 791–798.
Postma DS, Sluiter HJ. Prognosis of chronic pulmonary disease: the Dutch experience.Am Rev Respir Dis 1989; 140: 100–105.
Nagao M, Murase K, Ichiki T, Sakai S, Yasuhara Y, Ikezoe J. Relationship between regional severity of emphysema and coronary heart disease.Ann Nucl Med 2000; 14: 369–372.
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Nagao, M., Murase, K. Measurement of heterogeneous distribution on Technegas SPECT images by three-dimensional fractal analysis. Ann Nucl Med 16, 369–376 (2002). https://doi.org/10.1007/BF02990073
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DOI: https://doi.org/10.1007/BF02990073