Abstract
Bioassay-guided fractionation has led to the isolation of triterpenoid saponins such as Acutoside A (3-O-[O-β-D-glucopyranosyl-(1→2)-O-β-D-glucopyranosyl] oleanolic acid) from the whole plants ofViola hondoensis. Among them, Saponin 1 exhibited potent inhibitory activity against matrix metalloproteinase (MMP)-1, and prevented the UV-induced changes in the MMP-1 expression. In addition, compound was isolated from this plant for the first time.
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Bemhard, E. J., Gruber, S. B., and Muschel, R. J., Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells.Proc. Nat. Acad. Sci. U.S.A., 91, 4293–4297 (1994).
Carnat, A. P., Camet, A., Fraisse, D., Lamaison, J. L., Heitz, A., Wylde, R., and Teulade, J. C., Violarvensin, a new flavone di- C-glycoside fromViola arvensis.J. Nat. Prod., 61, 272–274 (1998).
Chambers, A. F. and Matrisian, L. M., Changing views of the role of matrix metalloproteinases in metastasis.J. Natl. Cancer Inst., 89, 1260–1270 (1997).
Fisher, G. J., Datta, S. C., Taiwan H. S., Wang, Z. Q., Varani, J., Kang, S., and Voorhees, J. J., Molecular basis of sun-induced premature skin ageing and retinoid antagonism.Nature, 379, 335–339 (1996).
Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S,, and Voorhees, J. J., Pathophysiology of premature skin aging induced by ultraviolet light.Nat. Engl. J. Med., 337, 1419–1428 (1997).
Gilchrest, B. A., Skin aging and photoaging: an overview.J. Am. Acad. Dermatol., 21, 610–613 (1989).
Lee, Y. N., Flora of Korea, Kyohak-Sa, Seoul, Korea. (1996).
Lindholm, P., Goransson, U., Johansson, S., Claeson, P., Gullbo, J., Larsson, R., Bohlin, L., and Backlund, A., Cyclotides: a novel type of cytotoxic agents.Mol. Cancer, Ther., 1, 365–369 (2002).
Mosmann, T., Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.J. Immunol. Methods, 65, 55–63 (1983).
Nagao, T., Tanaka, R., Iwase, Y., Hanazono, H., and Okabe, H., Studies on the constituents ofLuffa acutangula Roxb. I. Structures of acutosides A-G, oleanane-type triterpene saponins isolated from the herb.Chem. Pharm. Bull., 39, 599–603 (1991).
Rice-Evans, C. A., Miller, N. J., and Paganga, G., Structure-antioxidant activity relationships of flavonoids and phenolic acids.Free Radical Biol. Med., 20, 933–956 (1996).
Salah, N., Miller, N. J., Paganga, G., Tijburg, L., Bolwell, G. P., and Rice-Evans, C., Polyphenols flavanols as scavengers of aqueous phase radicals and as chain-breaking antioxidants.Arch. Biochem. Biophys., 322, 339–346 (1995).
Schuele, S. and Lederman, R. J., Long-term outcome of focal dystonia in string instrumentalists.Mov. Disord., 19, 43–48 (2004).
Seo. J. Y., Lee. S. H., Youn. C. S., Choi. H. R., Rhie. G. E., Cho. K. H., Kim. K. H., Park. K. C., Eun. H. C., and Chung. J. H., Ultraviolet radiation increases tropoelastin mRNA expression in the epidermis of human skinin vivo.J. Invest. Dermatol., 116, 915–919 (2001).
Svangard. E., Goransson. U., Smith. D., Verma. C., Backlund. A., Bohlin. L., and Claeson. P., Primary and 3-D modeled structures of two cyclotides fromViola odorata.Phytochemistry, 64, 135–142 (2003).
Tennstedt, D., Comphaut, P., Dooms-Goossens, A., and Lachapelle, J. M., Dermatoses of the affecting violin and viola players.Derm Beruf Umwelt, 27, 165–169 (1979).
Varani, J., Warner, R. L., Gharaee-Kermani, M., Phan, S. H., Kang, S., Chung, J. H., Wang, Z. Q., Datta, S. C., Fisher, G. J., and Voorhees, J. J., Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin.J. Invest. Dermatol., 114, 480–486 (2000).
Xie, C., Veitch, N. C., Houghtn, P. J., and Simmonds, M. S., Flavone C-glycosides fromViola yedoensis MAK/NO.Chem. Pharm. Bull., 51, 1204–1207 (2003).
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Moon, HI., Chung, J.H., Lee, JK. et al. Triterpenoid saponin fromviola hondoensis W. Becker et H Boss. and their effect on mmp-1 and type i procollagen expression. Arch Pharm Res 27, 730–733 (2004). https://doi.org/10.1007/BF02980140
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DOI: https://doi.org/10.1007/BF02980140