Abstract
Several diacetoxy acetal analogues have been synthesized from santonin and assessed for their ability of inducing or enhancing the differentiation of human HL-60 leukemia cells. The compounds themselves had little effect on HL-60 cell differentiation. However, three analogues,2a, 3a, and5b, synergistically enhanced 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]-induced HL-60 cell differentiation when combined with 5 nM of dihydroxyvitamin D3 [1,25-(OH)2D3], a well-known differentiation inducer. Especially, the compound5b profoundly enhanced the 1,25-(OH)2D3]-induced HL-60 cell differentiation.
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Kim, S.H., Chung, S.Y., Kim, T.S. et al. Synthesis of diacetoxy acetal derivatives of santonin and their enhancing effects on HL-60 leukemia cell differentiation. Arch Pharm Res 29, 40–45 (2006). https://doi.org/10.1007/BF02977466
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DOI: https://doi.org/10.1007/BF02977466