Abstract
Two isoflavoneC-glucosides, puerarin (1) and PG-3 (2), a but-2-enolide, (±)-puerol B (3), two isoflavoneO-glucosides, daidzin (4) and genistin (5), and three pterocarpans, (−)-medicarpin (6), (−)-glycinol (7) and (−)-tuberosin (8), were isolated from a MeOH extract of the roots ofPueraria lobata, using anin vitro bioassay based on the inhibition of the formation of advanced glycation end products (AGEs) to monitor chromatographic fractionation. The structures of1–8 were determined by spectroscopic data interpretation, particularly by 1D- and 2D-NMR studies, and by comparison of these data with values in the literature. All of the isolates (1–8) were evaluated for their inhibitory activity on AGEs formationin vitro. Of these, puerarin (1), PG-3 (2), and (±)-puerol B (3) exhibited more potent inhibitory activity than the positive control aminoguanidine.
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Kim, J.M., Lee, Y.M., Lee, G.Y. et al. Constituents of the roots ofPueraria lobata inhibit formation of advanced glycation end products (AGEs). Arch Pharm Res 29, 821–825 (2006). https://doi.org/10.1007/BF02973900
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DOI: https://doi.org/10.1007/BF02973900