Abstract
The chromatographic separation of the MeOH extract of the roots ofAinsliaea acerifolia (Compositae) led to the isolation of six known terpenes and two known lignans. Their structures were identified by spectroscopic methods as mokko lactone (1), betulonic acid (2), betulinic acid (3), zaluzanin C (4), 1β-hydroperoxygermacra-4(15), 5, 10(14)-triene (5), pluviatilol (6), (+)-syringaresinol (7), and glucozaluzanin C (8). Compounds1∼4 and8 showed non-specific significant cytotoxicity against five human tumor cell lines with ED50 values ranging from 0.36∼5.54 μg/mL.
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References
Ando, M., Kusaka, H., Ohara, H., Takase, K., Yamaoka, H. and Yanagi, Y., Studies on the syntheses of sesquiterpene lactones.J. Org. Chem., 54, 1952–1960 (1989).
Banerji, A. and Pal, S., Constituents ofPiper sylvaticum: structure of sylvatesmin.J. Nat. Prod., 45, 672–675 (1982).
Bohlmann, F. and Gupta, R. K., Eremophilene and germacrene derivatives fromSenecio glanduloso-pilosus.Phytochemistry, 21, 2595–2597 (1982).
Corrie, J. E. T., Green, G. H. and Taylor, W. C., The chemical constituents of AustralianZanthoxylum species.Aust. J. Chem., 23, 133–145 (1970).
Deyama, T., Ikawa, T., Kitagawa, S. and Nishibe, S., The constituents ofEucommia ulmoides Oliv. V. Isolation of dihydroxydehydrodiconiferyl alcohol isomers and phenolic compounds.Chem. Pharm. Bull, 35, 1785–1789 (1987).
Gonzalez, A. G., Amaro, J., Fraga, B. M. and Luis, J., 3-Oxo-6β-hydroxyolean-18-en-oic acid fromOrthopterygium huancuy.Phytochemistry, 22, 1828–1830 (1983).
Hikino, H., Meguro, K., Kusano, G. and Takemoto, T., Structure of Mokko lactone.Yakugaku Zasshi, 87, 70–74 (1967).
Ishii, H., Ishkawa, T., Mihara, M. and Akaike, M., Studies on the chemical constituents ofRutaceous plants. XLVIII. The Chemical constituents ofXanthoxylum ailanthoides Sieb. et Zucc.,Yakugaku Zasshi, 103, 279–292 (1983).
Jung, C. M., Kwon, H. C., Choi, S. Z., Lee, J. H., Lee, D. J., Ryu, S. N., and Lee, K. R., Phytochemical constituents ofAnisliaea acerifolia.Kor. J. Pharmacogn., 31, 125–129 (2000).
Kim, C. M., Shin, M. K., Lee, K. S. and Ahn, D. K., The Dictionary of Chinese Drugs, Jeong Dam Press, Seoul, pp. 727, 1360, 3448, 3870, 5476, 5721, 5918, (1999).
Kisiel, W., 8-Epidesacylcynaropicrin from Crepis capillaris.Planta Med., 49, 246–247 (1983).
Kojima, H., Tominaga, H., Sato, S., and Ogura, H., Pentacyclic triterpenoids fromPrunella vulgaris.Phytochemistry, 26, 1107–1111 (1987).
Lee, K. R., Peroxide constituents in the natural product research.Kor. J. Pharmacogn., 22, 145–155 (1991).
Li, Y., and Jia, Z. J., Guaianolides fromSaussurea involucrate.Phytochemistry, 28, 3395–3397 (1999).
Macrae, W. D. and Towers, G. H. N., Non-alkaloidal constituents ofVirola elongata Bark.Phytochemistry, 24, 561–566 (1985).
Mahato, S. B., and Kundu, A. P.,13C NMR spectra of pentacyclic triterpenoids — a complilation and some salient features.Phytochemistry, 37, 1517–1575 (1994).
Marco, J. A., Sanz, J. F., Albiach, R., Rustaiyan, A., and Habibi, Z., Bisabolene derivatives and sesquiterpene lactones fromCousinia species.Phytochemistry, 32, 395–400 (1993).
Marco, J. A., Sanz-Cervera, J. F., Yuste, A., and Oriola, M. C., Sesquiterpene lactones and dihydroflavonols fromAndryala andUrospermum species.Phytochemistry, 36, 725–729 (1994).
Marco, J. A., Sanz-cervera, J. F., Garcia-lliso, V., Susanna, A., and Garcia-Jacas, N., Sesquiterpene lactones, lignans and aromatic esters fromCheirolophus species.Phytochemistry, 37, 1101–1107 (1994).
Nagumo, S., Izawa, K., Higashiyama, K. and Nagai, M., A bitter principle ofPertya robusta (Maxim.) Beauv.: Glucozaluzanin C.Yakugaku Zasshi, 100, 427–433 (1980).
Singhal, A. K., Chowdhury, P. K., and Sharma, R. P., Guaianolides fromTricholepis glaberrima.Phytochemistry, 21, 462–463 (1982).
Skehan, P., Storeng, R., Scudiero, D., Monks, A., McMahon, J., Vistica, D., Warren, J. T., Bokesch, H., Kenney, S., and Boyd, M. R., New colorimetric cytotoxicity assay for anticancer-drug screening.J. Natl. Cancer Inst., 82, 1107–1112 (1990).
Tanaka, H., Nakamura, T., Ichino, K. and Ito, K., A lignan fromActinodaphne longifolia.Phytochemistry, 28, 952–954 (1989).
Toshio, M., and Seigo, F., Sesquiterpene lactones fromAnisliaea acerifolia Sch. Bip. andA. dissecta Franch. et Sav,Chem. Pharm. Bull., 32, 3043–3046 (1984).
Yuuya, S., Hagiwara, H., Suzuki, T., Ando, M., Yamada, A., Suda, K., Kataoka, T. and Nagai, K., Guaianolides as immunomodulators. Synthesis and biological activities of dehydrocostus lactone, mokko lactone, eremanthin, and their derivatives.J. Nat. Prod., 62, 22–30 (1999).
Zdero, C., Bohlmann, F., and Wasshausen, D. C., Guaianolides fromBrachylaena species.Phytochemistry, 30, 3810–3811 (1991).
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Choi, S.Z., Yang, M.C., Choi, S.U. et al. Cytotoxic terpenes and lignans from the roots ofAinsliaea acerifolia . Arch Pharm Res 29, 203–208 (2006). https://doi.org/10.1007/BF02969394
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DOI: https://doi.org/10.1007/BF02969394