Abstract
Altered cell signaling is the molecular basis for cell proliferation occurring in association with several gamma herpesvirus infections. Three gamma herpesviruses, namely EBV/HHV-4, KSHV/HHV-8 and the MHV-68 (and/or MHV-72) and their unusual cell-pirated gene products are discussed in this respect. The EBV, KSHV as well as the MHV DNA may persist lifelong in an episomal form in the host carrier cells (mainly in lymphocytes but also in macrophages, in non-hornifying squamous epithelium and/or in blood vessel endothelial cells). Under conditions of extremely limited transcription, the EBV-infected cells express EBNA1 (EB nuclear antigen 1), the KSHV infected cells express LANA1 (latent nuclear antigen 1), while the MHV DNA carrier cells express the latency-associated protein M2. With the full set of latency-associated proteins expressed, EBV carrier cells synthesize additional EBNAs and at least one LMP (latent membrane protein 1). The latent KSHV carrier cells, in addition to LANA1, may express a viral cyclin, a viral Fas-DD-like ICE inhibitor protein (vFLIP) and a virus-specific transformation protein called kaposin (K12). In MHV latency with a wide expression of latency-associated proteins, the carrier cells express a LANA analogue (ORF73), the M3 protein, the K3/IE (immediate early) proteins and M11/bcl-2 homologue proteins. During the period of limited gene expression, the latency-associated proteins serve mainly for the maintenance of the latent episomal DNA (a typical example is EBNA1). In contrast, during latency with a broader spectrum gene expression, the virus-encoded products activate transcription of otherwise silenced cellular genes, which leads to the synthesis of enzymes capable of promoting not only viral but also cellular DNA replication. Thus, the latency-associated proteins block apoptosis and drive host cells towards division and immortalization. Proliferation of hemopoetic cells, which had become gamma herpesvirus DNA carriers, can be initiated and strongly enhanced in the presence of inflammatory cytokines and by virus-encoded analogues of interleukins, chemokines and IFN regulator proteins. At early stages of tumor formation, many proliferating hemopoetic and/or endothelium cells, which had became transcriptionally active under the influence of chemokines and cytokines, may not yet be infected. In contrast, at later stages of oncogenesis, the virus-encoded proteins, inducing false signaling and activating the proliferation pathways, bring the previously infected cells into full transformation burst.
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Abbreviations
- AIDS:
-
acquired immunodeficiency virus
- AM:
-
adherent mononuclear (cells)
- Apo1:
-
apoptosis receptor 1 (Fas receptor)
- ART:
-
activator of replication and transcription
- BL:
-
Burkitt’s lymphoma
- BRLF:
-
BamHI R leftward fragment (EBV DNA)
- BZLF:
-
BamHI Z leftward fragment (EBV DNA)
- CD:
-
cluster of differentiation (leukocyte marker)
- cdk:
-
cyclin-dependent kinases
- c-jun:
-
cellular ju-nana (japanese expression for 17 sarcoma virus)
- CMV:
-
cvtomegalovirus
- CNS:
-
centraf nervous system
- CREB:
-
(cAMP-response element)-binding protein
- CTAR:
-
C-terminal activator regions
- DD:
-
death domain
- DED:
-
death effector domain
- DS:
-
dyad symmetry (EBV DNA region)
- EBER:
-
Epstein—Barr encoded nonpolyadenylated RNA
- EBNA:
-
Epstein—Barr nuclear antigen
- EBV:
-
Epstein—Barr virus
- FADD:
-
Fas receptor-associated death domain
- Fas:
-
FS-7 associated cell surface (protein)
- FGARAT:
-
N-formylglycinamide ribotide aminotransferase
- FLICE:
-
FADD-like interleukin converting enzyme inhibitor protein (vFLIP)
- FR:
-
family of repeats
- GAS:
-
gamma-activated sequence
- GPCR:
-
G-protein coupled receptor
- HAX-1:
-
HS-1 associated protein X-1
- HHV:
-
human herpesvirus
- HIV:
-
human immunodeficiency virus
- HL:
-
Hodgkin’s lymphoma
- HLA:
-
human leukocyte antigen
- HS-1:
-
hemopoetic specific protein 1
- HSV-1:
-
herpes simplex virus 1
- HVS:
-
herpesvirus saimiri
- ICE:
-
interleukin-1β converting enzyme
- IE:
-
immediate early proteins
- IFN:
-
interferon
- IKK:
-
inactivator kinases
- IL:
-
interleukin
- IM:
-
infectious mononucleosis
- IRF:
-
IFN regulating factor
- IS:
-
immunosuppression
- ITAM:
-
immunoreceptor tyrosine-based activator motif
- K-bZIP:
-
KSHV analogue of the EBV-specified Zta
- KIP/CIP:
-
kinase inhibitor protein/cyclin inhibitor protein
- KS:
-
Kaposi’s sarcoma
- KSHV:
-
Kaposi’s sarcoma (associated) herpesvirus
- LANA:
-
latent nuclear antigen
- LCL:
-
lymphoblastoid cell lines
- LMP:
-
latent membrane protein
- LPD:
-
lymphoproliferative disorders
- LTP:
-
large tegument protein
- MAPK:
-
mitogen activated protein kinase
- MapK/MKK:
-
mitogen activated kinase/kinase cascade
- MCD:
-
multicentric Castleman disease
- MCP:
-
monocyte chemoattractant proteins
- MHV:
-
murine herpesvirus
- NFAT:
-
nuclear factor activator of T cells
- NF-κB:
-
nuclear factor κB
- NIK:
-
NF-κB inducing kinase
- NPC:
-
nasopharyngeal carcinoma
- OBP:
-
ori-binding protein
- PAN:
-
polyadenylated nuclear RNA species
- PEL:
-
primary effusion lymphoma
- Rb:
-
retinoblastoma (proteins)
- RR:
-
ribonucleotide reductase (genes)
- RS:
-
Reed—Sternberg (cells)
- Rta:
-
R transactivator protein (R fragment encoded)
- Sos:
-
son of sevenless (protein)
- STAT:
-
signaling transduction and transcription
- TK:
-
thymidine kinase
- TNF:
-
tumor necrosis factor
- TNFR:
-
TNF receptor
- TPA:
-
4β,9α,12β,13α,20-pentahydroxytiglia-1,6-dien-3-one 12β-myristate 13α-acetate (‘12-O-tetradecanoylphorbol 13-acetate’)
- TRADD:
-
TNFR-associated death domain
- TRAF:
-
TNFR-associated factor
- vCyclin:
-
viral cyclin
- VEGF:
-
vascular endothelial growth factor
- vFLIP:
-
viral FLICE (caspase 1) inhibitor protein
- vGPCR:
-
viral G-protein coupled receptor
- vMIP:
-
viral macrophage inflammatory protein
- VZV:
-
varicella zoster virus
- Zta:
-
Z (‘Zebra’) transactivator protein (Z fragment encoded)
References
Adams J.M., Cory S.: The bcl-2 protein family: arbiters of cell survival.Science281, 1322–1325 (1998).
Ahn J.W., Powell K.L., Kellam P., Alber D.G.: Gamma herpesvirus lytic gene expression as characterized by DNA array.J. Virol.76, 6244–6256 (2002).
Akhtar M., Bunuan H., Ali M., Godwin J.: Kaposi’s sarcoma in renal transplant patients: ultrastructural and immunoperoxidase study of four cases.Cancer53, 258–266 (1984).
Albrecht J.C., Nicholas J., Biller D., Cameron K.R., Biesinger B., Newman C., Wittmann S., Craxton M.A., Coleman H., Fleckenstein B., Honess R.W.: Primary structure of the herpesvirus saimiri genome.J.Virol.66, 5047–5058 (1992).
Albrecht J.C.: Primary structure of the herpesvirus ateles genome.J.Virol.74, 1033–1037 (2000).
Ambinder R.F., Shah W.A., Rawlings D.R., Hayward G.S., Hayward S.D.: Definition of the sequence requirements for binding of the EBNA1 protein to its palindromic target sites in Epstein—Barr virus DNA.Cell58, 527–535 (1990).
Ambinder R.F., Mullen M.A., Chang Y.N., Hayward G.S., Hayward S.D.: Functional domains of Epstein—Barr virus nuclear antigen EBNA1.J.Virol.65, 1466–1478 (1991).
Armstrong A.A., Gallagher A., Krajewski A.S.: The expression of the EBV latent membrane protein (LMP1) is independent of CD23 and bcl-2 in Reed—Stemberg cells.Histopathology21, 72–73 (1992).
Arvanitakis L., Mesri E.A., Nador R.G., Said J.W., Asch A.S., Knwoles D.M., Cesarman E.: Establishment and characterization of a primary effusion (body cavity based) lymphoma cell line (BC-3) harboring Kaposi’s sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of Epstein—Barr virus.Blood88, 2648–2654 (1996).
Arvanitakis L.A., Geras-Raaka E., Varma A., Gershengorn M.C., Cesarman E.: Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation.Nature385, 347–349 (1997).
Askenazi A., Dixit V.M.: Death receptors: signaling and modulation.Science281, 1305–1308 (1998).
Baer R., Bankier A.T., Biggin M.D., Deininger P.L., Farrell P.J., Gibson T.J., Hatfull G., Hudson G.S., Satchwell S.C., Seguin C., Tufnell P.S., Barrell B.G.: DNA sequence and expression of the B95-8 Epstein—Barr virus genome.Nature310, 207–211 (1984).
Baggiolini M., Dewald B., Moser B.: Human chemokines: an update.Ann.Rev.Immunol.15, 675–705 (1997).
Baichwal V.R., Sugden B.: Transformation of Balb/c 3T3 cells by the BNLF-1 gene of Epstein—Barr virus.Oncogene2, 461–467 (1988).
Bais C., Santomasso B., Coso O., Arvanitakis L., Raaka E.G., Gutkind J.S., Asch A.S., Cesarman E., Gerhengorn M.C., Mesri E.A.: G-Protein-coupled receptor of Kaposi’s sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator.Nature391, 86–89 (1998).
Bauerle P., Baltimore D.: I-κB: a specific inhibitor of the NF-κB transcription factor.Science242, 540–546 (1988).
Bello L.J., Davison A.J., Glenn M.A., Whitehouse A., Rethmeier N., Schultz T.F., Clements J.B.: The human herpesvirus 8 ORF57 gene and its properties.J.Gen.Virol.80, 3207–3215 (2000).
van Berkel V., Pretter K., Virgin H.W. IV,Speck S.H.: Identification and initial characterization of the murine gamma herpesvirus 68 gene M3, encoding an abundantly secreted protein.J.Virol.73, 4524–4529 (1999).
Bernheim A., Berger R., Lenoir G.: Cytogenetic studies on African Burkitt’s lymphoma cell lines; t(8:14), t(2:8) and t(8:22) translocations.Cancer Genet.Cytogenet.3, 307–315 (1981).
Bieleski L., Talbot S.: Kaposi’s sarcoma-associated herpesvirus vCyclin open reading frame contains an internal ribosomal entry site.J.Virol.75, 1864–1869 (2001).
Blaškovič D., Stančekova M., Svobodová J., Mistriková J.: Isolation of five strains of herpesviruses from two species of free living small rodents.Acta Virol.24, 468–473 (1980).
Blaškovič D., Stanekova D., Rajčani J.: Experimental pathogenesis of murine herpesvirus in newborn mice.Acta Virol.28, 225–231 (1984).
Boshoff C., Endo Y., Collins P.D., Takeuchi Y., Reeves J.D., Schweickart V.L., Siani M.A., Sasaki T., Williams T.J., Gray P.W., Moore P.S., Chang Y., Weiss R.A.: Angiogenic and HIV inhibitory functions of KSHV-encoded chemokines.Science278, 290–294 (1997).
Bublot M., Lomonte P., Lequarre A.S., Albrecht J.C., Nicholas J., Fleckenstein B., Pastoret P.P., Thiry E.: Genetic relationships between bovine herpesvirus 4 and the gamma herpesviruses Epstein—Barr virus and herpesvirus saimiri.Virology190, 654–665 (1992).
Burkhardt A.L., Bolem J.B., Kieff E., Longnecker R.: An Epstein—Barr virus transformation-associated membrane protein interacts with Src family tyrosine kinases.J.Virol.66, 5161–5167 (1992).
Burkitt D.A.: A children’s cancer dependent upon climatic factors.Nature194, 232–234 (1962).
Burysek L., Yeow W.S., Lubyova B., Kellum M., Schafer S.L., Huang Y.Q., Pitha P.M.: Functional analysis of human herpesvirus 8-encoded viral interferon regulatory factor I and its association with cellular interferon regulatory factors and p300.J.Virol.73, 7334–7342 (1999).
Cannon J.S., Nicholas J., Orenstein J.M., Mann R.B., Murray P.G., Browning P.J., di Guiseppe J.A., Cesarman E., Hayward G.S., Ambinder R.F.: Heterogeneity of viral IL-6 expression in HHV-8 associated disease.J.Infect.Dis.180, 824–828 (1999).
Castleman B., Iverson L., Menedey V.P.: Localized mediastinal lymph-node hyperplasia resembling thymoma.Cancer9, 822–830 (1956).
Cesarman E., Nador R.G., Bai F., Bohensky R.A., Russo J.J., Moore P.S., Chang Y., Knowles D.M.: Kaposi’s sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologues which are expressed in Kaposi’s sarcoma and malignant lymphoma.J.Virol.70, 8218–8223 (1996).
Chabot-Fletcher M.: Cellular signaling to NF-kB: role in inflammation and therapeutic promise, pp. 23–38 in G.L. Letts, D.W. Morgan (Eds):Inflammatory Process: Molecular Mechanisms and Therapeutic Opportunities. Birkhauser, Basel-Boston-Berlin 2000.
Chang Y., Moore P.S., Talbot S.J.: Cyclin encoded by KS herpesvirus.Nature382, 410–411 (1996).
Chang J., Ganem D.: On the control of late gene expression in Kaposi’s sarcoma-associated herpesvirus (human herpesvirus 8).J.Gen.Virol.81, 2039–2047 (2000).
Chi T., Carey M.: The ZEBRA activation domain: modular organization and mechanism of action.Mol.Cell.Biol.13, 7045–7055 (1993).
Choi P.H.K., Sven M.W.M., Haung D.P., Lo K.-W., Lee J.C.K.: Nasopharyngal carcinoma: genetic changes, Epstein—Barr virus infection or both. A clinical study of 36 patients.Cancer72, 2873–2878 (1993).
Choi J.K., Lee B.S., Shim S.N., Li M., Jung J.U.: Identification of the novel K15 gene at the rightmost end of the Kaposi’s sarcoma associated herpesvirus genome.J.Virol.74, 436–446 (1999).
Cohen B.D., Goldstein D.J., Rutlege L., Wass W.C., Lowy D.R., Schlegel R., Schiller J.T.: Transformation specific interaction of the bovine papillomavirus E5 oncoprotein with the platelet derived growth factor receptor domain and the epidermal growth factor receptor cytoplasmic domain.J.Virol.67, 5303–5311 (1993).
Craighead J.E.: Epstein-Barr virus (EBV), pp. 117–146 inPathology and Pathogenesis of Human Viral Disease. Academic Press, London-San Diego 2000a.
Craighead J.E.: Kaposi’s sarcoma associated herpesvirus (KSHV, HHV-8), pp. 171–188 inPathology and Pathogenesis of Human Viral Disease. Academic Press, London-San Diego 2000b.
Dairaghi D.J., Fan R.A., McMaster B.E., Hanley M.R., Schall T.J.: HHV-8 encoded vMIP-1 selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines.J.Biol.Chem.274, 21569–21574 (1999).
Dalla-Favera R., Bregni M., Erikson J., Patterson D., Gallo R.W., Croce C.M.: Humanc-myc gene is located in the region of chromosome 8 that is translocated in Burkitt lymphoma cells.Proc.Natl.Acad.Sci.USA81, 7632–7636 (1982).
Damania B., Choi Joong-Kook, Jung J.U.: Signaling activities of gamma herpesvirus membrane proteins.J.Virol.74, 1593–1601 (2000).
Desrosiers R.C., Sasseville V.G., Czajak S.C., Zhang X., Mansfield K.G., Kaur A., Johnson R.P., Lackner A.A., Jung J.U.: A herpesvirus of rhesus monkeys related to the human Kaposi’s sarcoma-associated herpesvirus.J.Virol.71, 9764–9769 (1997).
Dittmer D., Lagunoff M., Renne R., Staskus K., Haase A., Ganem D.: A cluster of latently expressed genes in Kaposi’s sarcoma-associated herpesvirus.J.Virol.72, 8309–8315 (1998).
Dupin N., Fisher C., Kellam P., Ariad S., Tulliez M., Franck N., Van Marck E., Salmon D., Gorin I., Escande J.P., Weiss R.A., Alitalo K., Boshoff C.: Distribution of HHV-8 positive cells in Kaposi’s sarcoma, multicentric Castleman’s disease and primary effusion lymphoma.Proc.Nat.Acad.Sci.USA96, 4546–4551 (1999).
Dupin N., Diss T., Kellam P., Tulliez M., Du M.Q., Weiss R.A., Isaacson P.G., Boshoff C.: HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8 positive plasmablastic lymphoma.Blood95, 1406–1412 (2000).
van Dyk L.F., Hess J.L., Katz J.D., Jakoby M., Speck S.H., Virgin H.W. IV: The murine gamma herpesvirus 68 vCyclin is an oncogene that promotes cell cycle progression in primary lymphocytes.J.Virol.73, 5119–5122 (1999).
Efstathiou S., Ho M., Hall S., Styles C.J., Scott S.D., Gompels U.A.: Murine herpesvirus 68 is genetically related to the gamma herpesviruses Epstein-Barr virus and herpesvirus saimiri.J.Gen.Virol.71, 1365–1372 (1990).
Eliopoulos A.G., Blake S.M., Floetmann J.E., Rowe M., Young L.S.: Epstein-Barr virus encoded latent membrane protein 1 activates the JNK pathway through extreme C-terminusvia a mechanism involving TRADD and TRAF2.J.Virol.73, 1023–1035 (1999).
Ellis M., Chew Y.P., Fallis L.: Degradation of p27KIP cdk inhibitor triggered by Kaposi’s sarcoma virus cyclin-cdk6 complex.EMBO J.18, 644–653 (1999).
Ensoli B., Buonaguro L., Barrilari G., Fiorelli V., Gendelman R., Morgan R.A., Wingfield P., Gallo R.C.: Release, uptake and effects of extracellular HIV-Tat protein in induction of Kaposi’s sarcoma.J.Virol.67, 277–287 (1993).
Ensoli B., Sturzl M., Monini P.: Cytokine-mediated growth promotion of Kaposi’s sarcoma and primary effusion lymphoma.Cancer Biol.10, 367–381 (2000).
Ensser A., Pflanz R., Fleckenstein B.: Primary structure of the alcephaline herpesvirus 1 genome.J.Virol.71, 6517–6525 (1997).
Ernberg I., Falk K., Minarovits J.: The role of methylation in the phenotype dependent modulation of Epstein-Barr nuclear antigen 2 and latent membrane protein genes in cells latently infected with Epstein-Barr virus.J.Gen.Virol.70, 2989–3002 (1989).
Falk L., Deinhardt F., Nonoyama M., Wolfe L.G., Bergholz C.: Properties of a baboon lymphotropic herpesvirus related to Epstein-Barr virus.Internat.J.Cancer18, 798–807 (1976).
Farrell P.J.: Epstein-Barr virus, pp. 120–133 in S.J. O’Brien (Ed.):Genetic Maps. Cold Springer Harbor Press, New York 1992.
Feederle R., Kost M., Baumann M., Janz A., Hammerschmidt W., Delecluse H.-J.: The Epstein-Barr virus lytic program is controlled by the cooperative functions of two transactivators.EMBO J.19, 3080–3089 (2000).
Flint S.J., Enquist L.W., Krug R.M., Racaniello V.R., Skalka A.M.: The transcriptional cascades of DNA viruses, pp. 261–276 inPrinciples of Virology. Molecular Biology, Pathogenesis and Control. ASM Press, Washington (DC) 2000.
Friborg J., Kong W., Hottiger M.O., Nabel G.J.: p53 inhibition by the LANA protein of KSHV protects against cell death.Nature402, 889–894 (1999).
Friedman-Kien A.: Disseminated Kaposi’s sarcoma syndrome in young homosexual men.J.Am.Acad.Dermatol.5, 468–471 (1981).
Frizzera G., Massarelli G., Banks P.M., Rosai J.: A systemic lymphoproliferative disorder with morphologic features of Castleman disease.Am.J.Surg.Pathol.7, 211–231 (1983).
Gahn T.A., Schildkraut C.L.: The Epstein-Barr virus origin of plasmid replication,oriP, contains both the initiation and termination sites of DNA replication.Cell58, 527–535 (1989).
Gao S.J., Boshoff C., Jayachandra S., Weiss R.A., Chang Y., Moore P.S.: KSHV ORF K9 (vIRF) is an oncogene that inhibits the interferon signaling pathway.Oncogene15, 1979–1986 (1997).
Gerber P., Nonoyama M., Lucas S., Perlin E., Goldstein L.I.: Oral excretion of Epstein-Barr virus by healthy subjects and patients with infectious mononucleosis.Lancet2, 988–989 (1972).
Gilligan K., Sato H., Rajadurai P., Busson P., Young L.S., Rickinson A.L., Tursz T., Raab-Traub N.: Novel transcription from the Epstein-Barr virus terminalEcoRI fragment,DIJhet, in nasopharyngeal carcinoma.J.Virol.64, 4948–4956 (1990).
Gires O., Zimber-Strobl U., Gonnella R., Ueffing M., Marschall G., Zridler R., Pich D., Hammerschmidt W.: Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule.EMBO J.16, 6131–6140 (1997).
Glickman J., Howe G., Steitz J.: Structural analyses of EBER1 and EBER2 ribonucleoprotein particles present in EBV infected cells.J.Virol.62, 902–911 (1988).
Gompels U.A., Nicholas J., Lawrence G.: The DNA sequence of human herpesvirus 6: structure, coding content and genome evolution.Virology209, 29–51 (1995).
Goodman R.H., Smolik S.: CPB/p300 in cell growth, transformation and development.Genes Dev.14, 1553–1577 (2000).
Gregory C.D., Edwards C.F., Milner A., Wiels J., Lipinski M., Rowe M., Tursy T., Rickinson A.B.: Isolation of a normal B cell subset with a Burkitt-like phenotype and transformationin vitro with Epstein-Barr virus.Internat.J.Cancer42, 213–220 (1988).
Grundhoff A., Ganem D.: Mechanisms governing expression of the vFLIP gene of Kaposi’s sarcoma-associated herpesvirus.J.Virol.75, 1857–1863 (2001).
Haan K.M., Kwok W.W., Longnecker R., Speck P.: Epstein-Barr virus entry utilizing HLA-DP DR or DQ cofactors.J.Virol.74, 2451–2454 (2000).
Henle W., Diehl V., Kohn G., zur Hausen H., Henle G.: Herpes type virus and chromosome marker in normal leukocytes after growth with irradiated Burkitt cells.Science157, 1064–1065 (1967).
Herbst H., Stein H., Niedobitek G.: Epstein-Barr virus and CD30 — malignant lymphomas.Crit.Rev.Oncogen.4, 191–239 (1991).
Hsu H., Xion J., Goeddel D.V.: The TNF receptor 1-associated protein TRADD signals cell death and vF-κB activation.Cell81, 495–504 (1995).
Husain S.M., Usherwood E.J., Dyson H., Coleclough C., Coppola D.L., Woodland M.A., Blackman J.P., Stewart J.P., Sample J.T.: Murine gamma herpesvirus M2 gene is latency associated and its protein is a target for CD8 T lymphocytes.Proc.Nat.Acad.Sci.USA96, 7508–7513 (1999).
Inoue N., Dambough T.R., Rapp J.C.: Alpha herpesvirus origin-binding protein homologue encoded by human herpesvirus 6B, a beta herpesvirus, binds to nucleotide sequences that are similar toori regions of alpha herpesviruses.J.Virol.68, 4126–4136 (1994).
Izumi K.M., Kieff E.D.: The Epstein-Barr virus oncogenic product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-κB.Proc.Nat.Acad.Sci.USA94, 12592–12597 (1997).
Jacoby M.A., Virgin H.W., Speck S.H.: Disruption of the M2 gene of murine gamma herpesvirus 68 alters splenic latency following intranasal, but not intraperitoneal, inoculation.J.Virol.76, 1790–1801 (2002).
Jansson A., Masucci M., Rymo L.: Methylation of discrete sites within the enhancer region regulates the activity of the Epstein-Barr virusBamHI W promoter region in Burkitt lymphoma lines.J.Virol.66, 62–69 (1992).
Kasolo F.C., Monze M., Obel N., Anderson R.A., French C., Gompels U.A.: Sequence analyses of human herpesvirus 8 strains from both African human immunodeficiency virus-negative and -positive childhood endemic Kaposi’s sarcoma show a close relationship with strains identified in febrile children and variation in the K1 glycoprotein.J.Gen.Virol.79, 3055–3065 (1998).
Katano H., Sato Y., Kurata T., Mori S.H., Sata T.: Expression and localization of human herpesvirus 8-encoded proteins in primary effusion lymphoma, Kaposi’s sarcoma and multicentric Castleman disease.Virology269, 335–344 (2000).
Kedes D.H., Lagunoff M., Renne R., Ganem D.: Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi’s sarcoma-associated herpesvirus.J.Clin.Invest.100, 2602–2610 (1997).
Kennedy M.M., Biddolph S., Lucas S.B., Howels D.D., Picton S., McGee J.O.D., Silva I., Uhlman V., Luttich K., Leary J.J.: Cyclin D1 expression and HHV8 in Kaposi’s sarcoma.J.Clin.Pathol.52, 569–573 (1999).
Kerr B.M., Lear A.L., Rowe M., Croom-Carter D., Young L.S., Rookes S.M., Gallimore P.H., Rickinson A.B.: Three transcriptionally distinct forms of Epstein-Barr virus latency in somatic cell hybrids: cell phenotype dependence of promoter virus usage.Virology187, 189–201 (1992).
Kieff E.: Epstein-Barr virus and its replication, pp. 2343–2396 in B.N. Fields, D.M. Knipe, P.M. Howley (Eds):Field’s Virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia-New York-London-Hong Kong-Tokyo 1996.
Kim A.L., Maher M., Hayman J.B.: An imperfect correlation between DNA replication activity of Epstein Barr virus nuclear antigen and binding to the nuclear import receptor, Rch/importin alpha.Virology239, 340–351 (1997).
Kledal T.N., Rosenkilde M.M., Coulin F., Simmons G., Johnsen A.H., Alouani S., Power C.A., Luttichau H.R., Gerstoft J., Clapham P.R., Clark-Lewis I., Wells T.N., Schwartz T.W.: A broad spectrum chemokine antagonist encoded by Kaposi’s sarcoma associated herpesvirus.Science277, 1656–1659 (1997).
Klein G., Purtilo D.: Summary: symposium on Epstein-Barr virus induced lymphoproliferative diseases in immunodeficient patients.Cancer Res.41, 4302–4304 (1981).
Krysan P.J., Haase S.B., Calos M.B.: Isolation of human sequences that replicate autonomously in human cells.Mol.Cell.Biol.9, 1026–1033 (1989).
Lagunoff M., Ganem D.: The structure and coding organization of the genomic termini of Kaposi’s sarcoma-associated herpesvirus.Virology236, 147–154 (1997).
Lagunoff M.R., Majett R., Weiss A., Ganem D.: Deregulated signal transduction by the K1 gene product of Kaposi’s sarcoma-associated herpesvirus.Proc.Nat.Acad.Sci.USA96, 5704–5709 (1999).
Lee H., Gun J., Li M., Choi J.K., DeMaria M., Rosenyweig M., Jung J.U.: Identification of an immunoreceptor tyrosine-based activation motif of K1 transforming protein of Kaposi’s sarcoma-associated herpesvirus.Mol.Cell.Biol.18, 5219–5228 (1998a).
Lee H., Veazey R., Williams K., Li M., Guo J., Neipel F., Fleckensteinm B., Lackner A., Desrosiers R.C., Jung J.U.: Deregulation of cell growth by the K1 gene of Kaposi’s sarcoma-associated herpesvirus.Nature Med.4, 435–440 (1998b).
Leight E.R., Sugden B.: EBNA1: a protein pivotal to latent infection by Epstein-Barr virus.Rev.Med.Virol.10, 83–100 (2000).
Li Q.X., Young L.S., Niedobitek G., Dawson C.W., Birkenbach M., Wang F., Rickinson A.B.: Epstein-Barr virus infection and replication in human epithelial cell system.Nature356, 347–350 (1992).
Lu S.-J., Day N.E., Gegos L.: Linkage of nasopharyngeal carcinoma subseptibility locus to the HLA region.Nature346, 470–471 (1990).
Lubyova B., Pitha P.M.: Characterization of a novel human herpesvirus 8-encoded protein, vIRF3, that shows homology to viral and cellular interferon regulatory factors.J.Virol.74, 8194–8201 (2000).
Mackey D., Sugden B.: The linking regions of EBNA1 are essential for its support of replication and transcription.Mol.Cell.Biol.19, 3349–3359 (1999).
Magrath I.: The pathogenesis of Burkitt’s lymphoma.Adv.Cancer Res.55, 133–269 (1990).
Magrath I., Jain V., Bhatia K.: Epstein-Barr virus and Burkitt’s lymphoma.Semin.Cancer Biol.3, 285–295 (1992).
Mann D.J., Child E.S., Swanton C., Laman H., Jones N.: Modulation of p27/KIP levels by the cyclin encoded by Kaposi’s sarcomaassociated herpesvirus.EMBO J.18, 654–663 (1999).
Manning A.M.: Small molecule regulators of AP-1 and NF-κB, pp. 39–52 in G.L. Letts, D.W. Morgan (Eds):Inflammatory Process: Molecular Mechanisms and Therapeutic Opportunities. Birkhauser, Basel-Boston-Berlin 2000.
Masood R., Cai J., Zheng T., Smith D.L., Naidu Y., Gill P.C.: Vascular endothelial growth factor — vascular permeability factor is an autocrine growth factor for AIDS-Kaposi’s sarcoma.Proc.Nat.Acad.Sci.USA94, 979–984 (1997).
Medveczky M.M., Geck P., Clarke C., Byrnes J., Sullivan J.L., Medveczky P.G.: Arrangement of repetitive sequences in the genome of herpesvirus sylvilagus.J.Virol.63, 1010–1014 (1989).
Middleton T., Sugden B.: Retention of plasmid DNA in mammalian cells is enhanced by binding of the Epsten-Barr virus replication protein FBNA1.J.Virol.68, 4067–4071 (1994).
Mistríková J., Remeňová A., Leššo J., Stančeková M.: Replication and persistence of murine herpesvirus 72 in lymphatic system and peritoneal blood mononuclear cells of Balb/c mice.Acta Virol.38, 151–156 (1994).
Mistríková J., Mrmusova M.: Detection of abnormal lymphocytes in the blood of Balb/c mice infected with murine herpesvirus strain 72.Acta Virol.42, 79–82 (1998).
Mistríková J., Mrmusova M., Ďurmanová V., Rajčani J.: Increased neoplasm development due to immunosuppressive treatment with FK506 in Balb/c mice persistently infected with mouse herpesvirus.Viral Immunol.12, 237–247 (1999).
Mistríková J., Rašlová H., Mrmusová M., Kúdelová M.: A murine gamma herpesvirus — review.Acta Virol.44, 211–226 (2000).
Mittnacht S., Boshoff C.: Viral cyclins.Rev.Med.Virol.10, 175–184 (2000).
Molden J., Chang Y., You Y., Moore P.S., Goldsmith M.A.: A Kaposi’s sarcoma-associated herpesvirus-encoded cytokine homologue (vIL-6) activates signaling through the shared gp130 receptor subunit.J.Biol.Chem.272, 19625–19631 (1997).
Molesworth S.J., Lake C.M., Borza C.M., Turk S.M., Hutt-Fletcher L.M.: Epstein-Barr virus gH is essential for penetration of B cells, but also plays a role in attachment of virus to epithelial cells.J.Virol.74, 6324–6332 (2000).
Moore P.S., Chang Y.: Molecular virology of Kaposi’s sarcoma-associated herpesvirus.Phil.Trans.Roy.Soc.London B356, 499–516 (2001).
Motokura T., Bloom T., Kim H.G., Juppner H., Ruderman J.V., Kronenberg H.M., Arnold A.: A novel cyclin encoded by abcl-1 linked candidate oncogene.Nature350, 512–525 (1991).
Mrmusová M., Horváthová M., Klobušická M., Mistríková J.: Immunotyping of leukocytes in peripheral blood of Balb/c mice infected with mouse herpesvirus isolate 72.Acta Virol.46, 19–24 (2002).
Muralidhar S., Pumpery A.M., Hassani M., Sadaie M.R., Azumi N., Kishishita M., Brady J.N., Doniger J., Medveczky P., Rosenthal L.J.: Identification of kaposin open reading frame K12 as a human herpesvirus 8 (Kaposi’s sarcoma-associated herpesvirus) transforming gene.J.Virol.72, 4980–4988 (1998).
Neipel F., Albrecht J.C., Ensser A., Huang Y.Q., Li J.J., Friedman K.A., Fleckenstein B.: Human herpesvirus 8 encodes a homologue of macrophage inhibitory protein-1 and interleukin-6.J.Virol.71, 839–842 (1997).
Nelson P.J., Krenski A.M.: Chemokines, lymphocytes and viruses: what goes around comes around.Curr.Opin.Immunol.10, 265–270 (1998).
Nemerow G.R., Wolfert R., McNaughton M.E., Cooper N.R.: Identification and characterization of the Epstein-Barr virus receptor on human B lymphocytes and its relationship to the C3d complement receptor (CR2).J.Virol.55, 347–351 (1985).
Nicholas J.: Evolationary aspects of oncogenic herpesviruses.J.Clin.Pathol.Mol.Pathol.53, 222–237 (2000).
Nicholas J., Ruvolo V.R., Burns W.H., Sandford G., Wan X., Giufo D., Hendrickson S.B., Guo H.G., Hayward G.S., Reitz M.S.: Kaposi’s sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein 1 and interleukin-6.Nature Med.3, 287–292 (1997).
Niedobitek G., Young L.S., Sam C.K., Brooks L., Prasad U., Rickinson A.B.: Expression of Epstein-Barr virus genes and of lymphocyte activation molecules in undifferentiated nasopharyngeal carcinomas.Am.J.Pathol.140, 879–887 (1992).
Nishi J., Maruyama I.: Increased expression of vascular endothelial growth factor (VEGF) in Castleman disease: proposed pathomechanism for vascular proliferation in the affected lymph node.Leuk.Lymphoma38, 387–394 (2000).
Nishikura K., Ar-Rushidi A., Eriksson J., Watt R., Rovera G., Croce C.M.: Differential expression of the normalamd of the translocated humanc-myc oncogenes in B cells.Proc.Nat.Acad.Sci.USA80, 291–296 (1983).
O’Connor G., Davies N.: Malignant tumors in African children with special reference to malignant lymphomas.J.Pediatr.56, 526–535 (1960).
Ojala P.M., Tianinen M., Salven P., Veikkola T., Castanos-Velez E., Sarid R., Biberfeld P., Makela T.P.: Kaposi’s sarcomaassociated herpesvirus encoded vCyclin dependent kinase 6.Cancer Res.59, 4984–4989 (1999).
Palestro G., Turrini F., Pagano M., Chiusa L.: Castleman disease.Adv.Clin.Path.3, 11–22 (1999).
Pallesen G., Hamilton-Dutoit S.J., Rowe M., Young L.S.: Expression of Epstein-Barr virus latent gene products in tumor cells of Hodgkin’s disease.Lancet337, 329–332 (1991).
Parry C.M., Simas J.P., Smith C.A., Stewart A.C., Minson C.A., Efstathiou S., Alcami A.: A broad spectrum secreted chemokine binding protein encoded by a herpesvirus.J.Exp.Med.191, 573–578 (2000).
Pederson C., Gerstoft J., Lundgren J.D.: HIV-associated lymphoma: histopathology and association with Epstein Barr virus genome related to clinical, immunological and prognostic features.Eur.J.Cancer27, 1416–1423 (1991).
Phelan A., Clements J.B.: Posttranscriptional regulation in herpes simplex virus.Semin.Virol.8, 309–318 (1998).
Polson A.G., Huang L., Likac D.M., Blethrow J.D., Morgan D.O., Burlingame A.L., Ganem D.: Kaposi’s sarcoma associated herpesvirus K-bZIP protein is phosphorylated by cyclin-dependent kinases.J.Virol.75, 3175–3184 (2001).
Pope J.H., Horne M.K., Scott W.: Transformation of fetal human leukocytesin vitro by filtrates of human leukemic cell line containing herpes-like virus.Internat.J.Cancer3, 857–866 (1968).
Ragoczy T., Miller G.: Role of Epstein-Barr virus Rta protein in activation of distinct classes of viral lytic cycle genes.J.Virol.73, 9858–9866 (1999).
Rajčáni J., Blaškovič D., Svobodová J., Čiampor F., Hučková D., Staneková D.: Pathogenesis of acute and persistent murine herpesvirus infection in mice.Acta Virol.29, 51–60 (1985).
Rajčáni J., Bustamante de Contreras L.R., Svobodová J.: Corneal inoculation of murine herpesvirus in mice: the absence of neural spread.Acta Virol.31, 25–30 (1986).
Rašlová H., Mistriková J., Kúdelová M., Mishal Z., Sarasin A., Blangy D., Berebbi M.: Immunophenotypic study of atypical lymphocytes generated in peripheral blood and spleen of nude mice after MHV-72 infection.Viral Immunol.13, 313–327 (2000).
Rašlová H., Berebbi M., Rajčáni J., Sarasin A., Matis J., Kúdelová M.: Susceptibility of mouse mammary glands to murine gamma herpesvirus 72 (MHV-72) infection: evidence of MHV-72 transmissionvia breast milk.Microb.Pathogen.31, 47–58 (2001).
Rawlings D.R., Milman G., Hayward S.D., Hayward G.S.: Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNAI) to clustered sites in the plasmid maintenance region.Cell42, 859–868 (1985).
van Regenmortel M.H.V., Fauquet C.M., Bishop D.H.L.: Herpesvirus family, pp. 220–226 inVirus Taxonomy: Classification and Nomenclature of Viruses. 7th ICTV Report. Academic Press, San Diego 2000.
Rickinson A.B., Kieff E.: Epstein-Barr virus, pp. 2397–2446 in B.N. Fields, D.M. Knipe, P.M. Howley (Eds):Fields’ Virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia-New York-London-Hong Kong-Tokyo 1996.
Rochford R., Lutzke M.L., Alfinito R.S., Clavo A., Cardin R.D.: Kinetics of murine gamma herpesvirus 68 gene expression following infection of murine cells in culture and in mice.J.Virol.75, 4955–4963 (2001).
Rosdahl L., Larsen S.O., Clemmensen J.: Hodgkin’s disease in patients with previous infectious mononucleosis; 30 years experience.Brit.Med.J.2, 253–256 (1974).
Roy D.J., Ebrahimi B.C., Dutia B.M., Nash A.A., Stewart J.P.: Murine gamma herpesvirus M11 gene product inhibits apoptosis and is expressed during virus persistence.Arch.Virol.145, 2411–2420 (2000).
Russo J.J., Bohenzky R.A., Chien M.C., Chen J., Yan M., Maddalena D., Parry J.P., Peruzzi D., Edelman I.S., Chang Y., Moore P.S.: Nucleotide sequence of the Kaposi’s sarcoma-associated herpesvirus (HHV8).Proc.Nat.Acad.Sci.USA93, 14862–14867 (1996).
Samaniego F., Markham P., Gallo R.C., Ensoli B.: Inflammatory cytokines induce AIDS-Kaposi’s sarcoma like lesion formation in nude mice.J.Immunol.154, 3582–3592 (1995).
Sample J., Brooks L., Sample C.: Restricted Epstein-Barr virus protein expression in Burkitt lymphoma is due to a different Epstein-Barr nuclear antigen I transcriptional site.Proc.Nat.Acad.Sci.USA88, 6343–6347 (1991).
Sarawar S.R., Lee B.J., Anderson M., Teng Y.C., Zuberi R., von Gejsen S.: Chemokine induction and leukocyte trafficking to the lungs during murine gamma herpesvirus 68 (MHV-68) infection.Virology293, 54–62 (2002).
Schultz T.F.: Kaposi’s sarcoma-associated herpesvirus (human herpesvirus 8): epidemiology and pathogenesis.Antimicrob.Chemother.45 (Suppl.), 15–27 (2000).
Sen P., Baltimore D.: Multiple nuclear factors interact with the immunoglobin enhancer sequences.Cell46, 705–716 (1986).
Sharp T.V., Boshoff C.: Kaposi’s sarcoma associated herpesvirus: from cell biology to pathogenesis.Life49, 97–104 (2000).
Sharp T.V., Wang H.W., Kuomi A., Hollyman D., Endo Y., Ye H., Du M.Q., Boshoff C.: K15 protein of Kaposi’s sarcomaassociated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function.J.Virol.76, 802–806 (2002).
Smith P.R., Griffin B.E.: Transcription of the Epstein-Barr virus gene EBNA1 from different promoters in nasopharyngeal carcinoma and B lymphoblastoid cells.J.Virol.66, 706–714 (1992).
Song H.Y., Regnier C.H., Kirschning C.J., Goeddel D.V., Rothe M.: Tumor necrosis factor (TNF) mediated cascades: bifurcation of nuclear factor κB and c-jun N-terminal kinase (JNK/SAPK) pathways at the TNF receptor associated factor 2.Proc.Nat.Acad.Sci.USA94, 9792–9796 (1997).
Song M.J., Brown H.J., Wu T.-T., Sun R.: Transcription activation of polyadenylated nuclear RNA by Rta in human herpesvirus-8/Kaposi’s sarcoma-associated herpesvirus.J.Virol.75, 3129–3140 (2001).
Speck P., Haan K.M., Longnecker R.: Epstein-Barr virus entry into cells.Virology277, 1–5 (2000).
Speck S.H., Chatila T., Flemington E.: Reactivation of Epstein-Barr virus: regulation and function of the BZLF1 gene.Trends Microbiol.5, 399–405 (1997).
Staskus K.A., Zhong W., Gebhard K., Herndier B., Wang H., Renne R., Beneke J., Pudney J., Anderson D.J., Ganem D., Haase A.T.: Kaposi’s sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells.J.Virol.71, 715–19 (1997).
Stevenson P.G., Doherty P.C.: Kinetic analysis of the specific host response to a murine gamma herpesvirus.J.Virol.72, 943–949 (1998).
Stevenson P.G., Efstathiou S., Doherty P.C., Lehner P.J.: Inhibition of MHC class I-restricted by gamma 2 herpesviruses.Proc.Nat.Acad.Sci.USA97, 8455–8460 (2000).
Stewart J.P., Esuewood E.J., Ross A., Dyson H., Nash T.: Lung epithelial cells are a major site of murine gamma herpesvirus persistence.J.Exp.Med.187, 1941–1951 (1998).
Stine J.T., Wood C., Hill M., Epp A., Raport C.J., Schweickart V.L., Endo Y., Sasaki T., Simmons G., Boshoff C., Clapham P., Chang Y., Moore P., Gray P.W., Chantry D.: KSHV encoded CC chemokine vMIPIII is a CCR4 agonist, stimulates angiogenesis and selectively chemoattract TH2 cells.Blood95, 1151–1157 (2000).
Sunil-Chandra N.P., Efstathiou S., Arno J., Nash A.A.: Virological and pathological features of mice with murine gamma herpesvirus.J.Gen.Virol.73, 2347–2356 (1992a).
Sunil-Chandra N.P., Efstathiou S., Arno J., Nash A.A.: Murine gamma herpesvirus establishes a latent infection in mouse B lymphocytesin vivo.J.Gen.Virol.73, 3275–3279 (1992b).
Sunil-Chandra N.P., Fazakerley A.J., Nash A.A.: Lymphoproliferative disease in mice infected with murine gamma herpesvirus 68.Am.J.Pathol.145, 818–826 (1994).
Svobodová J., Blaškovič D., Mistríková J.: Growth characteristics of herpesviruses isolated from free living small rodents.Acta Virol.26, 256–263 (1982).
Swanton C., Mann D.J., Fleckenstein B., Neipel F., Peters G., Jones N.: Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins.Nature390, 187–187 (1997).
Taniguchi M., Lamphier M.S., Tanaka N.: IRF-1: the transcription factor linking the interferon response and oncogenesis.Biochim.Biophys.Acta1333, M9-M17 (1997).
Telford E.A.R., Watson M.S., Aird H.C., Perry J., Davison A.J.: The DNA sequence of equine herpesvirus 2.J.Mol.Biol.249, 520–528 (1995).
Terry L.A., Stewart J.P., Nash A.A., Fazakerly J.K.: Murine gamma herpesvirus-68 infection of and persistence in the central nervous system.J.Gen.Virol.81, 2535–2543 (2000).
Thome M., Schneider P., Hofmann K., Fickenscher H., Meinl E., Neipel F., Mattmann C., Burns K., Bodmer J.L., Schroter M., Scaffidi C., Krammer P.H., Peter M.E., Tschopp J.: Viral FLICE-inhibitory proteins (vFLIPs) prevent apoptosis induced by death receptors.Nature386, 517–521 (1997).
Thomson B.J., Efstathiou S., Honess R.W.: Acquisition of the human adeno-associated virus type 2rep gene by human herpesvirus 6.Nature351, 78–80 (1991).
Tierney R.J., Steven N., Young L.S., Rickinson A.B.: Epstein-Barr virus latency in blood mononuclear cells: analysis of viral gene transcription during primary infection and in the carrier state.J.Virol.68, 7374–7385 (1994).
Tokai N., Fujimoto N.A., Toyoshima Y.: Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle.EMBO J.15, 457–467 (1996).
Usherwood E.J., Ross A.J., Allen D.J., Nash A.A.: Murine gamma herpevirus-induced splenomegaly: a critical role for CD4 T cells.J.Gen.Virol. 77, 627–630 (1996).
Vilcek J., Sen G.C.: Interferons and other cytokins, pp. 375–399 in B.N. Fields, D.M. Knipe, P.M. Howley (Eds):Fields ‘Virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia 1996.
Virgin H.W. IV,Latreille P., Wamsley P., Hallsworth K., Weck K.E., Dal Canto A.J., Speck H.S.: Complete sequence and genomic analysis of murine gamma herpesvirus 68.J.Virol.71, 5894–5904 (1997).
Virgin H.W. IV,Presti R.M., Li X.Y., Liu C., Speck S.H.: Three distinct regions of the murine gamma herpesvirus 68 genome are transcriptionally active in latently infected mice.J.Virol.73, 2321–2332 (1999).
Wakeling M.N., Roy D.J., Nash A.A., Stewart J.P.: Characterization of the murine gamma herpesvirus ORF74 product: a novel oncogenic G protein-coupled receptor.J.Gen.Virol.82, 1187–1197 (2001).
Wang X., Kenyon W.J., Li Q., Mullberg J., Hutt-Fletcher L.M.: Epstein-Barr virus uses different complexes of glycoproteins gH and gL to infect B lymphocytes and epithelial cells.J.Virol.72, 5552–5558 (1998).
Wang S., Lui S., Wu M., Geng Y., Wood C.: Kaposi’s sarcoma-associated herpesvirus — human herpesvirus-8 ORF50 gene product contains a potent C-terminal activation domain which activates gene expressionvia a specific target sequence.Arch.Virol.146, 1415–1426 (2001).
Weck K.E., Barkon M.L., Yoo L.I., Sfeck H., Virgin H.W. IV: Mature B cells are required for acute splenic infection, but not for establishment of latency by murine gamma herpesvirus.J.Virol.70, 6775–6780 (1996).J.Virol. 70, 6775—6780 (1996).
Weck K.E., Kim S.S., Virgin H.W. IV,Speck S.: Macrophages are the major reservoir of latent murine gamma herpesvirus 68 in peritoneal cells.J.Virol.73, 3273–3283 (1999).
Whitby D., Howard M., Tenant-Flowers M., Brink N., Copas A., Boshoff C., Hatzioannou T., Suggett F., Aldam D., Denton A., Miller R., Weller I., Weiss R., Tedder R., Schultz T.: Detection of Kaposi’s sarcoma-associated herpesvirus in peripheral blood of HIV-infected individuals as progression to Kaposi’s sarcoma.Lancet346, 799–802 (1995).
Yao Q.Y., Rickinson A.B., Epstein M.A.: A re-examination of the Epstein-Barr virus carrier state in healthy seropositive individuals.Internat.J.Cancer35, 35–42 (1985).
Yates J.L., Warren N., Sugden B.A.: Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells.Nature313, 812–815 (1985).
Zalani S., Holley-Guthrie E., Kenney S.: Epstein-Barr viral latency is disrupted by the immediate early BRLF1 protein through a cell-specific mechanism.Proc.Nat.Acad.Sci.USA93, 9194–9199 (1996).
Zhang S., Nonoyama M.: The cellular proteins that bind specifically to the Epstein-Barr virus belong to a family of plasmid DNA replication origin.Proc.Nat.Acad.Sci.USA91, 2843–2847 (1994).
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Rajčáni, J., Kúdelová, M. Gamma herpesviruses: Pathogenesis of infection and cell signaling. Folia Microbiol 48, 291–318 (2003). https://doi.org/10.1007/BF02931360
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DOI: https://doi.org/10.1007/BF02931360