Abstract
The effects of 41 benzothiazolium salts onEuglena gracilis were characterized with regard to the influence on growth and on chlorophyll synthesis, and to their ability to induce permanent loss of chloroplasts. Some salts induced white mutants ofE. gracilis (the first benzothiazole derivatives with this activity). The relationship between the biological effect and chemical structure was confirmed and expressed quantitatively by means of Free - Wilson and Fujita -Ban analysis.
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Arnon D.: Copper enzymes in isolated chloroplasts. Polyphenoloxidase inBeta vulgaris.Plant Physiol. 24, 1–7 (1949).
Cramer M., Myers J.: Growth and photosynthetic characteristics ofEuglena gracilis.Arch. Mikrobiol. 17, 348–402 (1952).
Ebringer L.: Are plastids derived from procaryotic microorganisms? The sensitivity of chloroplasts ofEuglena gracilis.J.Gen.Microbiol. 71, 35–52 (1972).
Ebringer L.: Effects of drugs on chloroplasts, in F.E. Hahn (Ed.):Progress in Molecular and Subcellular Biology, Vol. 6, pp. 271–350. Springer-Verlag, Berlin-Heidelberg-New York 1978.
Ebringer L., Jurášek A., Koníček J., Koníčková M., Lahitová N., Trubačík S.: Mutagenic action of nitrofurans onEuglena gracilis andMycobacterium phlei.Antimicrob.Agents Chemother. 9, 682–689 (1976).
Foltínová P., Ebringer L., Sutoris V.: The effect of some benzthiazol derivatives cnEuglena gracilis.Folia Microbiol. 25, 412–414 (1980).
Foltínová P., Ebringer J., Sodomova J., Sutoris V., Gáplovský A.: Effect of 2-alkyl and 2-arylalkylsulfonylbenzothiazoles onEuglena gracilis. (In Slovak)Biológia (Bratislava) 37, 689–694(1982).
Foltínová P., Sutoris V., Sodomová J., Halgaš J.: The antimicrobial efficiency of benzothia. zolium salts. (In Slovak)Biológia (Bratislava) 38, 671–678 (1983).
Free S.H., Wilson J.W.: A mathematical contribution to structure - activity studies.J.Med. Chem. 7, 395–399 (1964).
Fujita T., Ban T.: Structure — activity study of phenethylamines as substrates of biosynthetic enzymes of sympathetic transmiters.J.Med.Chem. 14, 148–150 (1971).
Halgaš J., Sutoris V., Sekerka V., Foltinova P., Solčániová E.: Benzothiazole compounds. XIX. Synthesis of 3-benzylbenzothiazolium salts, their growth regulation effects, and antimicrobial activities.Chem.Zvesti 37, 663–676 (1983a).
Halgaš J., Sutoris V., Foltínová P., Sekerka V.: Benzothiazole compounds. XX. Synthesis of 3,4,6-substituted benzothiazolium salts as plant growth regulators and their antimicrobial activity.Chem. Zvesti 37, 799–808 (1983b).
Kirk J.T.O.: Effect of streptomycin on greening and biosynthesis inEuglena gracilis.Biochim. Biophys.Acta 56, 139–141 (1962).
Mego J.L.: The effect of hadacidin on chloroplast development in nondividingEuglena cells.Biochim.Biophys.Acta 79, 221–225 (1964).
Negwer M.:Organisch-chemische Arzneimittel und ihre Synonyma (I-III). Akademie Verlag, Berlin 1978.
Sutoris V., Sekerka V., Halgaš J., Bajči P.: Agent increasing the amount of sugars in sugarproducing plants.Czech.Pat.Appl: PV-2928 (1982).
Sutoris V., Halgaš J., Sekerka V., Foltínová P., Gáplovský A.: Benzothiazole compounds. XVIII. Preparation of benzothiazolium salts, their growth regulation effects, and antimicrobial activities.Chem. Zvesti 37, 653–662 (1983).
Sutoris, V., Halgaš J., Foltínová P., Sekerka V.: Benzothiazole compounds. XXII. Synthesis of 3- and 2,3-substituted benzothiazolium salts, investigation of their antimicrobial and growthregulating activity.Chem.Zvesti 38, 247–253 (1984).
Sutoris V., Sekerka V., Halgaš J.: Agent with stimulatory effects based on 2-R-3-R1-substituted benzothiazolium salts.Czech.Pat. 225–008 (1985).
Vrbovský L., Horakova K., Navarová J., Veber P., Ebringer L.: The study of correlation betweenin vivo andin vitro toxicity.Proc.Eur.Soc.Tox. 16, 236–241 (1975).
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Foltínová, P., Ebringer, L., Sutoris, V. et al. Benzothiazolium salts—relationships between their structure, toxicity and effect on the plastid system ofEuglena gracilis . Folia Microbiol 31, 319–328 (1986). https://doi.org/10.1007/BF02926958
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DOI: https://doi.org/10.1007/BF02926958