Abstract
The effect of certain inorganic and coordinated nickel compounds on the resistance to different destructive substances, rheological properties, and functional activity of healthy human red blood cells (RBC), was investigated. It is shown that nickel compounds affect the erythrocyte membrane lipid bilayer, as well as membrane proteins to various extents, depending on the type of compounds used. In general, the acceleration of erythrocyte aging was observed to be more pronounced in young erythrocytes. The observed results suggest that nickel compounds decrease water permeability across erythrocyte membranes. Almost all the investigated nickel compounds decrease erythrocyte thermostability, deformability, and the rate of O2 release by erythrocytes.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
F. W. Sunderman, Jr.,Fed. Proc. 37, 40 (1978).
F. W. Sunderman, Jr.,Biol. Trace Element Res. 1, 63 (1978).
F. W. Sunderman, Jr.,Environ. Health Perspect. 40, 63 (1978).
M. Costa,Cancer Bull. 36, 247 (1980).
M. Costa and J. P. Heck,Advances in Inorganic Biochemistry, vol. 6, G. L. Eichhorn and L. Marzilli, eds., Springer-Verlag, 1984, p. 285.
E. A. Guliayev, and A. V. Aronova,Prob. Hematol. Blood Transfus. 9, 56 (1972).
G. Jasmin,Clin. Res. 21, 1068 (1973).
E. E. Morse, T. Y. Lee, R. F. Reiss, and F. W. Sunderman, Jr.,Ann. Clin. Lab. Sci. 7, 171 (1977).
A. Oskarsson, and F. W. Sunderman, Jr.,Ann. Clin. Lab. Sci. 11, 165 (1984).
A. Schnegg and M. Kirchgessner,Nickel, M. Anke, ed., VEB Kongress und Werbedruck Oberlungwitz, GDR, 1980, pp. 11–16.
M. Anke, H. Kronemann, B. Groppel, A. Hennig, D. Meissner, and H. J. Schneider,Nickel, M. Anke, ed., VEB Kongress und Werbedruck Oberlungwitz, GDR, 1980, pp. 3–10.
O. V. Krulusauri K. D. Zhakadze, and T. A. Yakovlev,Mat. Sci. Conf. Young Phys. Kutaisi, 1986, p. 18.
E. A. Kovalenko, J. M. Berezovsky, and V. A. Epshtein,Polarographic Determination of O 2 in the Organism, Medicina, Moscow, 1975, pp. 179–199.
P. Teitel,Nouv. Rev. Franc. Hematol. 2, 195 (1967).
M. J. Gregersen, C. A. Bryant, W. E. Hammerle, S. Usami, and S. Chien,Science 157, 825 (1967).
K. S. Trincher, and L. V. Orlova,Biophisika 10, 518 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tkeshelashvili, L.K., Tsakadze, K.J. & Khulusauri, O.V. Effect of some nickel compounds on red blood cell characteristics. Biol Trace Elem Res 21, 337–342 (1989). https://doi.org/10.1007/BF02917273
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02917273