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Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s.Nature 1993; 362: 801–9.
Anderson KM, Wilson PW, Odell PM et al. An updated coronary risk profile. A statement for health professionals.Circulation 1991; 83: 356–62.
Heller RF, Chinn S, Pedoe HD et al. How well can we predict coronary heart disease? Findings in the United Kingdom Heart Disease Prevention Project.Br Med J (Clin Res Ed) 1984; 288: 1409–11.
Macko RF, Ameriso SF, Gruber A et al. Impairments of the protein C system and fibrinolysis in infection-associated stroke.Stroke 1996; 27: 2005–11.
Roivainen M, Viik-Kajander M, Palosuo T et al. Infections, inflammation, and the risk of coronary heart disease.Circulation 2000; 101: 252–7.
Kim JS, Yoon SS, Kim YH et al. Serial measurement of interleukin- 6, transforming growth factor-beta, and S-100 protein in patients with acute stroke.Stroke 1996; 27: 1553–7.
Liu T, McDonnell PC, Young PR et al. Interleukin-1 beta mRNA expression in ischemic rat cortex.Stroke 1993; 24: 1746–50.
Liu T, Clark RK, McDonnell PC et al. Tumor necrosis factor-alpha expression in ischemic neurons.Stroke 1994; 25: 1481–8.
Esmon CT, Taylor FB, Jr, Snow TR. Inflammation and coagulation: linked processes potentially regulated through a common pathway mediated by protein C.Thromb Haemost 1991; 66: 160–5.
Taylor FB, Jr., Chang A, Esmon CT et al. Protein C prevents the coagulopathic and lethal effects ofEscherichia coli infusion in the baboon.J Clin Invest 1987; 79:918–25.
Balding J, Livingstone WJ, Conroy J et al. Inflammatory bowel disease: the role of inflammatory cytokine gene polymorphisms.Mediators Inflamm 2004; 13: 181–7.
Bamford JM, Sandercock PA, Warlow CP et al. Interobserver agreement for the assessment of handicap in stroke patients.Stroke 1989; 20: 828.
Bamford J, Sandercock P, Dennis M et al. Classification and natural history of clinically identifiable subtypes of cerebral infarction.The Lancet 1991; 337: 1521–6.
Rastenyte D, Tuomilehto J, Sarti C. Genetics of stroke — a review.J Neurol Sci 1998; 153: 132–45.
Brass LM, Isaacsohn JL, Merikangas KR et al. A study of twins and stroke.Stroke 1992; 23: 221–3.
Kiely DK, Wolf PA, Cupples LA et al. Familial aggregation of stroke. The Framingham Study.Stroke 1993; 24: 1366–71.
Graffagnino C, Herbstreith MH, Roses AD et al. A molecular genetic study of intracerebral hemorrhage.Arch Neurol 1994; 51: 981–4.
Fishman D, Faulds G, Jeffery R et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene onIL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.J Clin Invest 1998; 102: 1369–76.
Nauck M, Winkelmann BR, Hoffman MM et al. The interleukin-6 G(-174)C promoter polymorphism in the LURIC cohort: no association with plasma interleukin-6, coronary artery disease, and myocardial infarction.J Mol Med 2002; 80: 507–13.
Schluter B, Raufhake C, Erren M et al. Effect of the interleukin-6 promoter polymorphism (-174 G/C) on the incidence and outcome of sepsis.Crit Care Med 2002; 30: 32–7.
Bonafe M, Olivieri F, Cavallone L et al. A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity.Eur J Immunol 2001; 31: 2357–61.
Burzotta F, Iacoviello L, Di Castelnuovo A et al. Relation of the — 174 G/C polymorphism of interleukin-6 to interleukin-6 plasma levels and to length of hospitalisation after surgical coronary revascularization.Am J Cardiol 2001; 88: 1125–8.
Pola R, Gaetani E, Flex A et al. -174 G/C interleukin-6 gene polymorphism and increased risk of multi-infarct dementia: a casecontrol study.Exp Gerontol 2002; 37: 949–55.
Tatlisumak T, Fisher M. Hematologic disorders associated with ischemic stroke.J Neurol Sci 1996; 140: 1–11.
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Balding, J., Livingstone, W., Pittock, S. et al. The IL-6 G-174C polymorphism may be associated with ischaemic stroke in patients without a history of hypertension. Ir J Med Sci 173, 200–203 (2004). https://doi.org/10.1007/BF02914551
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DOI: https://doi.org/10.1007/BF02914551