Summary
Five patients with histiocytic necrotizing lymphadenitis (Kikuchi’s disease) with erythematus or popular skin lesions were studied. All patients healed naturally within a few months like the patients with no skin involvement. Histological findings for the skin lesions mimicked cutaneous malignant lymphoma. The infiltrated mononuclear cells usually demonstrated positive reactions for Ki-M1p (20–63%), lysozymes (13–54%), MT-1 (18–64%), UCHL-1 (22–39%) and LN2 (17–36%). OPD-4 and L26 positive cells were few in number. These results suggest that the infiltrated cells in a Kikuchi’s disease skin lesion are composed of the same components as the affected lesion in the lymph node.
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Sumiyoshi, Y., Kikuchi, M., Takeshita, M. et al. Immunohistological study of skin involvement in Kikuchi’s disease. Virchows Archiv B Cell Pathol 62, 263–269 (1992). https://doi.org/10.1007/BF02899691
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DOI: https://doi.org/10.1007/BF02899691