Abstract
Water extract of dry fruits ofTerminalia chebula (Hindi-Harda, Telugu-Karakkaya) at a dose of 200 mg/kg body weight improved the glucose tolerance as indicated by 44% of reduction in the peak blood glucose at 2nd hour in glucose tolerance test in diabetic (streptozotocin induced) rats. Treatment of diabetic rats with an initial fasting blood glucose of 253±9.4 mg/dl daily once with the water extract (200 mg/kg) for two weeks brought down the fasting blood glucose to 123±8.4 mg/dl which is only slightly above the normal value. These results indicate that water extract of Terminalia chebula improves glucose tolerance and brings down fasting blood glucose in diabetic rats.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Sukhla, R., Shrma, S.B., Prabhu, K.M. and Murthy, P.S. (2000) Medicinal plants for treatment of diabetes mellitus. Ind. J. Clin. Biochem. 15 (Suppl), 169–177.
Indian Council of Medical Research (1976)Medicinal Plants of India, Vol. I.
Indian Council of Medical Research (1987)Medicinal Plants of India, Vol. II.
Rossini, A.A., Like, A.A., Dulin, W.E. and Cahill, G.F. Jr. (1971) Pancreatic β-cell toxicity by streptozotocin anomers. Diabetes 26, 1120–1124.
Babu, B.V., Moorti, R., Pugazhenthi, S., Prabhu, K.M. and Murthy, P.S. (1988) Alloxan recovered rabbits as animal model for screening for hypoglycemic activity of compounds. Ind. J. Biochem. Biophys. 25, 714–718.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Murali, Y.K., Chandra, R. & Murthy, P.S. Antihyperglycemic effect of water extract of dry fruits ofTerminalia chebula in experimental diabetes mellitus. Indian J Clin Biochem 19, 202–204 (2004). https://doi.org/10.1007/BF02894285
Issue Date:
DOI: https://doi.org/10.1007/BF02894285