Summary
HSP60 HSP70 in plasma of 11 cases of Kawasaki diseases (KD) and 23 healthy children were determined. The two groups were controlled for age. Determination of HSP60, HSP70 was conducted in lymphocytes of 14 cases of KD and 26 healthy children. The results were compared with those of 12 patients with febrile diseases and 10 patients with tuberculosis. Our results showed that except a significant difference in plasma HSP70 found between acute phase and convalescent phase of KD (P<0.01), no significant difference was found in HSP60, HSP70 among all groups (P>0.05). The differences in HSP60, HSP70 in lymphocytes were relatively obvious among all groups. The levels of HSP60, HSP70 in acute phase of KD were significantly higher than those in convalescent phase or in healthy controls (P<0.01). The levels of HSP60 in KD were significantly higher than those of patients with febrile diseases. HSP60 of KD children was significantly lower than those of children with tuberculosis (P< 0.01). The findings showed that HSP60, HSP70 might contribute to the pathogenesis of KD. Determination of HSP60 HSP70 in lymphocytes is of help in the diagnosis of KD.
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Dudani A K, Gupta R S. Immunological characterization of human homolog of the 65-KD mycobacterial antigen. Infect Immun, 1989, 57(9): 2786
Yokota S, Tsubaki K, Kuriyama Tet al. Presence in Kawasaki Disease of antibodies to mycobacterial heat-shock protein 65 and autoantibodies to epitopes of human heat-shock protein 65 cognate antigen. Clin Immunopathol, 1993, 67(2):163
Blake M J, Udelsman R, Feulner G Jet al. Stress-induced HSP70 express in adrenal cortex: an adrenocorticotropic hormone-sensitive, agedependent response. Proc Natl Acad Sci USA, 1991, 88:9873
Bohdan J, Solty S, Radhey Set al. Immunoelectron microscopic localization of 60KD HSP in mammalian cells. Exp Cell Res, 1996, 222(1): 16
Takeshita S, Kawase H, Yamamoto Met al. Increased expression of human 63-KD heat shock protein gene in Kawasaki Disease determined by quantitative reverse transcription-polymerase chain reaction. Paediatr Res, 1994, 35 (2):179
Jones D B, Coulson A F W, Duff G Wet al. Sequence homologies between HSP60 and autoantigen. Immunol Today, 1993, 14(3):115
Cohen I R, Young D B. Autoimmunity, microbial immunity and the immunological homunculus. Immunol Today, 1991, 12(4):105
Wallis R S, Amir-Tahmasseb M, Ellner J Jet al. Induction of interleukin-1 and tumor necrosis factor by mycobacterial proteins: The monocyte Western blot. Proc Natl Acad Sci USA, 1990, 87(9-10);3348
Rowley A H, Wolinsky S M, Relman DAet al. Search for highly conserved viral and bacterial nucleric acid sequences corresponding to an etiologic agent of Kawasaki Disease. Pediatr Res, 1994, 36(5):567
Kingston A E, Hicks C A, Colston M Jet al. A 71-KD hsp from mycobacterium tuberculosis has modulatory effects on experimental rat arthritis. Clin Exp Immunol, 1996, 103(1):77
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Weiwei, L., Peixuan, C. & Shaojun, C. HSP60, HSP70 in the pathogenesis of kawasaki disease: Implication and action. Current Medical Science 18, 145–148 (1998). https://doi.org/10.1007/BF02888523
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DOI: https://doi.org/10.1007/BF02888523