Abstract
Some antibiotics and synthetic inhibitors affect, in several ways, the life cycle ofNeurospora crassa (germination of conidia → myceliar growth → formation of conidia). Bikaverin, cyanein, scopathrioin and phenethyl alcohol retard the germination of conidia, without inhibiting it completely. 5-Fluorouracil, ramihyphin A and zygosporin A (cytoohalasin D) do not inhibit the germination. Bikaverin brings about a thickening of the hyphae of growing mycelium. Ramihyphin A, cyanein, scopathricin and zygosporin A stimulate the ramification of hyphae while 5-fluorouracil and phenethyl alcohol do not affect the myceliar morphology apart from their inhibitory effect on growth. Actinomycin D, 5-fluorouracil, cycloheximide, ramihyphin A and partially also sodium iodoacetate inhibit to a different degree the photoinduced formation of conidia. The inhibition by 5-fluorouracil is very conspicuous when the agent is present during the photoinduction but considerably weaker when it is applied 2 h after the photoinduction.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Baráth Z., Baráthová H., Betina V., Nemec P.: Ramihyphins, antifungal and morphogenic antibiotics fromFusarium sp. S-435.Folia Microbiol. 19, 507 (1974).
Baráthová H., Betina V., Baráth Z., Nemec P.: Morphogenic effects of ramihyphin A in filamentous fungi.Folia Microbiol. 20 97. (1975).
Betina V., Miceková D.: Morphogenetic activity of cytochalasins, cyanein and monorden inBotrytis cinerea.Allg. Mikrobiol. 13, 287 (1973).
Bhagwat A. S., Mahadevan P. R.: Conserved mRNA from the conidia ofNeurospora crassa.Mol. Gen. Genetics 109, 142 (1970).
Combépine G., Chervet J.: Preparation of isolated macroconidia ofNeurospora crassa.Experientia 25, 984 (1969).
Cornforth J. W., Ryback G., Robinson P. M., Park D.: Isolation and characterisation of fungal vacuolation factor (bikaverin).J. Chem. Soc. C 2786 (1971).
Galun E., Gressel J.: Morphogenesis inTrichoderma: Suppression of photoinduction by 5-fluorouracil.Science 151, 696 (1966).
Gressel J., Galun E.: Morphogenesis inTrichoderma: Photoinduction and RNA.Develop. Biol. 15, 575 (1967).
Hütter R., Keller-Schielein W., Nüsch J., Zähner H.: Stoffwechselprodukte von Mikroorganismen. 48. Mitteilung. Scopamycine.Arch. Mikrobiol. 51, 1 (1965).
Katz D., Goldstein D., Rosenberger R. F.: Model for branch initiation inAspergillus nidulans based on measurements of growth parameters.J. Bacteriol. 109, 1097 (1972).
Lingappa B. T., Prasad M., Lingappa Y.: Phenethyl alcohol and tryptophol: autoantibiotics produced by the fungusCandida albicans.Science 163, 192 (1969).
Mahadevan P. R., Tatum E. L.: Relationship of the major constituents of theN. crassa cell wall to wild-type and colonial morphology.J. Bacteriol. 90, 1073 (1965).
Nunn W. D., Tropp B. E.: Effects of phenethyl alcohol on phospholipid metabolism inEscherichia coli.J. Bacteriol. 109, 162 (1972).
Treick R. W., Konetzka W. A.: Physiological state ofEscherichia coli and the inhibition of deoxyribonucleic acid synthesis by phenethyl alcohol.J. Bacteriol. 88, 1580 (1964).
Turian G.: Morphogenesis inAscomycetes, p. 339 in G. C. Ainsworth and A. F. Sussman (Eds.):The Fungi, Vol. II, Academic Press, New York—London 1966.
Vogel H. J.: A convenient growth medium forNeurospora (medium N).Microbiol. Genet. Bull. 13, 42 (1956).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Betina, V., Janstová, D. & Spisiaková, J. Effects of antibiotics on the life cycle ofNeurospora crassa . Folia Microbiol 20, 340–345 (1975). https://doi.org/10.1007/BF02878116
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02878116