Abstract
The effect of twenty two spices on liver microsomal monooxygense activity was tested as measured by alteration of hexobarbital (HB) narcosis and strychnine mortality in mice. Oral administration of seven spices for 7 consecutive days caused a significant shortening of the duration of HB-induced sleeping time. The treatment of mice with a singlei.p. injection of 9 spices resulted in a significant prolongation of the sleeping time. White pepper, dill and fennel reduced the toxicity of strychine. These results strongly indicated that some spices might affect the activity of liver microsomal drug metabolizing enzyme (DME) function.
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Literature Cited
Conney, A.H.: Pharmacological implications of microsomal enzyme induction.Pharmacol. Rev. 19, 317(1967).
Shin, K.H. and Woo, W.S.: A survey of the response of medicinal plants on drug metabolism.Kor. J. Pharmacog. 11, 109(1980).
Wattenberg, L.W.: Studies of polycyclic hydrocarbon hydroxylases of the intestine possibly related to cancer.Cancer 28, 99 (1971).
Whang, E.H., Shin, K.H. and Woo, W.S.: Effect of wild vegetables on biotransformation of drug.Ann. Rep. Nat. Prod. Res. Inst. 20, 4(1981).
Jori, A., Bianchetti, A. and Prestini, P.E.: Effect of essential oils on drug metabolism.Biochem. Pharmacol. 18, 2081 (1969).
Shin K.H., Yun, H.S., Woo, W.S. and Lee, C.K.: Pharmacologically active principle ofPiper retrofractum.Kor. J. Pharmacog. 10, 69(1979).
Woo, W.S., Shin, K.H. and Kim, Y.S.: Hypnosis potentiating substance ofPiper nigrum.Ann. Rep. Nat. Prod. Res. Inst. 18, 12(1979).
Remmer, H. and Merker, H.J.: Effect of drugs on the formation of smooth endoplasmic reticulum and drug metabolizing enzymes.Ann. N.Y. Acad. Sci. 123, 79(1965).
Adamson, R.H. and Fouts, J.R.: Enzymatic metabolism of strychnine.J. Pharm. Exp. Ther. 127, 87(1959).
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Han, Y.B., Shin, K.H. & Woo, W.S. Effect of spices on hepatic microsomal enzyme function in mice. Arch. Pharm. Res. 7, 53–56 (1984). https://doi.org/10.1007/BF02856922
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DOI: https://doi.org/10.1007/BF02856922