Abstract
Objective: To study the relationship between HPV-associated cervical cancer and p53 codon 72 polymorphism in Sichuan Province.Methods: Three groups of women were studied: 30 women for normal control; 30 women with ovarian cancer; 50 women with cervical cancer. DNA from peripheral blood samples and from pathologic tissue sections was examined by PCR with allele-specific primers.Results: The proportions of individuals homozygous for the arginine allele, homozygous for the proline allele and heterozygous for the two alleles were 33.3%, 6.7% and 60% respectively among normal women; 40%, 6.7% and 53.3% in women with ovarian cancer respectively; 80%, 6% and 14% in women with cervical cancer respectively χ2 analysis showed significant differences in the proportions.Conclusion: In this population, individuals homozygous for the arginine variant of codon 72 of the p53 gene were at increased risk of cervical cancer.
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This study was supported by the China Scholarship Council (No. C9923).
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Mingrong, X., Yuedong, H., Xiaoyun, Y. et al. The preliminary study on the relationship between HPV-associated cervical cancer and p53 codon 72 polymorphism in Sichuan province. Chin. -Ger. J. Clin. Oncol. 2, 160–162 (2003). https://doi.org/10.1007/BF02842290
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DOI: https://doi.org/10.1007/BF02842290