Abstract
The working conditions were found for the determination of medicinal substances anesthesin (benzocaine,I), novocaine (II), novocainamide (procainamide,III), and sodium 4-aminosalicylate (IV) as their 4,6-dinitrobenzofuroxan derivatives by flow-injection analysis with spectrophotometric detection (λ 510 nm). The best conditions were attained using a mixture of ethanol (methanol) and a buffer solution of pH 6.68 (30: 70 vol %). The analytical range for the analytes was 0.08-5.0 μg/mL. The detection limits (3σ,n = 4) were 0.04 (I), 0.05 (II), 0.07 (III), and 0.03 (IV) μg/mL. Procedures for determining 4-aminobenzoic and 4-aminosalicylic acid derivatives in pharmaceuticals containing ephedrine, atropine, dimedrol, and inorganic salts and in biological fluids (protein hydrolyzate, blood plasma, and whole blood) were developed.
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Evgen’ev, M.I., Garmonov, S.Y. & Shakirova, L.S. Selective determination of 4-aminobenzoic and 4-aminosalicylic acid derivatives in mixtures by flow-injection analysis. J Anal Chem 55, 696–702 (2000). https://doi.org/10.1007/BF02828010
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DOI: https://doi.org/10.1007/BF02828010