Abstract
Hydrophobicity and profiles of outer membrane proteins ofShigella dysenteriae type 1 after treatment with subinhibitory concentrations (1/2 or 1/4 of the MIC) of aminoglycosides were studied. The antimicrobial activity of the antibiotics tested was 3.12 mg/L (amikacin, tobramycin) and 6.25 mg/L (gentamicin). The hydrophobicity of the cell surface ofS. dysenteriae type 1 was decreased after exposure to all aminoglycosides at a concentration of 1/2 of the MICs; 1/4 of the MICs of the antibiotics did not affect bacterial aggregation in the presence of ammonium sulfate. SDS-polyacrylamide gel electrophoresis showed that the profiles of outer membrane proteins of the strain treated with aminoglycosides at both subinhibitory concentrations were not changed as compared to the control.
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Hoštacká, A., Karelová, E. Hydrophobicity and outer membrane proteins ofShigella dysenteriae type 1 after treatment with subinhibitory concentrations of aminoglycosides. Folia Microbiol 42, 565–568 (1997). https://doi.org/10.1007/BF02815466
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DOI: https://doi.org/10.1007/BF02815466