Abstract
The trivalent state of chromium (Cr3+) is that encountered in biological milieus and is responsible for its nutritional activity. The principal route by which trivalent chromium enters the body is the digestive system. Chromium in foods is present both in the inorganic form and as organic complexes. Intestinal absorption of chromium is low (0.5–2%), and the mechanism has not yet been fully elucidated. Absorbed chromium circulates as free Cr3+, as Cr3+ bound to transferrin or other plasma proteins, or as complexes, such as glucose tolerance factor (GTF)-Cr. Circulating trivalent chromium can be taken up by tissues, and its distribution in the body depends on the species, age, and chemical form. It is excreted primarily in the urine by glomerular filtration or bound to a low-mol-wt organic transporter. Chromium metabolism is still imperfectly understood. The use of51Cr has nevertheless furnished valuable data concerning its transport and excretion.
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References
S. Wallach,J. Am. Coll. Nutr. 4, 107–120 (1985).
W. Mertz,Nutr. Rev. 81, 129–135 (1975).
M. Anderson, D. Riley, and J. Rotruck,Fed. Proc. 39, 787 (1980).
R. A. Anderson,Trace Elements in Human and Animal Nutrition, vol. 1, W. Mertz, ed., Academic, New York, 1987, pp. 225–244.
W. Mertz,Physiol. Rev. 49, 163–239 (1969).
B. E. Guthrie,Biological and Environmental Aspects of Chromium, S. Langard, ed., Elsevier Biomedical, Amsterdam, 1982, pp. 117–148.
R. A. Anderson and N. A. Bryden,J. Agric. Food Chem. 31, 308–311 (1983).
N. S. C. Chen, A. Tsai, and I. A. Dyer,J. Nutr. 103, 1182–1186 (1973).
R. J. Doisy, D. P. H. Streeten, J. M. Freiberg, and A. J. Schneider,Trace Elements in Human Health and Disease, vol. II, A. S. Prasad and D. Oberleas, eds., Academic, New York, 1976, pp. 79–104.
W. Mertz, E. E. Roginski, and R. C. Reba,Am. J. Physiol. 209, 489–494 (1965).
R. M. Donaldson and R. F. Barreras,J. Lab. Clin. Med. 68, 484–493 (1966).
W. Mertz and E. E. Roginski,Newer Trace Elements in Nutrition, W. Mertz and W. E. Cornatzer, eds., Dekker, New York, 1971, pp. 123–153.
H. J. Dowling, E. G. Offenbacher, and F. X. Pi-Sunyer,Fed. Proc. 45, 484 (1986).
H. J. Dowling, E. G. Offenbacher, and F. X. Pi-Sunyer,J. Nutr. 119, 1138–1145 (1989).
M. Urberg, M. Parent, D. Mill, and M. Zemel,Diabetes 35, 37a (1986).
M. N. Wang, Y. C. Li, K. Odalut, and B. J. Stoecker,Fed. Proc. 44, 751 (1985).
C. D. Seaborn and B. J. Stoecker,J. Nutr. 119, 1444–1451 (1989).
L. Solvell,Acta Med. Scand. 168 (suppl. 358), 71–104 (1960).
C. J. Hahn and G. W. Evans,Am. J. Physiol. 228, 1020–1023 (1975).
C. H. Hill,Trace Elements in Human Disease, A. S. Prasad, ed., Academic, New York, 1975, pp. 281–300.
L. L. Hopkins, Jr. and K. Schwarz,Biochim. Biophys. Acta 90, 484–491 (1964).
R. A. Anderson and A. S. Kozlovsky,Am. J. Clin. Nutr. 41, 1177–1183 (1985).
Y. Sayato, K. Nakamuro, S. Matsui and M. Ando,J. Pharm. Dyn. 3, 17–23 (1980).
A. Yamamoto, O. Wada, and T. Ono,J. Inorg. Biochem. 22, 91–102 (1984).
H. A. Schroeder, J. J. Balassa, and I. H. Tipton,J. Chronic. Dis. 15, 941–964. (1962).
H. A. Schroeder, A. P. Nason, and I. H. Tipton,J. Chronic. Dis. 23, 123–142 (1970).
J. M. Morgan,Metab. Clin. Exp. 21, 313–316 (1972).
D. J. Eatough, L. O. Hansen, S. E. Starr, M. S. Astin, S. B. Larsen, R. M. Izatt, and J. J. Christensen,Trace Element Metabolism in Man and Animals, vol. III, M. Kirchgessner, ed., Institut fur Ernahrungspysislogie, Freising-Weihenstephan, 1978, pp. 259–263.
W. J. Visek, I. B. Whitney, U. S. G. Kuhn, III, and C. L. Comar,Proc. Soc. Exp. Biol. Med. 84, 610–615 (1953).
J. Edel, E. Sabbioni, R. Pietra, B. Wallaeys, and L. Manzo,Trace Elements in Man and Animals, vol. 5, C. F. Mills, I. Bremner, and J. K. Chesters, eds., Commonwealth Agricultural Bureaux, Aberdeen, 1985, pp. 702–707.
L. Kraintz and R. V. Talmage,Proc. Soc. Exp. Biol. Med. 81, 490–492 (1952).
P. O. Berggren, and P. R. Flatt,Nutr. Rep. Int. 31, 213–218 (1985).
L. L. Hopkins, Jr.,Am. J. Physiol. 209, 731–735 (1965).
S. Wallach and R. L. Verch,J. Am. Coll. Nutr. 5, 291–298 (1986).
S. Wallach and R. L. Verch,Trace Elements in Medicine 6, 9–11 (1989).
R. K. Mathur and R. J. Doisy,Proc. Soc. Exp. Biol. Med. 139, 836–838 (1972).
I. Raz, J. H. Adler, and E. Havivi,Diabetologia 31, 329–333 (1988).
R. J. Doisy, D. P. H. Streeten, M. L. Souma, M. E. Kalafer, S. L. Rekant, and T. G. Dalakos,Newer Trace Element in Nutrition, W. Mertz and W. E. Cornatzer, eds., Dekker, New York, 1971, pp. 155–168.
M. Florkin and E. H. Stotz,Comprehensive Biochemistry, vol. 21, Elsevier, 1971, pp. 230–233.
R. A. Anderson, M. M. Polansky, N. A. Bryden, E. E. Roginski, K. Y. Patterson, C. Veillon, and W. H. Glinsmann,Am. J. Clin. Nutr. 36, 1184–1193 (1982).
R. A. Anderson, M. M. Polansky, N. A. Bryden, K. Y. Patterson, C. Veillon, and W. H. Glinsmann,J. Nutr. 113, 276–281 (1983).
D. L. Donaldson and O. M. Rennert,Ann. Clin. Lab. Science 11, 377–385 (1981).
D. L. Donaldson, C. C. Smith, and A. A. Yunice,Am. J. Physiol. 246, F870-F878 (1984).
G. Y. Wu and O. Wada,Jpn. J. Ind. Health 23, 505–512 (1981).
S. Wallach and R. L. Verch,J. Am. Coll. Nutr. 2, 163–172 (1983).
S. Wallach and R. L. Verch,J. Am. Coll. Nutr. 5, 299–304 (1986).
C. Onkelinx,Am. J. Physiol. 232, E478-E484 (1977).
R. Jain, R. L. Verch, S. Wallach, and R. A. Peabody,Am. J. Clin. Nutr. 34, 2199–2204 (1981).
T. H. Lim, T. Sargent III, and N. Kusubov,Am. J. Physiol. 244, R445-R454 (1983).
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Ducros, V. Chromium metabolism. Biol Trace Elem Res 32, 65–77 (1992). https://doi.org/10.1007/BF02784589
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DOI: https://doi.org/10.1007/BF02784589